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Comprehensive transcriptome analysis of uterine papillary serous carcinoma using next generation sequencer.

Research Project

Project/Area Number 24592499
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTohoku University

Principal Investigator

HANEDA Ken  東北大学, 大学病院, 助手 (10622433)

Co-Investigator(Kenkyū-buntansha) SUZUKI Fumihiko  東北大学, 大学院医学系研究科, 助教 (20400343)
SUZUKI Kichiya  東北大学, 東北メディカル・メガバンク機構, 准教授 (30422116)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords漿液性子宮体がん / マイクロRNA / 次世代シークエンサー / 漿液性子宮体癌
Outline of Final Research Achievements

Uterine papillary serous carcinoma (UPSC), unlike type I endometrial cancer, represents myometrial invasion and lymph node metastasis, even in the early stage of uterine cancer. It has been characterized by a high recurrence rate and a poor prognosis in gynecological malignant tumors. However, the occurrence and development mechanisms of UPSC are still unknown. Thus, in this study, we focused on the UPSC transcriptome. By using next-generation sequencing technology and DNA microarray technology, we attempt to analyze the specific transcriptome in tissues and serum to understand the molecular mechanisms and signaling pathways controlling the development. This study provides a perspective on the expression profile of UPSC, which will be a contribution in the molecular target therapy and a novel biomarker discovery in the future.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Decreased Expression of 14-3-3σ is Predictive of Poor Prognosis for Patients with Human Uterine Papillary Serous Carcinoma.2013

    • Author(s)
      Suzuki F, Nagase S, Suzuki K, Oba E, Hiroki E, Matsuda Y, Akahira J, Nishigori H, Sugiyama T, Otsuki T, Yoshinaga K, Takano T, Niikura H, Ito K, Sasano H, Yaegashi N.
    • Journal Title

      Tohoku J Exp Med

      Volume: 231 Pages: 193-199

    • NAID

      130004720755

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] DNA demethylation-dependent AR recruitment and GATA factors drive Rhox5 homeobox gene transcription in the epididymis.2012

    • Author(s)
      Bhardwaj A, Song HW, Beildeck M, Kerkhofs S, Castoro R, Shanker S, De Gendt K, Suzuki K, Claessens F, Issa JP, Orgebin-Crist MC, Wilkinson MF
    • Journal Title

      Mol Endocrinol

      Volume: 26 Pages: 538-549

    • Related Report
      2012 Research-status Report
    • Peer Reviewed

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Published: 2013-05-31   Modified: 2019-07-29  

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