Investigation on the Association between the Galectin-3 Promotor Methylation Status and the Carcinogenesis in thyroid neoplasms.

• Project/Area Number: 24592596
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses
• Principal Investigator: YOSHII Tadashi 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, その他 (10521726)
• Co-Investigator(Kenkyū-buntansha): NAKAHARA Susumu 大阪大学, 大学院医学系研究科, 助教 (20625107) ; 山本 佳史 大阪大学, 医学(系)研究科(研究院), 助教 (60346210)
• Co-Investigator(Renkei-kenkyūsha): YAMAMOTO Yoshifumi 大阪大学, 大学院医学系研究科, 助教 (60346210)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ガレクチン－3 / 甲状腺癌 / ガレクチン-3

Outline of Final Research Achievements

We investigated the relationship between the Galectin-3 DNA promotor methylation status and the carcinogenesis in thyroid neoplasms. We detected the de-methylated Galectin-3 DNA in all of the specimen from thyroid papillary carcinoma, and the methylated form in all of the specimen from thyroid adenoma. Moreover, thyroid adenoma cells treated by the de-methylating agent showed not only the increased Galectin-3 expression but also the aquired phenomena of malignant transformation. These data indicated that the de-methylation of Galectin-3 DNA promotor is related in the mechanism of the carcinogenesis of thyroid neoplasms.