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Long-term prognosis of hearing loss in patients with congental Cytomegalovirus infection

Research Project

Project/Area Number 24592555
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionFukushima Medical University

Principal Investigator

MATSUI Takamichi  福島県立医科大学, 医学部, 講師 (40404876)

Co-Investigator(Kenkyū-buntansha) SUZUTANI Tatsuo  福島県立医科大学, 微生物学, 教授 (40196895)
SATO Maki  福島県立医科大学, 小児科, 講師 (50423794)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords先天性サイトメガロウイルス感染症 / 聴覚障害 / バルガンシクロビル / 進行性難聴 / 先天性サイトメガロウイルス感染 / サイトメガロウイルス感染
Outline of Final Research Achievements

Congenital CMV infection in six cases was identified by the preparation of DNA specimens from their dry umbilical cord. Four cases were identified by the blood test.Three cases were identified by urine screening. One case was identified by PCR of the lymph fluid after cochlear implant. Asymptomatic congenital CMV infection was two cases. We perform an exact audiometric test including ASSR semiannually following up this 2 case, but do not show the hearing impairment.As for seven cases of the severe hearing impairment, cochlear implant surgery was performed. An effect of the cochlear implant was shown in all cases after surgery.
Three patients received valganciclovir internal use treatment of the antiviral drug. One patient has not yet shown the hearing impairment, we should continue routine follow-up strictly.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2015 2013

All Journal Article (2 results) Presentation (3 results)

  • [Journal Article] ウイルス感染と聴覚障害~病態と診断・治療~2015

    • Author(s)
      松井隆道
    • Journal Title

      感染防止

      Volume: 25-3 Pages: 6-9

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 【見落としやすい耳鼻咽喉科疾患】 耳 小児の進行性難聴2013

    • Author(s)
      松井隆道
    • Journal Title

      ENTONI

      Volume: 157 Pages: 17-21

    • Related Report
      2013 Research-status Report
  • [Presentation] ウイルス感染と聴覚障害2015

    • Author(s)
      松井隆道
    • Organizer
      感染防止研究会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2015-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新生児聴覚スクリーニングと小児人工内耳2015

    • Author(s)
      松井隆道
    • Organizer
      日本耳鼻咽喉科学会福島県地方部会学術講演会
    • Place of Presentation
      福島県福島市
    • Year and Date
      2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 小児難聴 当院での取り組み2015

    • Author(s)
      松井隆道
    • Organizer
      第83回会津小児科医会講演会
    • Place of Presentation
      福島県会津若松市
    • Year and Date
      2015-03-10
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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