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Functional larynx preservation surgery SCL-CHEP: basic research and clinical application for better vocal and swallowing functions

Research Project

Project/Area Number 24592608
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionKitasato University

Principal Investigator

NAKAYAMA MEIJIN  北里大学, 医学部, 講師 (20207955)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords喉頭癌 / 機能温存 / 亜全摘 / 嚥下 / 音声 / 癌浸潤 / 喉頭亜全摘出術 / 喉頭機能 / 喉頭温存率 / 粗生存率 / 脂肪注入
Outline of Final Research Achievements

Supracricoid laryngectomy is a functional larynx preservation surgery indicated for intermediate and well selected advanced laryngeal cancers. It resects 3/4 of the larynx including thyroid cartilage and bilateral vocal folds; neolarynx is reconstructed utilizing the remaining 1/4 of the larynx, which are hyoid bone, cricoid and arytenoid cartilages.
Cricoarytenoid Unit is the key for the post-SCL function. Neoglottis is operated on the collaboration between epiglottis and arytenoids. Voice is generally rough but the patients can resume their works. We have conducted a basic study for a better vocal and swallowing functions. We also found that appropriate neoglottal closure is crucial for a better function. Surgical interventions required for neoglottal revision were discussed.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (15 results)

All 2015 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Book (2 results)

  • [Journal Article] One hundred supracricoid laryngectomies with cricohyoidoepiglottopexy: do we achieve better local control?2015

    • Author(s)
      Nakayama M, Miyamoto S, Seino Y, Okamoto T, Kano K, Hasebe M, Okamoto M
    • Journal Title

      Jpn J Clin Oncol

      Volume: 45 Issue: 8 Pages: 732-737

    • DOI

      10.1093/jjco/hyv072

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Salvage supracricoid laryngectomy after failed radiotherapy and partial laryngectomy2015

    • Author(s)
      Nakayama M, Miyamoto S, Okabe S, Okamoto M
    • Journal Title

      The Journal of Laryngology & Otology

      Volume: 129 Issue: 1 Pages: 101-105

    • DOI

      10.1017/s0022215114003235

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clinical outcomes of 849 laryngeal cancers treated in the past 40 years: Are we succeeding?2014

    • Author(s)
      Nakayama, M., Okamoto, M., Hayakawa, K., Miyamoto, S., Ishiyama, H., Komori, S., Okamoto, T., Seino, Y., Kano, K. Soda, I., Sekiguchi, A., Kawakami, S.
    • Journal Title

      Jpn J Clin Oncol

      Volume: 44(1) Issue: 1 Pages: 57-64

    • DOI

      10.1093/jjco/hyt162

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A clinical study of transoral pharyngectomies to treat superficial hypopharyngeal cancers.2013

    • Author(s)
      Nakayama, M., Katada, C., Mikami, T., Okamoto, M., Koizumi, W., Tanabe, s., Miyamoto, S., Okamoto, T., Seino, Y., Kano, K.
    • Journal Title

      Jpn J Clin Oncol

      Volume: 43(8) Issue: 8 Pages: 782-787

    • DOI

      10.1093/jjco/hyt081

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical outcome of supracricoid laryngectomy with cricohyoidoepiglottopexy: Radiation failure versus previously untreated patients.2013

    • Author(s)
      Nakayama M, Okamoto M, Hayakawa K, Ishiyama H, Kotani S, Miyamoto S, Seino Y, Okamoto T, Soda I, Sekiguchi A.
    • Journal Title

      Auris Nasus Larynx

      Volume: 40(2): Issue: 2 Pages: 207-210

    • DOI

      10.1016/j.anl.2012.07.014

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Buccal fat augmentation for insufficient neoglottal closure after supracricoid laryngectomy with cricohyoidoepiglottopexy.2012

    • Author(s)
      Nakayama, M., Watanabe, A., Matsuki, T., Tamura, E., Seino, Y., Okabe, S., Okamoto, T., Miyamoto, S., Okamoto, M.
    • Journal Title

      Auris Nasus Larynx

      Volume: e-publication Issue: 5 Pages: 1-6

    • DOI

      10.1016/j.anl.2012.09.001

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Supracricoid laryngectomy: 17 years’ experience in Japan.2015

    • Author(s)
      中山明仁
    • Organizer
      3rd World Congress on Larynx Cancer
    • Place of Presentation
      オーストラリア・ケアンズ
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Clinical outcomes of 849 laryngeal cancers treated in the past 40 years: Are we succeeding?2014

    • Author(s)
      Meijin Nakayama, Shunsuke Miyamoto, Yutomo Seino, Koichi Kano, Tabito Okamoto, Makito Okamoto
    • Organizer
      SFORL Annual meeting
    • Place of Presentation
      PARIS, FRANCE
    • Year and Date
      2014-10-10 – 2014-10-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Clinicopathologic analyses of local recurrence after supracricoid laryngectomy with cricohyoidoepiglottopexy.2014

    • Author(s)
      Meijin Nakayama, Shunsuke Miyamoto, Koichi Kano, Yutomo Seino, Tabito Okamoto, Makito Okamoto
    • Organizer
      IFHNOS
    • Place of Presentation
      NEW YORK, US
    • Year and Date
      2014-07-25 – 2014-07-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Autologous fat augmentation for insufficient neoglottal closure after SCL-CHEP: A preliminary report.2012

    • Author(s)
      Meijin Nakayama
    • Organizer
      14th Japan-Korea ORL-HNS meeting
    • Place of Presentation
      Kyoto
    • Related Report
      2012 Research-status Report
  • [Presentation] Supracricoid laryngectomy in the era of chemoradiotherapy.

    • Author(s)
      Meijin Nakayama
    • Organizer
      12th Taiwan-Japan Conference on Otolaryngology-Head and Neck Surgery.
    • Place of Presentation
      Taipei
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Advanced laryngeal cancer: Current treatment background and the future direction.

    • Author(s)
      Meijin Nakayama
    • Organizer
      18th World Congress Joint Meeting of the Association for Bronchology and Interventional Pulmonology & the International Bronchoesophagology Society.
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Chirurgie laryngée supracricoïdienne de rattrapage après radiothérapie: l’expérience japonaise.

    • Author(s)
      Meijin Nakayama
    • Organizer
      SFORL Annual meeting
    • Place of Presentation
      Paris
    • Related Report
      2012 Research-status Report
  • [Book] 耳鼻咽喉科てこずった症例のブレークスルー2013

    • Author(s)
      中山明仁、岡本牧人(本庄 巖編)
    • Total Pages
      257
    • Publisher
      中山書店
    • Related Report
      2013 Research-status Report
  • [Book] 腫瘍性疾患診療NAVI 7喉頭癌.2012

    • Author(s)
      中山明仁
    • Total Pages
      4
    • Publisher
      耳喉頭頸
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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