Identification and functional analysis of choline transporters in respiratory tract fibroblasts
| Project/Area Number |
24592583
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
NONAKA MANABU 東京女子医科大学, 医学部, 臨床教授 (70271351)
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| Co-Investigator(Kenkyū-buntansha) |
INAZU Masato 東京医科大学, 医学部, 准教授 (00297269)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | コリントランスポーター / 線維芽細胞 / 慢性鼻副鼻腔炎 |
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| Outline of Final Research Achievements |
Choline is essential for the synthesis of major membrane phospholipid phosphatidylcholine and neurotransmitter acetylcholine. Elevated levels of choline and up-regulated choline kinase activity have been detected in cancer cells. We found that choline transporter-proteins (CTLs) are highly expressed in nasal polyp fibroblasts and are also involved in abnormal proliferation. Identification of this new CTLs-mediated choline transporter system provides a potential new target for therapeutic intervention.
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Report
(4 results)
Research Products
(2 results)
