Participation in olfactory mucosa disorder of the airway remodeling-Elucidation of hypersecretions in the olfactory mucosa of eosinophilic sinusitis
| Project/Area Number |
24592579
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKAMI Satoru 獨協医科大学, 耳鼻咽喉・頭頸部外科, 准教授 (00311944)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 嗅覚障害 / 嗅粘膜 / 分泌過多 / 好酸球 / 糖蛋白 / 三次元培養 / 好酸球性副鼻腔炎 / 複合糖質 / ボーマン腺 / NO / 内視鏡手術 |
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| Outline of Final Research Achievements |
Histopathological findings of olfactory mucosa in eosinophilic sinusitis showed eosinophil infiltration, growth of Bowman gland and excessive and abnormal secretions of Bowman gland. These reasons suggested that the olfactory mucosa adhesion of smell molecules were disturbed. After steroid admistraiton, eosinophil infiltration and growth of Boman gland were suppressed and most cases with olfactory dysfunction were improved. However, presence of steroid-resistant Amphiregulin was found in some dysosmia case in mast cells.
Respiratory Nitric acid (FeNO) was found high concentrations in respiratory mucosa with remarkable infiltrative eosinophils. Therefore, olfactory cilia dysfunction and highly secretion of Bowman gland also was suggested to be relationship with FeNO.
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Report
(4 results)
Research Products
(25 results)
