Development of cancer/testis antigen, TEX101-targeted therapy in head and neck squamous cell carcinoma
Project/Area Number |
24592609
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
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Research Institution | Juntendo University (2013-2014) Nippon Medical School (2012) |
Principal Investigator |
YOSHITAKE HIROSHI 順天堂大学, 医学(系)研究科(研究院), 非常勤講師 (00396574)
|
Co-Investigator(Kenkyū-buntansha) |
ARAKI Yoshihiko 順天堂大学, 医学研究科, 准教授 (70250933)
YOKOI Hidenori 杏林大学, 医学部, 准教授 (80317487)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | TEX101 / Ly6k / 癌・精巣抗原 / 頭頸部癌 / GPIアンカー型タンパク質 / 癌精巣抗原 / 癌マーカー |
Outline of Final Research Achievements |
A novel cancer/testis antigen, TEX101 is required for migration of spermatozoa from the uterus into the oviduct. This molecule plays a role in this biological process as an effector molecule, presumably with ADAM3. Accordingly, these experimental results suggest that TEX101 may be a regulator of cell adhesion and migration. In addition, TEX101 was associated with Ly6k on the surface of germ cells, and these molecules were co-factors that contribute to the molecular stability of TEX101/Ly6k complex. Although associate molecule(s) of TEX101 in cancer cells still remain to be unidentified, TEX101-related molecules would be potential biological markers as targets for cancer therapy.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Maternal peripheral blood natural killer cells incorporate placenta-associated microRNAs during pregnancy.2015
Author(s)
Ishida Y, Zhao D, Ohkuchi A, Kuwata T, Yoshitake H, Yuge K, Takizawa T, Matsubara S, Suzuki M, Saito S, Takizawa T
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Journal Title
Int J Mol Med.
Volume: 35
Issue: 6
Pages: 1511-1524
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Human exosomal placenta-associated miR-517a-3p modulates the expression of PRKG1 mRNA in Jurkat cells.2014
Author(s)
Kambe S, Yoshitake H, Yuge K, Ishida Y, Moksed A, Takizawa T, Kuwata T, Ohkuchi A, Matsubara S, Suzuki M, Takeshita T, Saito S, Takizawa T
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Journal Title
Biol Reprod
Volume: 91
Issue: 5
Pages: 129-129
DOI
Related Report
Peer Reviewed
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[Journal Article] A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development.2014
Author(s)
Sherman-Baust CA, Kuhn E, Valle BL, Shih IeM, Kurman RJ, Wang TL, Amano T, Ko MS, Miyoshi I, Araki Y, Lehrmann E, Zhang Y, Becker KG, Morin PJ
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Journal Title
J Pathol
Volume: 233(3)
Issue: 3
Pages: 228-237
DOI
Related Report
Peer Reviewed
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[Journal Article] Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma.2013
Author(s)
Yoshitake H., Yokoi H., Ishikawa H., Maruyama M., Endo S., Nojima M., Yoshida K., Yoshikawa H., Suzuki F., Takamori K., Fujiwara H., Araki Y.
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Journal Title
Cancer Biomark
Volume: 12
Issue: 10
Pages: 141-148
DOI
Related Report
Peer Reviewed
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