| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
The expression levels of mRNAs encoding M-cadherin and MyoD in the TA muscle of the DNV group were significantly higher (p<0.01) than in the control throughout the study period. These mRNA levels in the ANS group were significantly higher (p<0.01) at ≦ 1week than in the controls, but fell to control levels at ≧ 3weeks. In the ANS group, recovery of muscle area and NMJ structure occurred by 3 weeks.
These data suggested that NMJ formation following reinnervation might prompt recovery of M-cadherin and MyoD mRNA expression to the quiescent level of SCs.
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