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Head and Neck Nerve Regeneration Using Skeletal Muscle-Derived Multipotent Stem Cell Transplantation

Research Project

Project/Area Number 24592610
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionTokai University

Principal Investigator

OKAMI Kenji  東海大学, 医学部, 教授 (90223734)

Co-Investigator(Renkei-kenkyūsha) TAMAKI Tetsuro  東海大学, 医学部, 教授 (10217177)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords骨格筋間質幹細胞 / 神経再生 / 血管再生 / シート・ペレット / 顔面神経麻痺 / 幹細胞 / 顔面神経 / 副神経
Outline of Final Research Achievements

Facial nerve injury animal model was established. A skeletal muscle-derived multipotent stem cells (Sk-MSCs) and a 3D patch transplantation system using Sk-MSC sheet-pellets were developed. The transplanted group showed significant facial nerve recovery. In addition, engrafted GFP+ cells formed complex branches of nerve-vascular networks, with differentiation into Schwann cells and perineurial/endoneurial cells, as well as vascular endothelial and smooth muscle cells. Thus, Sk-MSC sheet-pellet transplantation is potentially useful for functional reconstitution therapy of large defects in facial nerve-vascular networks.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2015 2013 2012 Other

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (8 results) (of which Invited: 3 results)

  • [Journal Article] Reconstruction of Multiple Facial Nerve Branches Using Skeletal Muscle-Derived Multipotent Stem Cell Sheet-Pellet Transplantation2015

    • Author(s)
      Kosuke Saito
    • Journal Title

      PLOS ONE

      Volume: September 15 Issue: 9 Pages: 1-15

    • DOI

      10.1371/journal.pone.0138371

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 骨格筋間質由来多能性幹細胞シート・ペレットによる顔面神経ネットワークの再生2015

    • Author(s)
      齋藤 弘亮,大上研二
    • Organizer
      第116回日本耳鼻咽喉k学会総会・学術講演会
    • Place of Presentation
      東京フォーラム(東京都千代田区)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 骨格筋間質由来多能性幹細胞シート・ペレットによる 顔面神経ネットワークの再生2015

    • Author(s)
      斎藤弘亮,大上研二
    • Organizer
      第116回 日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-21 – 2015-05-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 骨格筋間質由来多能性幹細胞シート・ペレットによる損傷顔面神経ネットワークの再生と機能回復2013

    • Author(s)
      斎藤弘亮,大上研二
    • Organizer
      第114回 日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] 骨格筋間質由来多能性幹細胞を用いた顔面神経再生の試み2012

    • Author(s)
      酒井 昭博, 齋藤 弘亮, 大上 研二, 飯田 政弘, 玉木 哲朗
    • Organizer
      日本頭頸部癌学会
    • Place of Presentation
      松江市
    • Related Report
      2012 Research-status Report
  • [Presentation] 骨格筋間質由来多能性幹細胞シートペレットを用いた損傷顔面神経の再生2012

    • Author(s)
      齋藤 弘亮,酒井 昭博, 大上 研二, 飯田 政弘, 玉木 哲朗
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Research-status Report
  • [Presentation] チームアプローチによる頭頸部癌治療後のQOL改善

    • Author(s)
      大上研二
    • Organizer
      北陸頭頸部腫瘍研究会
    • Place of Presentation
      金沢市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 頭頸部癌患者のQOL改善をめざしたチームアプローチ

    • Author(s)
      大上研二
    • Organizer
      相武耳鼻科研究会
    • Place of Presentation
      厚木市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] QOL改善のための頭頸部癌チーム診療

    • Author(s)
      大上研二
    • Organizer
      第27回耳鼻科腫瘍セミナー
    • Place of Presentation
      大阪市
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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