A study on the regeneration of projective neurons in the olfactory bulb after bone marrow transplantation and the reconstruction of the olfactory neural circuit
| Project/Area Number |
24592550
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ORITA Yorihisa 岡山大学病院, 助教 (90362970)
YOSHINOBU Junko 岡山大学, 医学部, 技術専門職員 (80448224)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 嗅球 / 神経細胞再生 / 嗅覚神経路 / 骨髄移植 / 移植再生医療 / 嗅覚組織 / 神経回路 / 嗅球の投射細胞 / N-methyl-D-aspartate潅流 / 化学的脱神経 / メチマゾール / アポトーシス / 嗅覚路 / 再生 / 移植・再生医療 / 骨髄細胞 |
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| Outline of Final Research Achievements |
We have demonstrated that transplanted bone marrow-derived cells differentiate into olfactory sensory cells after transplantation of bone marrow including mesenchymal stem cells. In the present study, bone marrow-derived cells differentiated not only into microglia cells, but also rarely into mitral / turfed cells. Despite its rare frequency of trans-differentiation to mitral/turfed cells, this study is thought to show the possibility of regeneration medicine using bone marrow transplantation for central olfactory disorders at the olfactory bulb. Moreover, we have performed a series of experiments using irrigation of the olfactory bulb with N-methyI-D-aspartate, repeated intraperitoneal methimazole injections, intranasal dripping of ageing or anti-ageing reagent, and the resection of the olfactory nerve to observe the reconstruction of neural circuit in the central olfactory pathway.
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Report
(4 results)
Research Products
(2 results)
