Clinical comparison of nuclear reactor BNCT and accelerator BNCT for head and neck cancer.

• Project/Area Number: 24592611
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: University of Tsukuba (2013-2014); Kawasaki Medical School (2012)
• Principal Investigator: AIHARA Teruhito 筑波大学, 医学医療系, 准教授 (30268619)
• Co-Investigator(Kenkyū-buntansha): HIRATSUKA Jyunichi 川崎医科大学, 医学部, 教授 (30192298) ; OHNISHI Kayoko 筑波大学, 医学医療系, 講師 (60529832)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: BNCT / 進行頭頸部癌 / 再発頭頸部癌 / 機能温存 / 有害事象 / 再発病変 / 放射線抵抗性病変 / 局所制御率 / 高LET粒子線治療 / ホウ素中性子捕捉療法 / 加速器中性子源 / 原子炉中性子源 / 頭頸部癌 / ホウ素化合物 / 硼素中性子捕捉療法 / ＢＰＡ

Outline of Final Research Achievements

BNCT is effective in head and neck cancer. However, widespread skin invasion and recurrence after irradiation are risk factors for CBS after BNCT. Careful attention should be paid to the occurrence of CBS if the tumor is located adjacent to the carotid artery. The presence of skin invasion of recurrent lesions after irradiation at CBS onset is an ominous sign of lethal consequences. We must be aware of these signs to perform BNCT safely. This protocol for BNCT in recurrent and advanced head and neck cancer is promising in terms of decreasing the incidence of fatal CBS.

