Analysis of novel roles of T cells especially T reg cells in the pathogenesis and recurrence of Rhinosinusitis with Nasal polyps
Project/Area Number |
24592584
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
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Research Institution | Nippon Medical School |
Principal Investigator |
PAWANKAR Ruby 日本医科大学, 医学部, 教授 (00287674)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | アトピー型鼻茸 / T細胞 / TSLP / IgE / periostin / ダニ抗原 / LPS / アトピー型鼻茸鼻茸 / TSLP / IgE / 鼻茸 / アトピー / Treg細胞 / Treg 細胞 |
Outline of Final Research Achievements |
CD4+CD45RO+ cells was significantly more and CD4+CD25+ FoxP3(Treg) cells were significatly less in nasal polyps(NP) of atopics and non-atopics than in nasal mucosa (NM) of allergic rhinitics (AR). Levels of IL-4, IL5, IL-10 and IFN-gamma were not different, but IL-13, TSLP, periostin, IL-33, fillagrin and IgE were greaterin NP than NM especially atopics( filaggrin similar in both NPs). There was a good positive correlation between IgE and ECP, TSLP and IgE, TSLP and ECP, periostin and IL-13 and IL-33 in NP and a negative correlation between Treg cells and IgE Mite stimulated NP expressed more IL-13, IL-33, TSLP and periostin. Co-stimulation with LPS upregulated it; LPS and IL-4 upregulated TSLP, Eotaxin and RANTES. Mite stimulated T cell supernantant upregulated RANTES, Eotaxin and TSLP from epithelial cells and co- colture o fmite stimulated T cells with autologous B cells increased IgE. Reduced T reg cells and increased Th2 cells contrubute to the progression and recurance of NPs.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] ICON: chronic rhinosinusitis.-252014
Author(s)
Bachert C, Pawankar R, Zhang L, Bunnag C, Fokkens WJ, Hamilos DL,Jirapongsananuruk O, Kern R, Meltzer EO, Mullol J, Naclerio R, Pilan R, Rhee CS, Suzaki H, Voegels R, Blaiss M
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Journal Title
World Allergy Organ J
Volume: 7 (1)
Pages: 25-25
DOI
Related Report
Peer Reviewed / Open Access
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