Identification of a Cancer stem cell marker and therapeutic target by xenotlansplantation methods
| Project/Area Number |
24592613
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Miyagi Prefectural Hospital Organization Miyagi Cancer Center |
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Principal Investigator |
MATSUURA KAZUTO 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 特任研究員 (70271947)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Nobuyuki 地方独立法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 部長 (60280872)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 癌 / 頭頸部癌 / 超免疫不全マウス / がん幹細胞 / 癌幹細胞 |
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| Outline of Final Research Achievements |
Cancer stem cells contribute to the malignant phenotypes of a variety of cancers, but markers to identify human head and neck cancer (HNSCC) stem cells remain poorly understood. We found that CD271+ population sorted from xenotransplanted HNSCC possesses an enhanced tumor-initiating capability in immunodeficient mice. Tumors generated from the CD271+ cells contained both CD271+- positive and -negative cells, indicating that the population could undergo differentiation. In accordance with these characteristics, a stemness marker, Nanog, and matrix metalloproteinases (MMPs), which are implicated in cancer invasion, were significantly up-regulated in the CD271-positive compared to the -negative cell population. Furthermore, using primary specimens, we found that high CD271 expression was correlated with a poor prognosis for patients. Together, the present findings indicate that CD271 is a novel marker for HNSCC stem-like cells and for the prognosis.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] The role of initial neck dissection for patients with node-positive oropharyngeal squamous cell carcinomas2014
Author(s)
T. Sakashita, A. Homma, R. Hayashi, K. Kawabata, K. Yoshino, S. Iwae, Y. Hasegawa, K. Nibu, T. Kato, K. Shiga, K. Matsuura, N. Monden, M. Fuji
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Journal Title
Oral Oncology
Volume: 40
Issue: 7
Pages: 211-215
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Multi-institutional retrospective study for the evaluation of ocular function-preservation rates in maxillary sinus squamous cell carcinomas with orbital invasion.2014
Author(s)
Sakashita T, Hayashi R, Homma A, Matsuura K, Kato K, Kawabata K, Monden N, Hasegawa Y, Onitsuka T, Fujimoto Y, Iwae S, Okami K, Matsuzuka T, Yoshino K, Fujii M
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Journal Title
Head Neck.
Volume: Epub
Issue: 4
Pages: 537-542
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lymph node metastasis in T4 maxillary sinus squamous cell carcinoma: Incidence and treatment outcome.2014
Author(s)
Homma A, Hayashi R, Matsuura K, Kato K, Kawabata K, Monden N, Hasegawa Y, Onitsuka T, Fujimoto Y, Iwae S, Okami K, Matsuzuka T, Yoshino K, Nibu K, Kato T, Nishino H, Asakage T, Ota I, Kitamura M, Kubota A, Ueda T, Ikebuchi K, Watanabe A, Fujii M
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Journal Title
Ann Surg Oncol .
Volume: 21
Issue: 5
Pages: 1706-1710
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M involves Rab11-dependent EGFR recycling.2014
Author(s)
Watanuki, Z.Kosai, H., Osanai, N., Ogama, N., Mochizuki, M., Tamai, K., Yamaguchi, K., Satoh, K., Fukuhara, T., Maemondo, M., Ichinose, M., Nukiwa, T., Tanaka, N.
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Journal Title
Biochem Biophy Res Commun
Volume: 455
Issue: 3-4
Pages: 269-276
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Hepatocyte Growth Factor Regulated Tyrosine Kinase Substrate in the peripheral development and function of B-cells2014
Author(s)
Nagata T, Murata K, Murata R, Sun S-L, Saito Y, Yamaga S, Tanaka N, Tamai K, Moriya K, Kasai N, Sugamura K, and Ishii N.
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 443
Issue: 2
Pages: 351-356
DOI
Related Report
Peer Reviewed
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[Journal Article] Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer.2013
Author(s)
Endo H, Shiroki T, Nakagawa T, Yokoyama M, Tamai K, Yamanami H, Fujiya T, Sato I, Yamaguchi K, Tanaka N, Iijima K, Shimosegawa T, Sugamura K, Satoh K.
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Journal Title
PlosONE
Volume: 8
Issue: 10
Pages: e77070-e77070
DOI
Related Report
Peer Reviewed
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[Journal Article] Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma2012
Author(s)
Inoue D, Suzuki T, Mitsuishi Y, Miki Y, Suzuki S, Sugawara S, Watanabe M, Sakurada A, Endo C, Uruno A, Sasano H, Nakagawa T, Satoh K, Tanaka N, Kubo H, Motohashi H, Yamamoto M
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Journal Title
Cancer Sci
Volume: 103
Issue: 4
Pages: 760-766
DOI
Related Report
Peer Reviewed
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[Journal Article] miR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis2012
Author(s)
Ogawa T, Saiki Y, Shiga K, Chen N, Fukushige S, Sunamura M, Nagase H, Hashimoto S, Matsuura K, Saijo S, Kobayashi T, Horii A.
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Journal Title
Cancer Sci
Volume: 103
Issue: 9
Pages: 1737-1743
DOI
Related Report
Peer Reviewed
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