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Tranlational research for the improved outcome and the broader indication of the cochlear implantation

Research Project

Project/Area Number 24592545
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionKyoto University

Principal Investigator

YAMAMOTO Norio  京都大学, 医学(系)研究科(研究院), 助教 (70378644)

Co-Investigator(Kenkyū-buntansha) HIRAUMI Harukiazu  岩手医科大学, 医学部耳鼻咽喉科・頭頸部外科, 講師 (10374167)
NAKAGAWA Takayuki  京都大学, 大学院医学研究科耳鼻咽喉科・頭頸部外科, 講師 (50335270)
SAKAMOTO Tatsunori  京都大学, 大学院医学研究科耳鼻咽喉科・頭頸部外科, 助教 (60425626)
TAURA Akiko  京都大学, 大学院医学研究科耳鼻咽喉科・頭頸部外科, 助教 (70515345)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords再生医学 / 人工内耳 / IGF-1 / Septin / 内耳奇形 / 有毛細胞 / Olig / 耳科学 / トランスレーショナルリサーチ / 内耳 / 聴神経 / 遺伝子
Outline of Final Research Achievements

1. We found that Insulin-like growth factor 1 (IGF-1) protects cochlear hair cells from injury through the inhibition of hair-cell apoptosis and supporting-cell proliferation. We identified Gap43 and Netrin1 as effector molecules of IGF-1 by performing comprehensive analysis of the gene expression within the cochlea. Among these two molecules, Netrin1 had similar effects with IGF-1 on injured cochlear hair cells.
2. Septin7 constitutes the cytoskeleton and exerts various functions. We analyzed the phenotypes of Septin7 knockout mice. The inner ears of the mice had severe hypomorphic malformation. However, sensory epithelium developed within the inner ear and the epithelium was innervated by the auditory nerve. The proliferation of the mutant inner ear was normal although apoptosis was promoted.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (36 results)

All 2015 2014 2013 2012

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (22 results) (of which Invited: 5 results)

  • [Journal Article] Expression of the Olig gene family in the developing mouse inner ear2015

    • Author(s)
      Kanaya E, Yamahara K, Okano T, Yoshida A, Katsuno T, Takebayashi H, Ito J, Yamamoto N
    • Journal Title

      Gene Expr Patterns

      Volume: 17 Issue: 2 Pages: 79-86

    • DOI

      10.1016/j.gep.2015.03.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment.2014

    • Author(s)
      Nakagawa T., Kumakawa K., Usami S., Hato N., Tabuchi K., Takahashi M., Fujiwara K., Sasaki A., Komune S., Sakamoto T., Hiraumi H., Yamamoto N., Tanaka S., Tada H., Yamamoto M., Yonezawa A., Ito-Ihara T., Ikeda T., Shimizu A., Tabata Y., and Ito J.
    • Journal Title

      BMC Med

      Volume: 12 Issue: 1 Pages: 219-219

    • DOI

      10.1186/s12916-014-0219-x

    • NAID

      120005517912

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Therapeutic potential of a gamma-secretase inhibitor for hearing restoration in a guinea pig model with noise-induced hearing loss.2014

    • Author(s)
      Tona Y., Hamaguchi K., Ishikawa M., Miyoshi T., Yamamoto N., Yamahara K., Ito J., and Nakagawa T
    • Journal Title

      BMC Neurosci

      Volume: 15 Issue: 1 Pages: 66-66

    • DOI

      10.1186/1471-2202-15-66

    • NAID

      120005456012

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Application of insulin-like growth factor-1 in the treatment of inner ear disorders2014

    • Author(s)
      Yamamoto, N. Nakagawa, T. Ito, J.
    • Journal Title

      Frontiers in pharmacology

      Volume: 5 Pages: 208-208

    • DOI

      10.3389/fphar.2014.00208

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Insulin-like growth factor 1 induces the transcription of Gap43 and Ntn1 during hair cell protection in the neonatal murine cochlea.2013

    • Author(s)
      Hayashi Y, Yamamoto N, Nakagawa T, Ito J.
    • Journal Title

      Neurosci Lett.

      Volume: 560 Pages: 7-11

    • DOI

      10.1016/j.neulet.2013.11.062

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reprogramming of mouse cochlear cells by transcription factors to generate induced pluripotent stem cells.2013

    • Author(s)
      Lou XX, Nakagawa T, Nishimura K, Ohnishi H, Yamamoto N, Sakamoto T, Ito J.
    • Journal Title

      Cell Reprogram.

