Investigation of a candidate protein associated with chemo-resistance of endometrial carcinomas
| Project/Area Number |
24592516
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka University |
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Principal Investigator |
UEDA Yutaka 大阪大学, 医学(系)研究科(研究院), 助教 (10346215)
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| Co-Investigator(Kenkyū-buntansha) |
ENOMOTO Takayuki 大阪大学, 医学系研究科, 招へい教員 (90283754)
FUJITA Masami 大阪大学, 医学系研究科, 招へい准教授 (60303963)
YOSHINO Kiyoshi 大阪大学, 医学系研究科, 准教授 (90362730)
KIMURA Toshihiro 大阪大学, 医学系研究科, 招へい教員 (90584524)
KOBAYASHI Eiji 大阪大学, 医学系研究科, 助教 (50614773)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 婦人科腫瘍 / 子宮体癌 / 化学療法 / 抵抗性 / 蛋白質発現 / 抗癌剤抵抗性 / iTRAQ法 / 蛋白質 |
|---|
| Outline of Final Research Achievements |
Enhanced expression of Annexin A4 (Anx A4) increases chemoresistance to plutinum through increased extracellular efflux of the drug. Exposure to platinum drugs induced relocation of Anx A4 from the cytoplasm to the cellular membrane, where it became colocalized with ATP7A, a copper transporter also well known as a mechanism of platinum efflux. Calcium-binding site in the annexin repeat induces chemoresistance to the platinum drug by elevating the intracellular chloride.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Annexin A4-conferred platinum resistance is mediated by the copper transporter ATP7A2014
Author(s)
Matsuzaki S, Enomoto T, Serada S, Yoshino K, Nagamori S, Morimoto A, Yokoyama T, Kim A, Kimura T, Ueda Y, Fujita M, Fujimoto M, Kanai Y, Kimura T, Naka T
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Journal Title
Int J Cancer
Volume: 134
Issue: 8
Pages: 1796-1809
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Annexin A4 induces platinum resistance in a chloride-and calcium-dependent manner2014
Author(s)
Morimoto, A. Serada, S. Enomoto, T. Kim, A. Matsuzaki, S. Takahashi, T. Ueda, Y. Yoshino, K. Fujita, M. Fujimoto, M. Kimura, T. Naka, T.
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Journal Title
Oncotarget
Volume: 5(17)
Pages: 7776-87
Related Report
Peer Reviewed
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[Journal Article] Plasma nlembrane proteonlics identifies bone marrow stromal antigen 2 as a potential therapeutic target in endometrial cancer2013
Author(s)
Yokoyama T, Enomoto T, Serada S, Morimoto A, Matsuzaki S, Ueda Y, Yoshino K, Fujita M, Kyo S, Iwahori K, Fujimoto M, Kimura T, Naka T
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Journal Title
Int J Cancer
Volume: 132(2)
Issue: 2
Pages: 472-84
DOI
Related Report
Peer Reviewed
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[Presentation] Annexin A4-conferred platinum resistance is mediated by the copper transporter ATP7A2013
Author(s)
Matsuzaki, S. Morimoto, A. Serada, S. Yokoyama, T. Kimura, T. Kobayashi, E. Ueda, Y. Yoshino, K. Fujita, M. Enomoto, T. Naka, T. Kimura, T.
Organizer
The 104th Annual Meeting American Association for Cancer Research
Place of Presentation
Washington DC, U.S.A
Related Report
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