• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Participation in olfactory mucosa disorder of the airway remodeling-Elucidation of hypersecretions in the olfactory mucosa of eosinophilic sinusitis

Research Project

Project/Area Number 24592579
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionDokkyo Medical University

Principal Investigator

HARUNA shinichi  獨協医科大学, 医学部, 教授 (60198934)

Co-Investigator(Kenkyū-buntansha) FUKAMI Satoru  獨協医科大学, 耳鼻咽喉・頭頸部外科, 准教授 (00311944)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords嗅覚障害 / 嗅粘膜 / 分泌過多 / 好酸球 / 糖蛋白 / 三次元培養 / 好酸球性副鼻腔炎 / 複合糖質 / ボーマン腺 / NO / 内視鏡手術
Outline of Final Research Achievements

Histopathological findings of olfactory mucosa in eosinophilic sinusitis showed eosinophil infiltration, growth of Bowman gland and excessive and abnormal secretions of Bowman gland. These reasons suggested that the olfactory mucosa adhesion of smell molecules were disturbed. After steroid admistraiton, eosinophil infiltration and growth of Boman gland were suppressed and most cases with olfactory dysfunction were improved. However, presence of steroid-resistant Amphiregulin was found in some dysosmia case in mast cells.
Respiratory Nitric acid (FeNO) was found high concentrations in respiratory mucosa with remarkable infiltrative eosinophils. Therefore, olfactory cilia dysfunction and highly secretion of Bowman gland also was suggested to be relationship with FeNO.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (25 results)

All 2014 2013 2012

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 2 results) Presentation (14 results) (of which Invited: 12 results) Book (3 results)

  • [Journal Article] Endoscopic modified maxillectomy for odontogenic cysts and tumors2014

    • Author(s)
      Nakayama H, Haruna S
    • Journal Title

      Rhinology

      Volume: 52

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Practical guideline for management of acute rhino sinusitis in Japan2014

    • Author(s)
      Yamanaka N, Haruna S
    • Journal Title

      Auris Nasus Larynx

      Volume: 42 Issue: 2 Pages: 107-112

    • DOI

      10.1016/j.anl.2014.08.006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of B-mode ultrasonography and computed tomography in the evaluation of maxillary sinusitis in pediatric patients2014

    • Author(s)
      Mori A, Haruna S
    • Journal Title

      Nihon Jibiinkoka Gakkai Kaiho

      Volume: 117 Pages: 26-33

    • NAID

      130003395274

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endoscopic sinus surgery for chronic rhinosinusitis2013

    • Author(s)
      Haruna S
    • Journal Title

      Nihon Jibiinkoka Gakkai Kaiho

      Volume: 116 Pages: 1140-3

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surgery for sinonasal inverted papilloma2013

    • Author(s)
      Haruna S
    • Journal Title

      Nihon Jibiinkoka Gakkai Kaiho

      Volume: 116 Pages: 1007-5

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transnasal endoscopic surgery for benign orbital tumors.2013

    • Author(s)
      Haruna S
    • Journal Title

      Auris Nasus Larynx

      Volume: 40 Pages: 227-230

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term evaluation after endoscopic sinus surgery for chronic pediatric sinusitis with polyps.2012

    • Author(s)
      Tsukidate T, Haruna S
    • Journal Title

      Auris Nasus Larynx

      Volume: 39 Pages: 583-7

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 鼻閉に対する日帰り手術2012

    • Author(s)
      春名眞一
    • Journal Title

      日本耳鼻咽喉科会報

      Volume: 114 Pages: 755-60

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 好酸球性副鼻腔炎はなぜ両側性病変を呈するか2014

    • Author(s)
      春名眞一
    • Organizer
      日本鼻科学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Management of (Invasive) Fungal Diseases2014

    • Author(s)
      Haruna S
    • Organizer
      ERS & ISIAN
    • Place of Presentation
      アムステテルダム
    • Year and Date
      2014-06-22 – 2014-06-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ESSにおける合併症対策2014

    • Author(s)
      春名眞一
    • Organizer
      日本耳鼻咽喉科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-15 – 2014-05-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Image guide sinus surgery2014

    • Author(s)
      Haruna S
    • Organizer
      Japan-Korea Otorhinolyngology
    • Place of Presentation
      ソウル
    • Year and Date
      2014-04-05 – 2014-04-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Endoscopic Reviison Sinus surgery2013

    • Author(s)
      Haruna S
    • Organizer
      2nd Meeting of European Academy
    • Place of Presentation
      ニース
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Endoscopic closure of skull base defect2013

    • Author(s)
      Haruna S
    • Organizer
      IFOS
    • Place of Presentation
      ソウル
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Surgical management for chronic pediatric sinusitis with polyps2013

    • Author(s)
      Haruna S
    • Organizer
      IFOS
    • Place of Presentation
      ソウル
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Septal reconstruction of nasa septum2013

    • Author(s)
      Haruna S
    • Organizer
      3rd south pacific ORL forum
    • Place of Presentation
      マウイ
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Endoscopic Frontal Surgery2013

    • Author(s)
      Haruna S
    • Organizer
      Asia Resarch Symposium
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Revision surgery and treatment of eosinophilic sinusitis2012

    • Author(s)
      Haruna Shinichi
    • Organizer
      5th World Congress for endoscopic surgery of the brain,skull base &spine combined the first global update on FESS, the sunuses & the nose
    • Place of Presentation
      Vinne
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Endoscopic sinus surgery including (Revision) Eosinophilic sinusitis2012

    • Author(s)
      Haruna Shinichi
    • Organizer
      24th Congress of the ERS and 31th ISIAN
    • Place of Presentation
      Toulouse
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Clinical evidence for Macrolide Therapy in Chronic Rhinosinusitis and SOM2012

    • Author(s)
      Haruna Shinichi
    • Organizer
      APAC
    • Place of Presentation
      Seoul
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Transnasal Endosocpic Surgery for Benign Orbital Tumor2012

    • Author(s)
      Haruna s
    • Organizer
      Korea-Japan Otorhinolaryngology
    • Place of Presentation
      Kyoto
    • Related Report
      2012 Research-status Report
  • [Presentation] 鼻副鼻腔乳頭腫に対する手術的治療2012

    • Author(s)
      春名眞一
    • Organizer
      第113回日本耳鼻咽喉科学会
    • Place of Presentation
      新潟
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] JOHNS2013

    • Author(s)
      中山次久、春名眞一
    • Publisher
      東京医学社
    • Related Report
      2013 Research-status Report
  • [Book] ENTONI2013

    • Author(s)
      中島逸男、春名眞一
    • Publisher
      全日本出版社
    • Related Report
      2013 Research-status Report
  • [Book] 耳鼻咽喉科における病巣感染症update2012

    • Author(s)
      春名眞一
    • Total Pages
      73
    • Publisher
      全日本病院出版社
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi