An elucidation of pathological condition and development new treatment strategy for eosinophilic otitis media using animal model.
| Project/Area Number |
24592537
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hirosaki University |
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Principal Investigator |
MATSUBARA Atsushi 弘前大学, 医学(系)研究科(研究院), 教授 (10260407)
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| Co-Investigator(Kenkyū-buntansha) |
NAMBA Atsushi 弘前大学, 医学部附属病院, 講師 (50361027)
SASAKI Akira 弘前大学, 医学部附属病院, 講師 (20451479)
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| Research Collaborator |
KUDO Naomi 弘前大学, 大学院医学研究科
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 好酸球性中耳炎 / 動物モデル / コルチ器 / 末梢前庭器 / 難聴 |
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| Outline of Final Research Achievements |
We investigated the pathological condition of eosinophilic otitis media (EOM) using animal model which we recently constructed. We constructed the animal model of EOM by intraperitoneal injection of ovalbumine (OVA) and subsequently intratympanic injection of OVA was performed for 7 days, 14 days, and 28 days. Infiltrating cells and the inner ear damage were examined by histological study. In the inner ear, a few eosinophils were seen in the inner ear and morphology was cochlea are well observed. As the periods of intratympanic injection of OVA to the middle ear became longer, the marked eosinophil infiltration in the perilymphtic space was observed. Moreover severe morphological damage of the organ of Corti was observed in the 28-day antigen stimulation side. These results indicated that eosinophilic inflammation occurred in the inner ear and caused profound hearing loss.
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Report
(4 results)
Research Products
(12 results)