Research Products

• [Journal Article] BNCT for advanced or recurrent head and neck cancer. (2014)
  • Author(s): Teruhito Aihara a,b,n, Norimasa Morita b, Nobuhiko Kamitani c, Hiroaki Kumada a, Koji Ono d, Junichi Hiratsuka c, Tamotsu Harada
  • Journal Title: Applied Radiation and Isotopes Volume: 28 Pages: 12-15
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 硼素中性子捕捉療法による治療症例 手術不能耳下腺進行癌に硼素中性子捕捉療法が非常に有効であった症例(解説) (2014)
  • Author(s): 粟飯原輝人，川端 信司
  • Journal Title: PET Journal Volume: 27 Pages: 11-13
• [Journal Article] Boron neutron capture therapy outcomes for advanced or recurrent head and neck cancer (2014)
  • Author(s): Suzuki M, Kato I, Aihara T, Hiratsuka J, Yoshimura K, Niimi M, Kimura Y, Ariyoshi Y, Haginomori S, Sakurai Y, Kinashi Y, Masunaga S, et al, 計15名
  • Journal Title: J Radiat Res Volume: 55(1) Issue: 1 Pages: 146-153
  • DOI: 10.1093/jrr/rrt098
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy for advanced salivary gland carcinoma in head and neck (2013)
  • Author(s): Teruhito Aihara, Norimasa Morita, Nobuhiko Kamitani, Hiroaki Kumada, Koji Ono, Junichi Hiratsuka, Tamotu Harada.
  • Journal Title: Int J Clin Oncol Volume: 25 Issue: 3 Pages: 1-8
  • DOI: 10.1007/s10147-013-0580-3
  • Peer Reviewed / Open Access
• [Journal Article] Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer. (2012)
  • Author(s): Barth RF, Vicente MG, Harling OK, Kiger WS 3rd, Riley KJ, Binns PJ, Wagner FM, Suzuki M, Aihara T, Kato I, Kawabata S
  • Journal Title: Radiat Oncol Volume: 29 Issue: 1 Pages: 146-146
  • DOI: 10.1186/1748-717x-7-146
  • Peer Reviewed
• [Presentation] Overview of BNCT clinical studies in Japan (2014)
  • Author(s): T.Aihara
  • Organizer: Third DAAD Meeting Tsukuba – Germany “Joint research for hadron therapy”
  • Place of Presentation: University Hospital Essen
  • Year and Date: 2014-11-23 – 2014-11-28
  • Invited
• [Presentation] 頭頸部がんのBNCT -治せないがんを治す為の挑戦- (2014)
  • Author(s): 粟飯原 輝人
  • Organizer: 口腔外科 粒子線・BNCTコンソーシアム総会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2014-10-18
  • Invited
• [Presentation] A simple strategy to decrease the incidence of fatal carotid blowout syndrome after BNCT for head and neck cancers (2014)
  • Author(s): T. Aihara, N. Morita, N. Kamitani, H. Kumada, K. Oonishi, H. Ishikawa, M. Suzuki, H. Sakurai , J. Hiratsuka.
  • Organizer: 第11回日本ホウ素中性子捕捉療法学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] BNCTによる頭頸部癌治療と頸動脈破裂症候群． -BNCTを安全に行うために- (2014)
  • Author(s): 粟飯原輝人，森田倫正，神谷伸彦，熊田博明，大西かよ子，鈴木 実，平塚純一，櫻井英幸，原田 保．
  • Organizer: 第76回耳鼻咽喉科臨床学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 2014-06-26 – 2014-06-27
• [Presentation] A simple strategy to decrease the incidence of fatal carotid blowout syndrome after BNCT for head and neck cancers (2014)
  • Author(s): T. Aihara, N. Morita, N. Kamitani, H. Kumada, K. Oonishi, M. Suzuki, J. Hiratsuka, H. Sakurai.
  • Organizer: 16th International Congress on Neutron Capture Therapy
  • Place of Presentation: Helsinki, Finland
  • Year and Date: 2014-06-14 – 2014-06-19
• [Presentation] Boron-neutron capture therapy for advanced maxillary sinus cancer: two case reports (2013)
  • Author(s): Teruhito Aihara1,2, Norimasa Morita2, Hiroaki Kumada1, Hitoshi Ishikawa1, Nobuyoshi Fukumitu1, Yoshinori Sakurai4, Nobuhiko Kamitani3, Kayoko Onishi1, Toshiyuki Okumura1, Minoru Suzuki4, Junichi Hiratsuka3, Hideyuki Sakurai1.
  • Organizer: The 16th Asian Research Symposium in Rhinology
  • Place of Presentation: Tokyo
• [Presentation] Boron-neutron capture therapy for newly diagnosed head and neck cancer in initial treatment. (2013)
  • Author(s): Teruhito Aihara1,2, Norimasa Morita2, Nobuhiko Kamitani3, Hiroaki Kumada1, Nobuyoshi Fukumitu1, Yoshinori Sakurai4, Kayoko Onishi1, Minoru Suzuki4, Junichi Hiratsuka3, Hideyuki Sakurai1
  • Organizer: 7th Young Researchers’ Boron Neutron Capture Meeting
  • Place of Presentation: Granada, Spain
• [Presentation] 頭頸部進行癌における初期治療としての硼素中性子捕捉療法 (2013)
  • Author(s): 粟飯原輝人，神谷伸彦、森田倫正、宇野雅子、平塚純一、原田保．
  • Organizer: 第37回日本頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] BNCT for carotid lesion of Head and Neck Cancer. (2012)
  • Author(s): Aihara T, Morita N, Hiratsuka J, Ono K, Harada T
  • Organizer: 5thInternational Congress on Neutron Capture Therapy
  • Place of Presentation: International Congress Center(Tsukuba)
• [Presentation] 頸動脈近接病変に対する硼素中性子捕捉療法. (2012)
  • Author(s): 粟飯原 輝人，森田 倫正，宇野 雅子 ，神谷 伸彦，平塚 純一，原田 保
  • Organizer: 第36回日本頭頸部癌学会
  • Place of Presentation: 島根県民会館（松江）
• [Book] BNCT for Advanced or Recurrent Head and Neck Cancer Neutron Capture Therapy Principles and Applications. (2012)
  • Author(s): Wolfgang A.G. Sauerwein. Aihara T et.al.
  • Publisher: Springer,