| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
CD4+CD45RO+ cells was significantly more and CD4+CD25+ FoxP3(Treg) cells were significatly less in nasal polyps（NP) of atopics and non-atopics than in nasal mucosa (NM) of allergic rhinitics (AR). Levels of IL-4, IL5, IL-10 and IFN-gamma were not different, but IL-13, TSLP, periostin, IL-33, fillagrin and IgE were greaterin NP than NM especially atopics( filaggrin similar in both NPs). There was a good positive correlation between IgE and ECP, TSLP and IgE, TSLP and ECP, periostin and IL-13 and IL-33 in NP and a negative correlation between Treg cells and IgE Mite stimulated NP expressed more IL-13, IL-33, TSLP and periostin. Co-stimulation with LPS upregulated it; LPS and IL-4 upregulated TSLP, Eotaxin and RANTES. Mite stimulated T cell supernantant upregulated RANTES, Eotaxin and TSLP from epithelial cells and co- colture o fmite stimulated T cells with autologous B cells increased IgE. Reduced T reg cells and increased Th2 cells contrubute to the progression and recurance of NPs.
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