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A study on the regeneration of projective neurons in the olfactory bulb after bone marrow transplantation and the reconstruction of the olfactory neural circuit

Research Project

Project/Area Number 24592550
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionOkayama University

Principal Investigator

NISHIZAKI Kazunori  岡山大学, 医歯(薬)学総合研究科, 教授 (90180603)

Co-Investigator(Kenkyū-buntansha) ORITA Yorihisa  岡山大学病院, 助教 (90362970)
YOSHINOBU Junko  岡山大学, 医学部, 技術専門職員 (80448224)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords嗅球 / 神経細胞再生 / 嗅覚神経路 / 骨髄移植 / 移植再生医療 / 嗅覚組織 / 神経回路 / 嗅球の投射細胞 / N-methyl-D-aspartate潅流 / 化学的脱神経 / メチマゾール / アポトーシス / 嗅覚路 / 再生 / 移植・再生医療 / 骨髄細胞
Outline of Final Research Achievements

We have demonstrated that transplanted bone marrow-derived cells differentiate into olfactory sensory cells after transplantation of bone marrow including mesenchymal stem cells. In the present study, bone marrow-derived cells differentiated not only into microglia cells, but also rarely into mitral / turfed cells. Despite its rare frequency of trans-differentiation to mitral/turfed cells, this study is thought to show the possibility of regeneration medicine using bone marrow transplantation for central olfactory disorders at the olfactory bulb. Moreover, we have performed a series of experiments using irrigation of the olfactory bulb with N-methyI-D-aspartate, repeated intraperitoneal methimazole injections, intranasal dripping of ageing or anti-ageing reagent, and the resection of the olfactory nerve to observe the reconstruction of neural circuit in the central olfactory pathway.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) (of which Invited: 1 results)

  • [Journal Article] The engraftment and differentiation of transplanted bone marrow-derived cells in the olfactory bulb after methimazole administration2013

    • Author(s)
      Noda Y, Nishizaki K, Yoshinobu J, Orita Y, Tsujigiwa H, Yamada M
    • Journal Title

      Acta Otolaryngol

      Volume: 133(9) Issue: 9 Pages: 951-956

    • DOI

      10.3109/00016489.2013.803153

    • NAID

      120005359096

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Special Lecture、 Experimental Olfactory Tissue Regeneration2012

    • Author(s)
      西﨑和則
    • Organizer
      第93回台湾耳鼻咽喉科医学会
    • Place of Presentation
      Taipei、 Taiwan
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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