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Fibrates protect against vascular endothelial dysfunction induced by paclitaxel and carboplatin chemotherapy for cancer patients: a pilot study.

Research Project

Project/Area Number 24592535
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionOsaka Medical College

Principal Investigator

TANABE Akiko  大阪医科大学, 医学部, 非常勤講師 (70454543)

Co-Investigator(Kenkyū-buntansha) HAYASHI Masami  大阪医科大学, 医学部, 講師 (00551748)
TANAKA Yoshimichi  大阪医科大学, 医学部, 助教 (10625502)
KANEMURA Masanori  大阪医科大学, 医学部, 講師 (40298782)
YAMASHITA Yoshiki  大阪医科大学, 医学部, 非常勤講師 (50268207)
TERAI Yoshito  大阪医科大学, 医学部, 准教授 (90278531)
OHMICHI Masahide  大阪医科大学, 医学部, 教授 (10283764)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords婦人科悪性腫瘍 / 抗がん剤 / 血管内皮障害 / フィブラート / 一酸化窒素 / TC療法 / 動脈硬化 / 血管内皮機能 / 抗癌剤
Outline of Final Research Achievements

This study enrolled 45 gynecological cancer patients who underwent surgical treatment followed by TC-chemotherapy. The elevated triglyceride (TG) group included patients who exhibited hypertriglyceridemia during TCchem, and the stable TG group included patients with a normal TG level. Fibrate group exhibiting hypertriglyceridemia during TCchem were administered bezafibrate. Endothelial dysfunction was evaluated by FMD measured before and immediately after the final TCchem. HUVECs were used to elucidate the biological mechanisms.
RESULTS:The administration of TCchem induced hypertriglyceridemia in 66 percent of the participant. The decrease in %FMD induced by TCchem improved following treatment with bezafibrate. An in vitro examination demonstrated TCchem attenuated nitric oxide production and PPARα activity in HUVECs, which was partially improved by bezafibrate.
CONCLUSION:Bezafibrate prevents endothelial dysfunction induced by TCchem via TG-dependent and TG-independent mechanisms.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2015 2014 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results)

  • [Journal Article] Fibrates protect against vascular endothelial dysfunction induced by paclitaxel and carboplatin chemotherapy for cancer patients: a pilot study.2015

    • Author(s)
      Watanabe A, Tanabe A, Maruoka R, Nakamura K, Hatta K, Ono YJ, Terai Y, Ohmichi M.
    • Journal Title

      Int J Clin Oncol

      Volume: 0 Issue: 4 Pages: 0-0

    • DOI

      10.1007/s10147-014-0779-y

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 婦人科悪性腫瘍に対するTC療法が及ぼす動脈硬化への影響とその予防について2014

    • Author(s)
      渡辺綾子 田辺晃子 中井香奈 永易洋子 丸岡理紗 高井雅聡 中村起代子 関島龍治 大道正英
    • Organizer
      第66回 日本産科婦人科学会
    • Place of Presentation
      東京都 東京国際フォーラム
    • Year and Date
      2014-04-18 – 2014-04-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 婦人科悪性腫瘍に対する抗癌剤治療が動脈硬化へ及ぼす影響とフィブラートの予防効果について2013

    • Author(s)
      渡辺綾子、田辺晃子、丸岡寛、斉藤奈津穂、澤田雅美、丸岡理紗、中井香奈、中村起代子、中村路彦、寺井義人、大道正英
    • Organizer
      第65回日本産婦人科学会学術集会
    • Place of Presentation
      北海道 ロイトン札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] The protective effect of fibrate against endothelial dysfunction induced by platinum-based chemotherapy in gynecological cancer patients2013

    • Author(s)
      Ayako Watanabe, Akiko Tanabe, Risa Maruoka, Kiyoko Nakamura, Masaaki Takai, Yoshito Terai, Masahide Ohmichi
    • Organizer
      The 5th scientific meeting of the asia pacific menopause federation
    • Place of Presentation
      東京 京王プラザホテル
    • Related Report
      2013 Research-status Report
  • [Presentation] 婦人科悪性腫瘍に対する抗癌剤治療が動脈硬化へ及ぼす影響とフィブラートの予防効果について2012

    • Author(s)
      渡辺綾子
    • Organizer
      第27回日本女性医学学会
    • Place of Presentation
      山形国際ホテル(山形県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 婦人科悪性腫瘍手術及び術後化学療法の動脈硬化に及ぼす影響についての検討2012

    • Author(s)
      渡辺綾子
    • Organizer
      第64回日本産科婦人科学会学術集会
    • Place of Presentation
      神戸国際展示場(兵庫県)
    • Related Report
      2012 Research-status Report
  • [Presentation] The Protective Effect of Fibrate aginst Endothelial Dysfunction Induced by Platinum-based Chemotherapy in Gynecological Cancer Patients2012

    • Author(s)
      渡辺綾子
    • Organizer
      68th Annual Meeting of American Society for Reproductive Medicine
    • Place of Presentation
      SanDiego convention center (San Diego,USA)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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