      Volume: 15 Issue: 6 Pages: 514-519

    • DOI

      10.1089/cell.2013.0020

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model.2013

    • Author(s)
      Toritsuka M, Kimoto S, Muraki K, Landek-Salgado MA, Yoshida A, Yamamoto N, Horiuchi Y, Hiyama H, Tajinda K, Keni N, Illingworth E, Iwamoto T, Kishimoto T, Sawa A, Tanigaki K.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 110 Issue: 43 Pages: 17552-17557

    • DOI

      10.1073/pnas.1312661110

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E receptor subtype EP4 agonist serves better to protect cochlea than prostaglandin E1.2013

    • Author(s)
      Hori R, Nakagawa T, Yamamoto N, Hamaguchi K, Ito J.
    • Journal Title

      Auris Nasus Larynx

      Volume: 40 Issue: 6 Pages: 539-542

    • DOI

      10.1016/j.anl.2013.05.003

    • NAID

      120005323027

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rapid detection of bacterial DNA in mastoid granulation tissue with nested-PCR technique.2013

    • Author(s)
      Eiamprapai P, Matsumura Y, Hiraumi H, Yamamoto N, Takakura S, Ito J.
    • Journal Title

      J Med Assoc Thai

      Volume: 96 Pages: 460-466

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Insulin-like growth factor 1 inhibits hair cell apoptosis and promotes the cell cycle of supporting cells by activating different downstream cascades after pharmacological hair cell injury in neonatal mice.2013

    • Author(s)
      Hayashi Y, Yamamoto N, Nakagawa T, Ito J.
    • Journal Title

      Mol Cell Neurosci

      Volume: 56 Pages: 29-38

    • DOI

      10.1016/j.mcn.2013.03.003

    • NAID

      120005244788

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of tympanic border cells as slow-cycling cells in the cochlea.2012

    • Author(s)
      Mirei Taniguchi
    • Journal Title

      Plos One

      Volume: 7 Issue: 10 Pages: e48544-e48544

    • DOI

      10.1371/journal.pone.0048544

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Audiometric outcomes of topical IGF1 treatment for sudden deafness refractory to systemic steroids.2012

    • Author(s)
      Takayuki Nakagawa
    • Journal Title

      Otol Neurotol

      Volume: 33 Issue: 6 Pages: 941-946

    • DOI

      10.1097/mao.0b013e31825f251a

    • NAID

      120005323028

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hear Res Localization of septin proteins in the mouse cochlea2012

    • Author(s)
      Yoshida A, Yamamoto N, Kinoshita M, Hiroi N, Hiramoto T, Kang G, Trimble WS, Tanigaki K, Nakagawa T, Ito J.
    • Journal Title

      Epub ahead of print

      Volume: 289 Issue: 1-2 Pages: 40-51

    • DOI

      10.1016/j.heares.2012.04.015

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of cisplatin on distortion product otoacoustic emissions in Japanese patients.2012

    • Author(s)
      Eiamprapai P, Yamamoto N, Hiraumi H, Ogino-Nishimura E, Kitamura M, Hirano S, Ito J.
    • Journal Title

      Laryngoscope

      Volume: 122 Issue: 6 Pages: 1392-1396

    • DOI

      10.1002/lary.23336

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Application of Insulin-Like Growth Factor-1 in the Treatment of Inner Ear Disorders2015

    • Author(s)
      Norio Yamamoto
    • Organizer
      2015 International Congress of Korean Society of Otorhinolaryngology-Head & Neck Surgery
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Septinの内耳発生における役割2014

    • Author(s)
      山本典生 鳥居紘子 吉田充裕 中川隆之 伊藤壽一
    • Organizer
      第24回日本耳科学会総会・学術講演会
    • Place of Presentation
      朱鷺メッセ(新潟市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 小児人工内耳新適応基準における人工内耳手術について2014

    • Author(s)
      山本典生
    • Organizer
      第24回日本耳科学会総会・学術講演会
    • Place of Presentation
      朱鷺メッセ(新潟市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 再生医療から見た音声言語医学の未来 人工内耳と再生医療2014

    • Author(s)
      山本典生
    • Organizer
      第59回日本音声言語医学会総会・学術講演会
    • Place of Presentation
      アクロス福岡(福岡市)
    • Year and Date
      2014-10-08 – 2014-10-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Septin7 contributes to the formation of the inner ear gross morphology2014

    • Author(s)
      Yamamoto, Norio Torii, Hiroko Kinoshita, Makoto Nakagawa, Takayuki Ito, Juichi
    • Organizer
      51st Inner Ear Biology Workshop
    • Place of Presentation
      Sheffield, UK
    • Year and Date
      2014-08-30 – 2014-09-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Estimation of the cochlear duct length for MED-EL standard electrode arrays2014

    • Author(s)
      Yamamoto, Norio Hiraumi, Harukazu Sakamoto, Tatsunori Okano, Takayuki Yamazaki, Hiroshi Ito, Juichi
    • Organizer
      13th International Conference on Cochlear Implants and Other Implantable Auditory Technologies
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 聴覚成熟期における内耳のアクアポリン発現量の変化2014

    • Author(s)
      山本典生 三好拓志 中川隆之 伊藤壽一
    • Organizer
      第115回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡市)
    • Year and Date
      2014-05-14 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Estimation of the cochlear duct length for MED-EL standard electrode arrays2014

