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development by overcoming resistance to anticancer drugs against ovarian clear cell adenocarcinoma

Research Project

Project/Area Number 24592526
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKinki University (2014)
Nara Medical University (2012-2013)

Principal Investigator

KANAYAMA Seiji  近畿大学, 医学部附属病院, 講師 (10423914)

Co-Investigator(Kenkyū-buntansha) SHIGETOMI Hiroshi  奈良県立医科大学, 医学部, 助教 (20433336)
HARUTA Shouji  奈良県立医科大学, 医学部, 助教 (30448766)
KOBAYASHI Hiroshi  奈良県立医科大学, 医学部, 教授 (40178330)
吉澤 順子  奈良県立医科大学, 医学部, 助教 (80526723)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords卵巣明細胞腺癌 / 抗がん剤耐性 / HNF1-beta / 細胞周期 / chk1 / 抗癌剤耐性 / HNF-1beta / 抗癌剤耐性機序解明 / 婦人科癌
Outline of Final Research Achievements

As the gene which specifically emerged for an ovarian light cell adenocarcinoma, I identified HNF1-beta. Furthermore, after examining an association between HNF1-beta and DNA damage check mechanism, what the chk1 protein which was a main control factor of the checkpoint mechanism phosphorylated continuously was confirmed with the HNF1-beta-positive cell. Furthermore, participation of the claspin protein became clear in autophosphorylation of chk1. HNF1-beta broke down claspin by some kind of mechanism, and, for the ovarian light cell adenocarcinoma, it restrained it, and it guided the activation that chk1 was superabundant through expression maintenance, and an apoptosis instruction with the action-related bleomycin was inhibited for G2/M period by the examination of conventional us, and it was confirmed to show anticancer agent resistance

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2014 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (6 results)

  • [Journal Article] Inhibition of Cell Death and Induction of G2 Arrest Accumulation in Human Ovarian Clear Cells by HNF-1β Transcription Factor: Chemosensitivity Is Regulated by Checkpoint Kinase CHK1.2014

    • Author(s)
      Shigetomi H, Sudo T, Shimada K, Uekuri C, Tsuji Y, Kanayama S, Naruse K, Yamada Y, Konishi N, Kobayashi H.
    • Journal Title

      Int J Gynecol Cancer

      Volume: - Issue: 5 Pages: 838-43

    • DOI

      10.1097/igc.0000000000000136

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms linking endometriosis under oxidative stress with ovarian tumorigenesis and therapeutic modalities.2012

    • Author(s)
      Shigetomi H, Tsunemi T, Haruta S, Kajihara H, Yoshizawa Y, Tanase Y, Furukawa N, Yoshida S, Sado T, Kobayashi H.
    • Journal Title

      Cancer Invest.

      Volume: 30(6) Pages: 473-80

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A potential link of oxidative stress and cell cycle regulation for development of endometriosis.2012

    • Author(s)
      Shigetomi H, Higashiura Y, Kajihara K, Kobayashi H
    • Journal Title

      Gynecol Endocrinol

      Volume: 28(11) Pages: 897-902

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] .The dichotomy in the histogenesis of endometriosis-associated ovarian cancer: clear cell-type versus endometrioid-type adenocarcinoma2012

    • Author(s)
      Kajihara H, Yamada Y, Shigetomi H, Higashiura Y, Kobayashi H
    • Journal Title

      Int J Gynecol Pathol.

      Volume: 31(4) Pages: 304-12

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Targeted molecular therapies for ovarian cancer: An update and future perspectives(Review)2012

    • Author(s)
      Shigetomi H, Higashiura Y, Kajihara K, Kobayashi H.
    • Journal Title

      Oncology Reports

      Volume: 28 Pages: 395-408

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Case of Early-Stage Ovarian Carcinoid Tumor Metastasized to the Liver2012

    • Author(s)
      Seiji Kanayama, Yoshihiko Yamada, Yasuhito Tanase, Shoji Haruta, Akira Nagai, Ryuji Kawaguchi, Shozo Yoshida, Naoto Furukawa, Hidekazu Oi, and Hiroshi Kobayashi
    • Journal Title

      Case Reports in Obstetrics and Gynecology

      Volume: 2012 Pages: 1-5

    • DOI

      10.1155/2012/961087

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The entry of fetal and amniotic fluid components into the uterine vessel circulation leads to sterile inflammatory processes during parturition.2012

    • Author(s)
      Kobayashi H.
    • Journal Title

      Front Immunol.2012;3:321

      Volume: 3 Pages: 1-6

    • DOI

      10.3389/fimmu.2012.00321

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 卵巣内膜症性嚢胞の鉄濃度測定による悪性化診断の有用性2014

    • Author(s)
      重富洋志、金山清二、川口龍二、大井豪一、小林 浩
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] チョコレート嚢胞の癌化の早期発見方法2014

    • Author(s)
      吉元千陽、重富洋志、森岡 佐知子、伊東史学、棚瀬康仁、春田祥治、金山清二、吉田昭三、古川直人、大井豪一、小林 浩
    • Organizer
      婦人科バイオマーカー研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] チョコレート嚢胞の癌化機序の解明と早期発見方法の確立2014

    • Author(s)
      吉元千陽、重富洋志、棚瀬康仁、吉田昭三、大井豪一、小林 浩
    • Organizer
      生殖医学フォーラム
    • Place of Presentation
      山口
    • Year and Date
      2014-05-09 – 2014-05-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 卵巣明細胞腺癌における転写因子HNF-1betaのDNA損傷チェックポイント機構の制御2012

    • Author(s)
      重富洋志, 須藤 保, 吉澤順子, 棚瀬康仁, 春田祥治,金山清二, 永井 景, 川口龍二,吉田昭三,古川直人, 大井豪一,小林 浩
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] HNF-1betaを過剰発現している卵巣明細胞腺癌においてchk 1阻害剤の併用は抗癌剤の感受性を高める2012

    • Author(s)
      重富洋志, 須藤 保、吉澤順子, 金山清二, 川口龍二,山田嘉彦、小林 浩
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 明細胞腺癌における転写因子HNF-1betaが制御するDNA損傷チェックポイント機構の解明

    • Author(s)
      重富洋志
    • Organizer
      第12回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      奈良県東大寺文化センター
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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