Tranlational research for the improved outcome and the broader indication of the cochlear implantation
| Project/Area Number |
24592545
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyoto University |
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Principal Investigator |
YAMAMOTO Norio 京都大学, 医学(系)研究科(研究院), 助教 (70378644)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAUMI Harukiazu 岩手医科大学, 医学部耳鼻咽喉科・頭頸部外科, 講師 (10374167)
NAKAGAWA Takayuki 京都大学, 大学院医学研究科耳鼻咽喉科・頭頸部外科, 講師 (50335270)
SAKAMOTO Tatsunori 京都大学, 大学院医学研究科耳鼻咽喉科・頭頸部外科, 助教 (60425626)
TAURA Akiko 京都大学, 大学院医学研究科耳鼻咽喉科・頭頸部外科, 助教 (70515345)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 再生医学 / 人工内耳 / IGF-1 / Septin / 内耳奇形 / 有毛細胞 / Olig / 耳科学 / トランスレーショナルリサーチ / 内耳 / 聴神経 / 遺伝子 |
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| Outline of Final Research Achievements |
1. We found that Insulin-like growth factor 1 (IGF-1) protects cochlear hair cells from injury through the inhibition of hair-cell apoptosis and supporting-cell proliferation. We identified Gap43 and Netrin1 as effector molecules of IGF-1 by performing comprehensive analysis of the gene expression within the cochlea. Among these two molecules, Netrin1 had similar effects with IGF-1 on injured cochlear hair cells.
2. Septin7 constitutes the cytoskeleton and exerts various functions. We analyzed the phenotypes of Septin7 knockout mice. The inner ears of the mice had severe hypomorphic malformation. However, sensory epithelium developed within the inner ear and the epithelium was innervated by the auditory nerve. The proliferation of the mutant inner ear was normal although apoptosis was promoted.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment.2014
Author(s)
Nakagawa T., Kumakawa K., Usami S., Hato N., Tabuchi K., Takahashi M., Fujiwara K., Sasaki A., Komune S., Sakamoto T., Hiraumi H., Yamamoto N., Tanaka S., Tada H., Yamamoto M., Yonezawa A., Ito-Ihara T., Ikeda T., Shimizu A., Tabata Y., and Ito J.
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Journal Title
BMC Med
Volume: 12
Issue: 1
Pages: 219-219
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model.2013
Author(s)
Toritsuka M, Kimoto S, Muraki K, Landek-Salgado MA, Yoshida A, Yamamoto N, Horiuchi Y, Hiyama H, Tajinda K, Keni N, Illingworth E, Iwamoto T, Kishimoto T, Sawa A, Tanigaki K.
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Journal Title
Proc Natl Acad Sci U S A
Volume: 110
Issue: 43
Pages: 17552-17557
DOI
Related Report
Peer Reviewed
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[Presentation] Septinの内耳発生における役割2014
Author(s)
山本典生 鳥居紘子 吉田充裕 中川隆之 伊藤壽一
Organizer
第24回日本耳科学会総会・学術講演会
Place of Presentation
朱鷺メッセ（新潟市）
Year and Date
2014-10-15 – 2014-10-18
Related Report
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