Nobel therapeutic strategy against human cancer by targeting RCAS1
| Project/Area Number |
24592519
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
SONODA Kenzo 九州大学, 医学(系)研究科(研究院), 准教授 (30294929)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | RCAS1 / リンパ球アポトーシス / 腫瘍間質組織 / 血管新生 / ectodomain shedding / 悪性腫瘍 / 治療標的分子 / RNA干渉 |
|---|
| Outline of Final Research Achievements |
RCAS1 can induce apoptosis in immune cells including peripheral lymphocytes and natural killer cells after converted to a secreted type by ectodomain shedding. Because RCAS1 not only helps tumor cells to evade immune surveillance but also induces cancer stromal tissue remodeling, RCAS1 is believed to exaggerate aggressive characteristics of human malignancies. RCAS1 expression correlates with several clinicopathological variables including tumor size, stage, invasion depth, and lymph node metastasis and is a negative predictor of overall survival in 15 different kinds of cancer. Novel therapeutic strategies against cancer are now under development by targeting an intriguing biomarker RCAS1.
|
Report
(4 results)
Research Products
(18 results)
-
[Journal Article] Uterine myxoid leiomyosarcoma with tumor embolism extending into the right atrium2015
Author(s)
Hiromi Imai, Hiroshi Yagi, Kaoru Okugawa, Hironori Kenjo, Tatsuhiro Ohgami, Yoshiaki Kawano, Eisuke Kaneki, Akimasa Ichinoe, Kazuo Asanoma, Hideaki Yahata, Kenzo Sonoda, Hiroaki Kobayashi, Tsunehisa Kaku, Kiyoko Kato
-
Journal Title
Case Reports in Obstetrics and Gynecology
Volume: 2015
Pages: 316262-316262
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
