Head and Neck Nerve Regeneration Using Skeletal Muscle-Derived Multipotent Stem Cell Transplantation
| Project/Area Number |
24592610
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Tokai University |
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Principal Investigator |
OKAMI Kenji 東海大学, 医学部, 教授 (90223734)
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| Co-Investigator(Renkei-kenkyūsha) |
TAMAKI Tetsuro 東海大学, 医学部, 教授 (10217177)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 骨格筋間質幹細胞 / 神経再生 / 血管再生 / シート・ペレット / 顔面神経麻痺 / 幹細胞 / 顔面神経 / 副神経 |
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| Outline of Final Research Achievements |
Facial nerve injury animal model was established. A skeletal muscle-derived multipotent stem cells (Sk-MSCs) and a 3D patch transplantation system using Sk-MSC sheet-pellets were developed. The transplanted group showed significant facial nerve recovery. In addition, engrafted GFP+ cells formed complex branches of nerve-vascular networks, with differentiation into Schwann cells and perineurial/endoneurial cells, as well as vascular endothelial and smooth muscle cells. Thus, Sk-MSC sheet-pellet transplantation is potentially useful for functional reconstitution therapy of large defects in facial nerve-vascular networks.
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Report
(5 results)
Research Products
(9 results)
