| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
Model animals are indispensable for the success in translational research but there are always species differences in between rodent models, commonly used for ENT/audiology research to achieve non-clinical proof of concept studies, and human cases. Notably, this discrepancy may often lead to failures in the drug development. In the study, we are trying to establish a primate deafness model using a small non-human primate common marmoset to mind the species gap. We revealed a local anatomy of temporal bone, surgical roots for the drug discovery to the inner ear via semicircular canal and round window niche, basic information in its audiology. We prepared for the ABR and OAE recording, animal facility and OR for marmosets. We are going to achieve a noise-induced hearing loss model in the species near future.
|
