Identification and functional analysis of choline transporters in respiratory tract fibroblasts

Research Project

Project/Area Number	24592583
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Otorhinolaryngology
Research Institution	Tokyo Women's Medical University
Principal Investigator	NONAKA MANABU 東京女子医科大学, 医学部, 臨床教授 (70271351)
Co-Investigator(Kenkyū-buntansha)	INAZU Masato 東京医科大学, 医学部, 准教授 (00297269)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	コリントランスポーター / 線維芽細胞 / 慢性鼻副鼻腔炎
Outline of Final Research Achievements	Choline is essential for the synthesis of major membrane phospholipid phosphatidylcholine and neurotransmitter acetylcholine. Elevated levels of choline and up-regulated choline kinase activity have been detected in cancer cells. We found that choline transporter-proteins (CTLs) are highly expressed in nasal polyp fibroblasts and are also involved in abnormal proliferation. Identification of this new CTLs-mediated choline transporter system provides a potential new target for therapeutic intervention.