| Project/Area Number |
24592591
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Hideki 福井大学, 高エネルギー医学研究センター, 准教授 (40142377)
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| Co-Investigator(Renkei-kenkyūsha) |
ITO Yumi 福井大学, 医学部附属病院, 医員 (00646458)
TAKABAYASHI Tetsuji 福井大学, 医学部, 助教 (70397272)
YAMADA Takechiyo 福井大学, 医学部附属病院, 講師 (70283182)
FUJIEDA Shigeharu 福井大学, 医学部, 教授 (30238539)
KARAYA Kazuhiro 福井大学, ライフサイエンス支援センター, 助手 (70233997)
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| Research Collaborator |
SUGIMOTO Chizuru
NOMI Nozomi
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | PCBP4 / head and neck cancer / cisplatin / resistance / G2 checkpoint / G2 checkpoint abrogation / G2check point abrogation / 頭頸部癌 / シスプラチン / Cdc25A |
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| Outline of Final Research Achievements |
The present study showed that suppression of PCBP4 by RNAi reduced cisplatin-induced G2/M arrest and enhanced apoptosis in IMC-3CR cells, resulting in the reduction of cisplatin resistance. In contrast, overexpression of PCBP4 in IMC-3 cells induced G2/M arrest after cisplatin treatment and enhanced cisplatin resistance. We revealed that PCBP4 combined with Cdc25A and suppressed the expression of Cdc25A, resulting in G2/M arrest. PCBP4 plays important roles in the induction of cisplatin resistance in human maxillary cancers. PCBP4 is a novel molecular target for the therapy of head and neck cancers, especially cisplatin-resistant cancers.
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