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Secretory mechanism of the submucosal gands in the eustachian tube and its regulation

Research Project

Project/Area Number 24592539
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionNihon University (2014)
Tohoku University (2012-2013)

Principal Investigator

OSHIMA Takeshi  日本大学, 医学部, 教授 (40241608)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords耳管腺 / 耳管機能 / 耳管開放症 / 分泌低下 / 耳管機能検査
Outline of Final Research Achievements

The secretory mechanism in the middle ear and tuba mucosa has crucial roles in strategies of the treatment and prevention of otitis media. In the present study, submucosal tubal glands could be identified. Primary culture could reveal the expression of acquaporin in the gland cells, suggesting of the significance of the secretion mechanism of the gland. In 301 ears suffering from patulous eustachian tube, the tubal function test was performed. Three types of the impedance wave forms could be revealed as the positive finding indicative of patulous eustachian tube.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (7 results) (of which Invited: 3 results)

  • [Journal Article] Preservation of cochlear function in Fabp3 (H-Fabp) knockout mice.2014

    • Author(s)
      Suzuki J, Oshima T, Yoshida N, Kimura R, Takata Y, Owada Y, Kobayashi T, Katori Y, Osumi N.
    • Journal Title

      Neurosci Res.

      Volume: 81-82 Pages: 64-68

    • DOI

      10.1016/j.neures.2014.02.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Change in endocochlear potential during experimental insertion of a simulated cochlear implant electrode in the guinea pig.2014

    • Author(s)
      Oshima H, Ikeda R, Nomura K, Yamazaki M, Hidaka H, Katori Y, Oshima T, Kawase T, Kobayashi T
    • Journal Title

      Otology and Neurotology

      Volume: 35 Issue: 2 Pages: 234-240

    • DOI

      10.1097/mao.0b013e3182a36018

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Closure technique for labyrinthine fistula by “underwater” endoscopic ear surgery2014

    • Author(s)
      Yamauchi D, Yamazaki M, Ohta J, Kadowaki S, Nomura K, Hidaka H, Oshima T, Kawase T, Katori Y
    • Journal Title

      Laryngoscope

      Volume: 124 Issue: 11 Pages: 2616-2618

    • DOI

      10.1002/lary.24785

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 耳管開放症診断における音響耳管法の問題点2013

    • Author(s)
      菊地俊晶、小林俊光、大島猛史、高田生織、大島英敏、池田怜吉、川瀬哲明
    • Journal Title

      Otology Japan

      Volume: 23 Pages: 193-197

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 耳管通気2013

    • Author(s)
      大島猛史
    • Journal Title

      耳鼻咽喉科・頭頸部外科

      Volume: 85 Pages: 254-257

    • Related Report
      2013 Research-status Report
  • [Journal Article] Risk factors for deterioration of bone conduction hearing in cases of labyrinthine fistula caused by middle ear cholesteatoma2012

    • Author(s)
      Ikeda R, Kobayashi T, Kawase T, Oshima T, Sato T
    • Journal Title

      Ann Otol Rhhinol Laryngol

      Volume: 121 Pages: 162-167

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 弛緩部型中耳真珠腫における開放耳管の合併率2014

    • Author(s)
      大島英敏、小林俊光、池田怜吉、菊地俊晶、大島猛史、香取幸夫
    • Organizer
      第24回日本耳科学会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2014-10-16 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 外耳道後壁削除型・乳突開放型鼓室形成術2014

    • Author(s)
      大島猛史
    • Organizer
      第24回日本耳科学会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2014-10-16 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 耳管開放症患者のBMIの検討2014

    • Author(s)
      菊地俊晶、高田生織、大島英敏、大島猛史、山内大輔、小林俊光、香取幸夫
    • Organizer
      第24回日本耳科学会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2014-10-16 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 弛緩部型中耳真珠腫における開放耳管の合併率弛緩部型中耳真珠腫における開放耳管の合併率2014

    • Author(s)
      大島英敏、小林俊光、池田怜吉、菊地俊晶、大島猛史、香取幸夫
    • Organizer
      第62回日耳鼻東北連合学会
    • Place of Presentation
      盛岡グランドホテル(岩手県盛岡市)
    • Year and Date
      2014-07-19 – 2014-07-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Eustachian tube plugging by Kobayashi’s PET plug2012

    • Author(s)
      Oshima T, Kikuchi T, Ikeda R, Oshima H, Kobayashi T
    • Organizer
      9th International Conference on Cholesteatoma and Ear Surgery
    • Place of Presentation
      Nagasaki
    • Related Report
      2012 Research-status Report
  • [Presentation] 耳管開放症2012

    • Author(s)
      大島猛史
    • Organizer
      第74回日本耳鼻咽喉科臨床学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 耳管疾患における内視鏡の応用2012

    • Author(s)
      大島猛史
    • Organizer
      第22回日本耳科学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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