| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We established the humanized HMMC-1 antibody which recognizes gynecologic cancers and demonstrates specific anti-tumor activity towards endometrial cancer. In vitro, the antibody demonstrated anti-tumor activity towards endometrial cancer cells with differing lymph node metastasis potential and demonstrated even greater cell proliferation inhibitory effects towards the cell line with greater metastatic potential. Cell cycle analysis demonstrated that this difference in proliferation inhibition was not due to differences in proliferation or cell cycle. In addition, we elucidated the carbohydrate antigen recognized by the HMMC-1 antibody. Using mass spectrometry, we showed that the HMMC-1 antibody recognizes CD 166 and CD 49. Our research thus delineates the future possibility of clinical treatments based on HMMC-1 antibody administration as molecular target therapy towards endometrial cancer cases that demonstrate elevated CD 166 expression levels.
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