A primate model for hearing research using non-human primate common marmoset
| Project/Area Number |
24592560
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | トランスレーショナルリサーチ / 感音難聴 / 聴覚障害 / 霊長類モデル / コモンマーモセット / 耳科学 / 聴覚医学 / 実験動物学 / 橋渡し研究 / 非臨床POC / 音響外傷 / 疾患モデル |
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| Outline of Final Research Achievements |
Model animals are indispensable for the success in translational research but there are always species differences in between rodent models, commonly used for ENT/audiology research to achieve non-clinical proof of concept studies, and human cases. Notably, this discrepancy may often lead to failures in the drug development. In the study, we are trying to establish a primate deafness model using a small non-human primate common marmoset to mind the species gap. We revealed a local anatomy of temporal bone, surgical roots for the drug discovery to the inner ear via semicircular canal and round window niche, basic information in its audiology. We prepared for the ABR and OAE recording, animal facility and OR for marmosets. We are going to achieve a noise-induced hearing loss model in the species near future.
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Report
(5 results)
Research Products
(37 results)
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[Presentation] Novel in vivo Imaging Analysis of an Inner Ear Drug Delivery System in Mice: Comparison of Inner Ear Drug Concentrations over Time after Transtympanic and Systemic Injections
Author(s)
Sho Kanzaki, Masato Fujioka, Akimasa Yasuda, Shinsuke Shibata, Masaya Nakamura, Hirotaka, James Okano, Kaoru Ogawa, Hideyuki Okano
Organizer
The 12th Taiwan-Japan Conference on Otolaryngology-Head and Neck Surgery
Place of Presentation
NTUH International Convention Center, Taipei, Taiwan
Related Report
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[Presentation] 遺伝子改変マウスを用いた蝸牛有毛細胞脱落による耳鳴発症に関する検討
Author(s)
藤岡 正人, 渡部 高久, 神崎 晶, 大石 直樹, 南 修司郎, 新田 清一, 稲垣 洋三, 若林 聡子, 山田 浩之, 小島 敬史, 土橋 奈々, 細谷 誠, 和佐野 浩一郎, 水足 邦雄, 小川 郁
Organizer
第23回日本耳科学科総会・学術講演会
Place of Presentation
シーガイアコンベンションセンター
Related Report
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[Presentation] Novel in vivo imaging analysis of an inner ear (spiral ganglion) drug delivery system in mice
Author(s)
Sho Kanzaki, Masato Fujioka, Akimasa Yasuda, Shinsuke Shibata, Masaya Nakamura, Hirotaka, James Okano, Kaoru Ogawa, Hideyuki Okano
Organizer
Politzer Society Meeting
Place of Presentation
Susesi Hotel, Antalya, Turkey
Related Report
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