| Project/Area Number |
24592569
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ICHIHARA Takahiro 大阪医科大学, 医学部, 助教 (20624240)
Mori Atsuko 大阪医科大学, 医学部, 助教 (40368105)
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| Co-Investigator(Renkei-kenkyūsha) |
Mori Yasuko 神戸大学, 医学(系)研究科(研究院), 教授 (50343257)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | Ramsay Hunt症候群 / 顔面神経麻痺 / 水痘・帯状疱疹ウイルス / 細胞性免疫 / ワクチン / Hunt症候群 / ＥＬＩＳＰＯＴ法 / ウイルス特異的細胞性免疫能 / 帯状疱疹ウイルス / 単純ヘルペス |
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| Outline of Final Research Achievements |
We determined the median spot numbers and examined varicella zoster virus (VZV)-specific cell-mediated immunity (CMI) in patients with Hunt syndrome and with Bell's palsy using IFN-γ enzyme-linked immunospot (ELISPOT) assays. We analyzed the relationship between the value of VZV-specific CMI and days from disease onset. The median spot number in Hunt syndrome (87.3) was higher than that in Bell's palsy (62.3). Hunt syndrome showed a strong relationship between the ELISPOT count and days from onset. Within the first 5 days from onset, no ELISPOT counts higher than 80 were observed. These results suggest that VZV-specific CMI in Hunt syndrome is low at disease onset and increases rapidly thereafter. Consequently, reduced VZV-specific CMI may play an important role in the reactivation of VZV in the facial nerve, leading to Hunt syndrome
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