Analysis of Expression and Function of Podocalyxin in Head and Neck Squamous Cell Carcinoma

• Project/Area Number: 24592601
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kumamoto University
• Principal Investigator: Murakami Daizo 熊本大学, 医学部附属病院, 助教 (70398212)
• Co-Investigator(Renkei-kenkyūsha): Ryosei Minoda 熊本大学, 大学院生命科学研究部 (30284772)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 頭頸部癌 / ポドカリキシン

Outline of Final Research Achievements

A primary aim of this study is to analyze an expression of podocalyxin in head and neck squamous cell carcinoma (HNSCC) tissue and a relation between progression of HNSCC and podocalyxin. In examination with western blot and immunostaining method, we could not find the expression of podocalyxin in all HNSCC tissue. However, podocalyxin was expressed in high grade malignant mucoepidermoid carcinoma tissue which was diagnosed as SCC preoperatively. This result indicates the possibility of the expression of podocalyxin in adenocarcinoma.