Functional larynx preservation surgery SCL-CHEP: basic research and clinical application for better vocal and swallowing functions

• Project/Area Number: 24592608
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kitasato University
• Principal Investigator: NAKAYAMA MEIJIN 北里大学, 医学部, 講師 (20207955)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 喉頭癌 / 機能温存 / 亜全摘 / 嚥下 / 音声 / 癌浸潤 / 喉頭亜全摘出術 / 喉頭機能 / 喉頭温存率 / 粗生存率 / 脂肪注入

Outline of Final Research Achievements

Supracricoid laryngectomy is a functional larynx preservation surgery indicated for intermediate and well selected advanced laryngeal cancers. It resects 3/4 of the larynx including thyroid cartilage and bilateral vocal folds; neolarynx is reconstructed utilizing the remaining 1/4 of the larynx, which are hyoid bone, cricoid and arytenoid cartilages.
Cricoarytenoid Unit is the key for the post-SCL function. Neoglottis is operated on the collaboration between epiglottis and arytenoids. Voice is generally rough but the patients can resume their works. We have conducted a basic study for a better vocal and swallowing functions. We also found that appropriate neoglottal closure is crucial for a better function. Surgical interventions required for neoglottal revision were discussed.

Research Products

• [Journal Article] One hundred supracricoid laryngectomies with cricohyoidoepiglottopexy: do we achieve better local control? (2015)
  • Author(s): Nakayama M, Miyamoto S, Seino Y, Okamoto T, Kano K, Hasebe M, Okamoto M
  • Journal Title: Jpn J Clin Oncol Volume: 45 Issue: 8 Pages: 732-737
  • DOI: 10.1093/jjco/hyv072
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Salvage supracricoid laryngectomy after failed radiotherapy and partial laryngectomy (2015)
  • Author(s): Nakayama M, Miyamoto S, Okabe S, Okamoto M
  • Journal Title: The Journal of Laryngology & Otology Volume: 129 Issue: 1 Pages: 101-105
  • DOI: 10.1017/s0022215114003235
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinical outcomes of 849 laryngeal cancers treated in the past 40 years: Are we succeeding? (2014)
  • Author(s): Nakayama, M., Okamoto, M., Hayakawa, K., Miyamoto, S., Ishiyama, H., Komori, S., Okamoto, T., Seino, Y., Kano, K. Soda, I., Sekiguchi, A., Kawakami, S.
  • Journal Title: Jpn J Clin Oncol Volume: 44(1) Issue: 1 Pages: 57-64
  • DOI: 10.1093/jjco/hyt162
  • Peer Reviewed
• [Journal Article] A clinical study of transoral pharyngectomies to treat superficial hypopharyngeal cancers. (2013)
  • Author(s): Nakayama, M., Katada, C., Mikami, T., Okamoto, M., Koizumi, W., Tanabe, s., Miyamoto, S., Okamoto, T., Seino, Y., Kano, K.
  • Journal Title: Jpn J Clin Oncol Volume: 43(8) Issue: 8 Pages: 782-787
  • DOI: 10.1093/jjco/hyt081
  • Peer Reviewed
• [Journal Article] Clinical outcome of supracricoid laryngectomy with cricohyoidoepiglottopexy: Radiation failure versus previously untreated patients. (2013)
  • Author(s): Nakayama M, Okamoto M, Hayakawa K, Ishiyama H, Kotani S, Miyamoto S, Seino Y, Okamoto T, Soda I, Sekiguchi A.
  • Journal Title: Auris Nasus Larynx Volume: 40(2): Issue: 2 Pages: 207-210
  • DOI: 10.1016/j.anl.2012.07.014
  • Peer Reviewed
• [Journal Article] Buccal fat augmentation for insufficient neoglottal closure after supracricoid laryngectomy with cricohyoidoepiglottopexy. (2012)
  • Author(s): Nakayama, M., Watanabe, A., Matsuki, T., Tamura, E., Seino, Y., Okabe, S., Okamoto, T., Miyamoto, S., Okamoto, M.
  • Journal Title: Auris Nasus Larynx Volume: e-publication Issue: 5 Pages: 1-6
  • DOI: 10.1016/j.anl.2012.09.001
  • Peer Reviewed
• [Presentation] Supracricoid laryngectomy: 17 years’ experience in Japan. (2015)
  • Author(s): 中山明仁
  • Organizer: 3rd World Congress on Larynx Cancer
  • Place of Presentation: オーストラリア・ケアンズ
  • Year and Date: 2015-07-28
  • Int'l Joint Research / Invited
• [Presentation] Clinical outcomes of 849 laryngeal cancers treated in the past 40 years: Are we succeeding? (2014)
  • Author(s): Meijin Nakayama, Shunsuke Miyamoto, Yutomo Seino, Koichi Kano, Tabito Okamoto, Makito Okamoto
  • Organizer: SFORL Annual meeting
  • Place of Presentation: PARIS, FRANCE
  • Year and Date: 2014-10-10 – 2014-10-17
• [Presentation] Clinicopathologic analyses of local recurrence after supracricoid laryngectomy with cricohyoidoepiglottopexy. (2014)
  • Author(s): Meijin Nakayama, Shunsuke Miyamoto, Koichi Kano, Yutomo Seino, Tabito Okamoto, Makito Okamoto
  • Organizer: IFHNOS
  • Place of Presentation: NEW YORK, US
  • Year and Date: 2014-07-25 – 2014-07-31
• [Presentation] Autologous fat augmentation for insufficient neoglottal closure after SCL-CHEP: A preliminary report. (2012)
  • Author(s): Meijin Nakayama
  • Organizer: 14th Japan-Korea ORL-HNS meeting
  • Place of Presentation: Kyoto
• [Presentation] Supracricoid laryngectomy in the era of chemoradiotherapy.
  • Author(s): Meijin Nakayama
  • Organizer: 12th Taiwan-Japan Conference on Otolaryngology-Head and Neck Surgery.
  • Place of Presentation: Taipei
  • Invited
• [Presentation] Advanced laryngeal cancer: Current treatment background and the future direction.
  • Author(s): Meijin Nakayama
  • Organizer: 18th World Congress Joint Meeting of the Association for Bronchology and Interventional Pulmonology & the International Bronchoesophagology Society.
  • Place of Presentation: Kyoto
  • Invited
• [Presentation] Chirurgie laryngée supracricoïdienne de rattrapage après radiothérapie: l’expérience japonaise.
  • Author(s): Meijin Nakayama
  • Organizer: SFORL Annual meeting
  • Place of Presentation: Paris
• [Book] 耳鼻咽喉科てこずった症例のブレークスルー (2013)
  • Author(s): 中山明仁、岡本牧人（本庄 巖編）
  • Total Pages: 257
  • Publisher: 中山書店
• [Book] 腫瘍性疾患診療NAVI 7喉頭癌. (2012)
  • Author(s): 中山明仁
  • Total Pages: 4
  • Publisher: 耳喉頭頸