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Chemoprevention of endometrial cancer by metfomrin

Research Project

Project/Area Number 24592504
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionChiba University

Principal Investigator

MITSUHASHI Akira  千葉大学, 医学(系)研究科(研究院), 准教授 (40302541)

Co-Investigator(Kenkyū-buntansha) SHOZU Makio  千葉大学, 大学院医学研究院, 教授 (30226302)
NISHIKIMI Kyoko  千葉大学, 医学部附属病院, 助教 (00536302)
YAMAMOTO Noriko  千葉大学, 医学部附属病院, 医員 (30586722)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords子宮内膜癌 / インスリン抵抗性 / メトホルミン / 子宮体癌
Outline of Final Research Achievements

Therapeutic doses of metformin decreased the Ki-67 and topoisomerase II α labeling indices and inhibited the proliferative activity of endometrial cancer tissues. Preoperative use of metformin resulted in a significant decrease in the concentration of circulating factors, including insulin, glucose, insulin-like growth factor 1, and leptin. Moreover, metformin administration resulted in a significant decrease in the DNA synthesis-stimulating activity in patient sera.
The concentration of metformin in the tissues was <1/400 times lower than the minimum concentration required to inhibit cell growth in vitro. Metformin inhibits cancer cell growth indirectly through changes in humoral factors such as adipocytokines (secreted by adipocytes). Therefore, metformin might confer a protective effect against endometrial cancer in women with obesity and insulin resistance.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (16 results)

All 2015 2014 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (11 results)

  • [Journal Article] Metformin potentiates the anticancer effects of cisplatin under normoxic conditions in vitro2015

    • Author(s)
      TAKASHI UEHARA, AKIRA MITSUHASHI, NOBUHIDE TSURUOKA, MAKIO SHOZU1
    • Journal Title

      ONCOLOGY REPORTS

      Volume: 33 Issue: 2 Pages: 744-750

    • DOI

      10.3892/or.2014.3611

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 糖尿病治療薬メトホルミンが子宮体がんに奏効する可能性2015

    • Author(s)
      三橋暁
    • Journal Title

      産科と婦人科

      Volume: 82

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Effects of metformin on endometrial cancer cell growth in vivo: a preoperative prospective trial2014

    • Author(s)
      Akira Mitsuhashi, Takako Kiyokawa, Yasunori Sato, Makio Shozu
    • Journal Title

      Cancer

      Volume: 120 Issue: 19 Pages: 2986-2995

    • DOI

      10.1002/cncr.28853

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 子宮体がんの妊孕性温存療法2013

    • Author(s)
      三橋 暁
    • Journal Title

      臨床婦人科産科

      Volume: 67 Pages: 498-504

    • Related Report
      2013 Research-status Report
  • [Journal Article] 子宮体がんでの妊孕性温存療法の新たな展開2013

    • Author(s)
      三橋 暁
    • Journal Title

      産婦人科の実際

      Volume: 62 Pages: 1207-1213

    • Related Report
      2013 Research-status Report
  • [Presentation] メトホルミンはインスリン抵抗性改善による間接効果で子宮内膜癌の増殖を抑制する2015

    • Author(s)
      三橋 暁
    • Organizer
      第88回日本内分泌学会
    • Place of Presentation
      ホテルニューオータニ東京(東京都千代田区)
    • Year and Date
      2015-04-23 – 2015-04-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prospective evaluation of glucose tolerance and insulin resistance among patients with endometrial cancer and atypical endometrial hyperplasia2014

    • Author(s)
      Mitsuhashi, A. Hanawa, S. Yamamoto, N. Uehara, T. Nishikimi, K. Tate, S. Usui, H. Shozu, M.
    • Organizer
      ESMO2014
    • Place of Presentation
      バルセロナ(スペイン)
    • Year and Date
      2014-09-26 – 2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] A phase II study of medroxyprogesterone acetate plus metformin as fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer.2014

    • Author(s)
      Mitsuhashi, A. Usui, H. Satoh, Y. Kiyokawa, T. Shozu, M.
    • Organizer
      ASCO2014
    • Place of Presentation
      CHIKAGO(USA)
    • Year and Date
      2014-05-30 – 2014-06-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prospective evaluation of abnormal glucose metabolism and insulin resistance among patients with endometrial cancer and atypical endometrial hyperplasia2014

    • Author(s)
      Akira Mitsuhashi, Shinsuke Hanawa, Noriko Yamamoto, Takashi Uehara, Kyoko Nishikimi, Shinichi Tate, Hirokazu Usui, Makio Shozu
    • Organizer
      第66回日本産科婦人科学会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2014-04-18 – 2014-04-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] メトホルミンは間接的に子宮内膜癌患者の増殖を抑制する2013

    • Author(s)
      三橋 暁
    • Organizer
      第65回日本産科婦人科学会 学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] メトホルミンは間接的に子宮内膜癌患者の増殖を抑制する2013

    • Author(s)
      三橋 暁
    • Organizer
      第54回 日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] メトホルミンは間接的に子宮内膜癌患者の増殖を抑制する2013

    • Author(s)
      三橋 暁
    • Organizer
      第14回ホルモンと癌研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] メトホルミンは単独および抗がん薬との併用で子宮体癌細胞の増殖を抑制する2013

    • Author(s)
      植原 貴史、三橋 暁
    • Organizer
      第65回日本産科婦人科学会 学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] Therapeutic doses of metformin suppresses cell proliferation of endometrial cancer in vivo.2012

    • Author(s)
      A Mitsuhashi et al.
    • Organizer
      14th IGCS
    • Place of Presentation
      Vancouver ,Canada
    • Related Report
      2012 Research-status Report
  • [Presentation] Metformin prevents recurrence of endometrial cancer or atypical endometrial hyperplasia after progestin therapy and improves insulin resistance for fertility-sparing treatment in young women.2012

    • Author(s)
      A Mitsuhashi et al.
    • Organizer
      15th ICHSHC
    • Place of Presentation
      Kanazawa, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] 子宮体癌・子宮内膜異型増殖症に対するメドロキシプロゲステロン+メトホルミン併用妊孕性温存療法の前方視的試験.2012

    • Author(s)
      三橋 暁
    • Organizer
      第52回日本婦人科腫瘍学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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