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Regulation of drug permeability of the blood-inner ear barrier by RNA interference method

Research Project

Project/Area Number 24592548
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionKobe University

Principal Investigator

TANIMOTO Hitoshi  神戸大学, 医学(系)研究科(研究院), 研究員 (50362786)

Co-Investigator(Kenkyū-buntansha) OTSUKI Naoki  神戸大学, 医学(系)研究科(研究院), 准教授 (40343264)
YAMASHITA Daisuke  神戸大学, 医学部附属病院, 准教授 (60306785)
KATSUNUMA Sayaka  神戸大学, 医学部附属病院, 助教 (80457043)
FUJITA Takeshi  神戸大学, 医学部附属病院, 助教 (90533711)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords内耳 / 血液-内耳関門 / 感音難聴 / RNA干渉 / claudin-5 / クローディン / ドラッグデリバリーシステム / 血液ー内耳関門 / RNA干渉
Outline of Final Research Achievements

By RNA interference method, it is possible to suppress the transcription of protein structure of the blood-inner ear barrier, and to adjust the blood-inner ear barrier barrier mechanism. For the mouse to adjust the blood-inner ear barrier barrier mechanism, intravenous drug to the systemic administration, we want to prove that the drug has reached the inner ear. It is acoustic trauma modeling gives a huge acoustic trauma, and is administered inhibit RNA interference agent through the intravenous of which is the main protein claudin-5 transcription of the blood-inner ear barrier. Then, intravenously to be administered through the brain-derived neurotrophic factor (BDNF) as a neuroprotective agent for the purpose of inner ear disorder cell regeneration. And a control mouse morphological, we went electrophysiological comparison.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report

Research Products

(4 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Sensorineural hearing loss associated with Kawasaki disease2014

    • Author(s)
      Hitoshi Tanimoto, Hitomi Shinomiya, Rie Yasui, Hirokazu Sakamoto
    • Journal Title

      Online Journal Otolaryngology

      Volume: 4 Pages: 119-125

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sensorineural Hearing Loss Associated with Kawasaki Disease2014

    • Author(s)
      Hitoshi Tanimoto, Hitomi Shinomiya, Rie Yasui, Hirokazu Sakamoto, Ken-ichi Nibu
    • Journal Title

      Otolaryngology online journal

      Volume: 4 Pages: 119-125

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 周産期に増悪した鼻副鼻腔異所性骨形成症例2015

    • Author(s)
      堅田敬太、谷本均、明松智俊
    • Organizer
      第179日本耳鼻咽喉科学会兵庫県地方部会学術講演会
    • Place of Presentation
      姫路市
    • Year and Date
      2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 聴神経腫瘍術前後の平衡機能障害と代償2013

    • Author(s)
      上原奈津美、谷本均、西川匡、土井清司、勝沼紗矢香、木村英仁、甲村英二、丹生 健一
    • Organizer
      第114回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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