development by overcoming resistance to anticancer drugs against ovarian clear cell adenocarcinoma
| Project/Area Number |
24592526
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kinki University (2014)
Nara Medical University (2012-2013) |
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Principal Investigator |
KANAYAMA Seiji 近畿大学, 医学部附属病院, 講師 (10423914)
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| Co-Investigator(Kenkyū-buntansha) |
SHIGETOMI Hiroshi 奈良県立医科大学, 医学部, 助教 (20433336)
HARUTA Shouji 奈良県立医科大学, 医学部, 助教 (30448766)
KOBAYASHI Hiroshi 奈良県立医科大学, 医学部, 教授 (40178330)
吉澤 順子 奈良県立医科大学, 医学部, 助教 (80526723)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 卵巣明細胞腺癌 / 抗がん剤耐性 / HNF1-beta / 細胞周期 / ｃｈｋ１ / 抗癌剤耐性 / HNF-1beta / 抗癌剤耐性機序解明 / 婦人科癌 |
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| Outline of Final Research Achievements |
As the gene which specifically emerged for an ovarian light cell adenocarcinoma, I identified HNF1-beta. Furthermore, after examining an association between HNF1-beta and DNA damage check mechanism, what the chk1 protein which was a main control factor of the checkpoint mechanism phosphorylated continuously was confirmed with the HNF1-beta-positive cell. Furthermore, participation of the claspin protein became clear in autophosphorylation of chk1. HNF1-beta broke down claspin by some kind of mechanism, and, for the ovarian light cell adenocarcinoma, it restrained it, and it guided the activation that chk1 was superabundant through expression maintenance, and an apoptosis instruction with the action-related bleomycin was inhibited for G2/M period by the examination of conventional us, and it was confirmed to show anticancer agent resistance
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Report
(4 results)
Research Products
(13 results)
