Immunosuppressive roles of HNF-1beta in ovarian clear cell carcinoma (OCCC)
Project/Area Number |
24592532
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Keio University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KAWAKAMI Yutaka 慶應義塾大学, 医学部, 教授 (50161287)
IWATA Takasi 慶應義塾大学, 医学部, 講師 (30296652)
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Co-Investigator(Renkei-kenkyūsha) |
AOKI Daisuke 慶應義塾大学, 医学部, 教授 (30167788)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 卵巣明細胞腺癌 / HNF-1beta / がん微小環境 / がん免疫抑制 / 癌 / がん免疫 / 卵巣癌 / 癌微小環境 |
Outline of Final Research Achievements |
Hepatocyte nuclear factor-1beta (HNF-1beta) is a transcription factor and is overexpressed in ovarian clear cell carcinoma (OCCC). Here, we investigated immunosuppressive roles of HNF-1beta in OCCC. IL-6 production and activation of NF-kB and STAT3 was associated with HNF-1beta accumulation in OCCC cell lines. Culture supernatants (CS) from HNF-1beta accumulated OCCC have activities to impair dendritic cells (DCs) maturation. These immunosuppressive CS activity was reduced by knocking down HNF-1beta, partly owing to down-regulation of IL-6. Murine splenic, lymphnode and tumor-infiltrating DCs obtained from nude mice implanted with HNF-1beta knocking down OCCC cells restored activity to activate T cell than did DCs from control OCCC cells. These results indicate that HNF-1beta in OCCC may be involved in the immunosuppression mediated by impaired DC, and is not only useful as the tumor marker but also attractive targets for restoring immunocompetence in patients with OCCC.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Prognostic significance of interleukin-8 and CD163-positive cell-infiltration in tumor tissues in patients with oral squamous cell carcinoma2014
Author(s)
Fujita Y, Okamoto M, Goda H, Tano T, Nakashiro K, Sugita A, Fujita T, Koido S, Homma S, Kawakami Y, Hamakawa H.
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Journal Title
PLoS ONE
Volume: 9
Issue: 12
Pages: e110378-e110378
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Immunochemoradiotherapy for patients with oral squamous cell carcinoma: augmentation of OK-432-induced helper T cell 1 response by 5-FU and X-ray irradiation2013
Author(s)
Tano T, Okamoto M, Kan S, Bando T, Goda H, Nakashiro K, Shimodaira S, Koido S, Homma S, Fujita T, Sato M, Yamashita N, Hamakawa H, Kawakami Y.
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Journal Title
Neoplasia
Volume: 15
Pages: 805-14
Related Report
Peer Reviewed
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[Journal Article] Prognostic impact of expression of Bcl-2 and Bax genes in circulating immune cells derived from patients with head and neck carcinoma2013
Author(s)
Tano T, Okamoto M, Kan S, Nakashiro K, Shimodaira S, Koido S, Homma S, Sato M, Fujita T, Kawakami Y, Hamakawa H.
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Journal Title
Neoplasia
Volume: 15
Pages: 305-14
Related Report
Peer Reviewed
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[Journal Article] Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasis via CCR4/CCL22 in head and neck squamous cell carcinoma2013
Author(s)
Tsujikawa T, Yaguchi T, Ohmura G, Ohta S, Kobayashi A, Kawamura N, Fujita T, Nakano H, Shimada T, Takahashi T, Nakao R, Yanagisawa A, Hisa Y, Kawakami Y
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Journal Title
Int J Cancer
Volume: 132(12)
Issue: 12
Pages: 2755-2766
DOI
Related Report
Peer Reviewed
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[Journal Article] Cancer-testis antigen BORIS is a novel prognostic marker for patients with esophageal cancer.2012
Author(s)
Okabayashi K, Fujita T, Miyazaki J, Okada T, Iwata T, Hirao N, Noji S, Tsukamoto N, Goshima N, Hasegawa H, Takeuchi H, Ueda M, Kitagawa Y, Kawakami Y.
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Journal Title
Cancer Sci
Volume: 103(9)
Issue: 9
Pages: 1617-24
DOI
Related Report
Peer Reviewed
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[Presentation] Cancer-induced differential immune-status among patients and it's modification for effective cancer treatment.2014
Author(s)
Kawakami Y, Popivanova B, Nagumo H, Muramatsu R, Shinobu Noji, Xu M, Fujita T, Okamoto M, Sakurai T, Sugiyama J, Hayakawa T, Satomi R, Nishio H, Yaguchi T.
Organizer
Cold Spring Harbor Asia, Frontiers of Immunology in Health and Diseases
Place of Presentation
Suzhou, China
Year and Date
2014-09-04
Related Report
Invited
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