Effects of ceramide and sphingolipids on cochlear injury
| Project/Area Number |
24592541
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Tabuchi Keiji 筑波大学, 医学医療系, 講師 (80361335)
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| Co-Investigator(Kenkyū-buntansha) |
原 晃 筑波大学, 医学医療系, 教授 (10156474)
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| Project Period (FY) |
2012-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 内耳 / 蝸牛 / シスプラチン / 有毛細胞 / 耳毒性 |
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| Outline of Final Research Achievements |
Ceramide and sphingosine increased cochlear injury induced by cisplatin. Ceramide and sphingosine themselves induced cochlear injury without cisplatin at high doses.On the other hand, ceramide-1-phosphate (C1P) decreased cochlear injury induced by cisplatin. Inhibition of ceramide kinase which converted ceramide to C1P significantly worsened cochlear injury induced by ceramide. Intrinsic cochlear ceramide kinase protected the cochlea against ototoxicity.
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Report
(6 results)
Research Products
(9 results)
