Evaluation of degeneration and regeneration process of human fungiform taste buds after severing the chorda tympani nerve using confocal laser scanning microscopy in vivo
| Project/Area Number |
24592543
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NARITA Norihiko 福井大学, 医学部附属病院, 講師 (80345678)
ITO Tetsufumi 福井大学, 医学部, 助教 (90334812)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 鼓索神経 / 中耳手術 / 茸状乳頭 / 味蕾 / 退縮 / 再生 / 神経切断 / 味蕾の退縮 / 味蕾の再生 / 共焦点レーザー顕微鏡 |
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| Outline of Final Research Achievements |
Subjects were seven patients with severed chorda tympani nerve during tympanoplasty for middle ear cholesteatoma. Electrogustometry (EGM) and confocal laser scanning microscopy in vivo were performed pre- and postoperatively to investigate taste function and morphology of fungiform taste buds (TB). TB was completely disappeared 2 to 10 weeks (50 days in average) after severing the nerve. Thereafter, these 7 patients were periodically followed for 1 to 2 years. Regeneration of the TB was firstly observed in 5 cases 5 to 8 months after surgery. In 2 cases, regenerated TB continued to increase and EGM threshold was recovered to preoperative value. In 3 cases, regenerated TB was detected but taste function never recovered. In other 2 cases, both regeneration of TB and recovery of EGM threshold could not be observed.
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Report
(4 results)
Research Products
(8 results)
