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Basic and clinical research for the dynamics of swallowing in healthy individuals and unilateral vocal fold paralysis patients using high resolution manometry.

Research Project

Project/Area Number 24592602
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionKumamoto University

Principal Investigator

SAMEJIMA Yasuhiro  熊本大学, 医学部附属病院, 講師 (50206009)

Co-Investigator(Renkei-kenkyūsha) SANUKI Tetsuji  熊本大学, 医学部附属病院, 講師 (10335896)
KUMAI Yoshihiko  熊本大学, 生命科学研究部, 助教 (00555774)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords嚥下圧 / 高解像度内圧計 / マノメトリ― / 喉頭麻痺 / 嚥下リハビリテーション / 嚥下機能改善手術
Outline of Final Research Achievements

Swallowing pressure was examined by a high resolution manometry (HRM) catheter with 36 circumferential sensors (diameter: 8Fr), to establish a normal control study. These results were significantly different than those from those obtained by several previous studies of swallowing pressure. The super-supraglottic swallow had increased the pressure in velopharynx and meso-hypopharynx to expel pharyngeal residue.
Idiopathic unilateral vocal fold paralysis (UVFP) patients were more likely to demonstrate increased residue and asymmetry toward the involved region as compared with recurrent laryngeal nerve (RLN) paralysis patients, suggesting that nerve involvement in idiopathic UVFP may not be exclusive to the RLN. UVFP with lower cranial nerve paralysis had decreased the swallowing pressure in velopharynx and meso-hypopharynx. These pressures were increased after the cricopharyngeal myotomy and laryngeal suspension. HRM was useful method to evaluate the treatment.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (16 results)

All 2015 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (10 results) (of which Invited: 1 results) Remarks (2 results)

  • [Journal Article] 嚥下機能の評価法の検証 嚥下圧測定検査:ハイレゾリューションマノメトリー2015

    • Author(s)
      熊井良彦、松原慶吾、鮫島靖浩、湯本英二
    • Journal Title

      嚥下医学

      Volume: 4 Pages: 58-62

    • NAID

      40020371023

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Swallowing pressure and pressure profiles in young healthy adults.2014

    • Author(s)
      Matsubara K, Kumai Y, Samejima Y, Yumoto E
    • Journal Title

      Laryngoscope

      Volume: 124 Issue: 3 Pages: 711-717

    • DOI

      10.1002/lary.24311

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Postdeglutitive residue in idiopathic unilateral vocal fold paralysis: A quantitative videofluoroscopic study.2013

    • Author(s)
      Narajos N, Samejima Y, Kumai Y, Yumoto E
    • Journal Title

      Laryngoscope

      Volume: 123 Issue: 11 Pages: 2776-2779

    • DOI

      10.1002/lary.24132

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 2.64mm径カテーテルを用いた高解像度マノメトリによる健常者の嚥下動態に関する研究2012

    • Author(s)
      松原慶吾、鮫島靖浩、熊井良彦、湯本英二
    • Journal Title

      嚥下医学

      Volume: 1 Pages: 364-373

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 高解像度マノメトリ―による嚥下機能改善手術の評価2015

    • Author(s)
      鮫島靖浩、松原慶吾、讃岐徹治、亀之園佑太、兒玉成博、湯本英二
    • Organizer
      第38回日本嚥下医学会ならびに学術講演会
    • Place of Presentation
      福島 コラッセふくしま
    • Year and Date
      2015-02-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 正常者における嚥下圧基礎研究とその臨床応用2014

    • Author(s)
      熊井良彦、鮫島靖浩、松原慶吾、湯本英二
    • Organizer
      第66回日本気管食道科学会総会ならびに学術講演会
    • Place of Presentation
      高知市 高知県立県民文化ホール
    • Year and Date
      2014-11-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 強い息こらえ嚥下が嚥下圧動態に及ぼす影響について ―2.64mm径高解像度マノメトリ―を用いて―2014

    • Author(s)
      松原慶吾、鮫島靖浩、熊井良彦、湯本英二
    • Organizer
      第59回日本音声言語医学会総会・学術講演会
    • Place of Presentation
      福岡市 アクロス福岡
    • Year and Date
      2014-10-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Conduction curve and velocity of swallowing pressure in young healthy adults.2014

    • Author(s)
      Matsubara K, Kumai Y, Samejima Y, Yumoto E
    • Organizer
      American Laryngological Association 135th Annual Meeting
    • Place of Presentation
      米国 ラスベガス Caesar's Palace
    • Year and Date
      2014-05-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高解像度マノメトリ―により嚥下機能改善手術前後の評価を行った1例2014

    • Author(s)
      鮫島靖浩、松原慶吾、讃岐徹治、兒玉成博、亀之園佑太、湯本英二
    • Organizer
      第37回日本嚥下医学会ならびに学術講演会
    • Place of Presentation
      東京 学術総合センター
    • Related Report
      2013 Research-status Report
  • [Presentation] Swallowing pressure of normal subjects measured using high-resolution manometry with 2.64mm diameter catheter.2013

    • Author(s)
      Matsubara K, Kumai Y, Samejima Y, Yumoto E
    • Organizer
      American Laryngological Association
    • Place of Presentation
      USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 2.64mm径カテーテルを用いた高解像度マノメトリ―による健常者の嚥下動態に関する研究2013

    • Author(s)
      松原慶吾、鮫島靖浩、熊井良彦、湯本英二
    • Organizer
      第58回日本音声言語医学会・学術講演会
    • Place of Presentation
      高知市文化プラザかるぽーと
    • Related Report
      2013 Research-status Report
  • [Presentation] 頭部屈曲位が嚥下圧と上部食道括約筋に及ぼす影響 ~2.64mm径高解像度マノメトリ―を用いて~2013

    • Author(s)
      松原慶吾、鮫島靖浩、熊井良彦、湯本英二
    • Organizer
      第58回日本音声言語医学会・学術講演会
    • Place of Presentation
      高知市文化プラザかるぽーと
    • Related Report
      2013 Research-status Report
  • [Presentation] 健常者の嚥下圧伝播曲線の検討 ~2.64mm径カテーテルで高解像度マノメトリを用いて~2013

    • Author(s)
      松原慶吾、鮫島靖浩、熊井良彦、湯本英二
    • Organizer
      第36回日本嚥下医学会総会ならびに学術講演会
    • Place of Presentation
      京都市みやこめっせ
    • Related Report
      2012 Research-status Report
  • [Presentation] 2.64㎜径カテーテルで高解像度マノメトリを用いた健常者の嚥下動態に関する研究 ~男女別の嚥下圧及び嚥下圧曲線の検討~2012

    • Author(s)
      松原慶吾、鮫島靖浩、熊井良彦、湯本英二
    • Organizer
      第57回日本音声言語医学会総会・学術講演会
    • Place of Presentation
      大阪国際交流センター
    • Related Report
      2012 Research-status Report
  • [Remarks] 熊本大学 耳鼻咽喉科・頭頸部外科

    • URL

      http://www2.kuh.kumamoto-u.ac.jp/jibiinkoka/kenkyu_ronbun.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 熊本大学 耳鼻咽喉科・頭頸部外科

    • URL

      http://www2.kuh.kumamoto-u.ac.jp/jibiinkoka/kenkyu_ronbun.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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