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Genetic mutational profiling of endometrail cancer aiming at individualized treatment

Research Project

Project/Area Number 24592503
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Tsukuba

Principal Investigator

MINAGUCHI Takeo  筑波大学, 医学医療系, 講師 (40372396)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Hiroyuki  筑波大学, 医学医療系・産科婦人科学, 教授 (40158415)
OKI Akinori  筑波大学, 医学医療系・産科婦人科学, 教授 (60334067)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsPTEN / p53 / 子宮体癌 / 遺伝子変異 / 蛋白発現 / 予後因子 / 放射線治療 / p53 / 予後
Outline of Final Research Achievements

Protein exressions and genetic mutations of PTEN and p53 were analyzed and correlated with clinicopathological factors and prognosis in endometrial cancers. Negative PTEN expression was associated with endometrioid histology and absent lymphovascular invasion and was a favorable prognostic factor, while positive p53 was associated with non-endometrioid histology and advanced stage and was a poor prognostic factor. Postoperative radiotherapy improved survival only in p53 negative patients, and was a favorable prognostic factor for p53 negative patients. Accordingly, it is suggested that PTEN genetic aberration causes indolent biological property and p53 aberration causes rapid progression and low radiosensitivity, affecting endometrial cancer prognosis independently.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Loss of PTEN expression is an independent predictor of favourable survival in endometrial carcinomas.2013

    • Author(s)
      Akiyama-Abe A, Minaguchi T, Nakamura Y, Michikami H, Shikama A, Nakao S, Sakurai M, Ochi H, Onuki M, Matsumoto K, Satoh T, Oki A, Yoshikawa H
    • Journal Title

      British Journal of Cancer

      Volume: 109 Issue: 6 Pages: 1703-1710

    • DOI

      10.1038/bjc.2013.455

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] PTEN蛋白発現の欠失は子宮体癌の独立した予後良好因子である2012

    • Author(s)
      水口剛雄、安倍 梓、中村優子、田坂暢崇、中尾砂理、越智寛幸、小貫麻美子、岡田智志、松本光司、佐藤豊実、沖 明典、吉川裕之
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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