    • Author(s)
      Yamamoto, Norio Hiraumi, Harukazu Sakamoto, Tatsunori Okano, Takayuki Yamazaki, Hiroshi Ito, Juichi
    • Organizer
      15th Korea Japan Joint Meeting of Otorhinolaryngology-Head and Neck surgery
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] IGF-1による内耳有毛保護メカニズムの解明2014

    • Author(s)
      山本典生
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Slow-Cycling Cells in Tympanic Border Cells Mostly Distribute Beneath Organs of Corti2014

    • Author(s)
      Yamamoto N, Taniguchi M, Nakagawa T, Ogino E, and Ito J
    • Organizer
      37th Annual MidWinter Meeting of the Association for Research in Otolaryngology
    • Place of Presentation
      The Manchester Grand Hyatt Hotel San Diego, California, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 聴覚再生医療の現状と未来2013

    • Author(s)
      山本典生
    • Organizer
      人工内耳友の会[ACITA] 創立25周年記念大会(第26回懇談会)
    • Place of Presentation
      東京都江戸川区 タワーホール 船堀
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Identification of tympanic border cells as slow-cycling cells in the cochlea2013

    • Author(s)
      Yamamoto N, Taniguchi M, Nakagawa T, Ogino E, and Ito J
    • Organizer
      The 50th Inner Ear Biology Workshop
    • Place of Presentation
      Alcal? de Henares, Madrid, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] Identification of tympanic border cells as slow-cycling cells in the cochlea2013

    • Author(s)
      Yamamoto N, Hayashi Y, Nakagawa T, and Ito J
    • Organizer
      9th Molecular Biology of Hearing and Deafness
    • Place of Presentation
      Palo Alto, CA USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Identification of tympanic border cells as slow-cycling cells in the cochlea2013

    • Author(s)
      Yamamoto N, Tanigushi M, Nakagawa T, Ogino E, and Ito J
    • Organizer
      The 20th World Congress of the International Federation of Oto-Rhino-Laryngological Societies
    • Place of Presentation
      COEX Convention and Exhibition Center, Seoul, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] 胎生および新生仔マウス蝸牛におけるセプチンタンパク質発現パターンの検討2013

    • Author(s)
      山本典生, 吉田充裕, 鳥居紘子, 中川隆之, 伊藤壽一
    • Organizer
      第23回日本耳科学会総会・学術講演会
    • Place of Presentation
      シーガイアコンベンションセンター 宮崎県宮崎市山崎町浜山
    • Related Report
      2013 Research-status Report
  • [Presentation] Mechanisms of Cochlear Hair Cell Protection by IGF-12013

    • Author(s)
      Norio Yamamoto, Yushi Hayashi, Takayuki Nakagawa, Juichi Ito
    • Organizer
      The 36th Annual MidWinter Meeting of the Association for Research in Otolaryngology
    • Place of Presentation
      米国 ボルチモア
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Septin Protein Expression in the Embryonic and Neonatal Mouse Cochlea2012

    • Author(s)
      Norio Yamamoto Atsuhiro Yoshida, Hiroko Torii, Takayuki Nakagawa, Juichi Ito
    • Organizer
      The Inner Ear Biology 2012 Workshop and Symposium
    • Place of Presentation
      ドイツ チュービンゲン
    • Related Report
      2012 Research-status Report
  • [Presentation] Mechanisms of mammalian cochlear hair cell protection by IGF-12012

    • Author(s)
      Norio Yamamoto, Yushi Hayashi, Takayuki Nakagwa, Juichi Ito
    • Organizer
      12th International Conference on Cochlear Implants and Other Implantable Auditory Technologies
    • Place of Presentation
      米国ボルチモア
    • Related Report
      2012 Research-status Report
  • [Presentation] A case of concurrent intra-labyrinthine schwannoma and glomus tympanicum tumor2012

    • Author(s)
      Norio Yamamoto, Mami Matsunaga, Harukazu Hiraumi, Tatsunori Sakamoto, Juichi Ito
    • Organizer
      The 9th International Conference on Cholesteatoma and Ear Surgery
    • Place of Presentation
      Nagasaki Brick Hall(長崎市)
    • Related Report
      2012 Research-status Report
  • [Presentation] Parkinノックアウトマウスにおける外有毛細胞障害メカニズムの検討2012

    • Author(s)
      山本典生、林裕史、中川隆之、伊藤壽一
    • Organizer
      第113回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      朱鷺メッセ(新潟市)
    • Related Report
      2012 Research-status Report
  • [Presentation] parkinノックアウトマウスの聴覚と若年性パーキンソン病診断への応用2012

    • Author(s)
      山本典生、濱口清海、林裕史、中川隆之、伊藤壽一
    • Organizer
      第22回日本耳科学会総会・学術講演会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 迷路内神経鞘腫と鼓室型グロームス腫瘍との同時発生例2012

    • Author(s)
      山本典生、木谷芳晴、平海晴一、坂本達則、伊藤壽一
    • Organizer
      第22回日本耳科学会総会・学術講演会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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