| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The composition and homeostasis of the inner ear fluids are important for hearing function. This study is for the first time to perform metabolome analysis of the inner ear fluid in guinea pigs cochlea using gas-chromatography/mass-spectrometry (GC/MS). Seventy-seven kinds of metabolites were detected in the inner ear fluid. Six metabolites; ascorbic acid, fructose, galactosamine, inositol, pyruvate + oxalacetic acid and meso-erythritol were significantly more abundant and nine metabolites; phosphate, valine, glycine, glycerol, ornithine, glucose, citric acid + isocitric acid, mannose and trans-4-Hydroxy-L-proline were less frequent in the inner ear fluid than in plasma. The level of ten metabolites; 3-Hydroxy-Butyrate, glycerol, fumaric acid, galactosamine, pyruvate + oxalacetic acid, phosphate, meso-erythritol, citric acid + isocitric acid, mannosea and inositol in the inner ear fluid significantly changed after loud noise exposure.
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