| Project/Area Number |
24592549
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Kensaku 鳥取大学, 医学部, 講師 (60252847)
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| Research Collaborator |
NAKAMURA Yosuke
KAWAI Yasuaki
EZOMO Ojeiru Felix
KITANO Hiroya
HOSOGAI Masae
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 前庭 / 血圧 / 頸部固有受容器 / head-down tilt / 交感神経 / 体位変換 / 頸部屈曲 / head down tilt |
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| Outline of Final Research Achievements |
We have reported that head-down tilts (HDT) induced a transient decrease of arterial blood pressure (ABP) in rabbits. We hypothesized that vestibular apparatus and cervical proprioceptor played a role in the decrease of ABP through the suppression of renal sympathetic nerve activity (RSNA). To test this hypothesis, we examined responses of ABP and RNSA to neck flection (NF), neck extension (NE), HDT and head-up tilts (HUT) with and without bilateral vestibular lesions (VL). In anesthetized rabbits, NF and HDT induced a transient drop of ABP which was followed by a suppression of RSNA. These responses were quicker than baroreceptor reflexes. ABP increased during NE and HUT. ABP decreased during NF and HDT. VL reduced the increase of ABP during NE and HUT. In alert animals, NF, NE, HDT and HUT induced an increase of ABP. The increase of ABP became smaller a week after VL. The results suggest that vestibular organs and neck afferents affect changes in ABP during postural alterations.
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