| Project/Area Number |
24592613
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Miyagi Prefectural Hospital Organization Miyagi Cancer Center |
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Principal Investigator |
MATSUURA KAZUTO 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 特任研究員 (70271947)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Nobuyuki 地方独立法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 部長 (60280872)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 癌 / 頭頸部癌 / 超免疫不全マウス / がん幹細胞 / 癌幹細胞 |
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| Outline of Final Research Achievements |
Cancer stem cells contribute to the malignant phenotypes of a variety of cancers, but markers to identify human head and neck cancer (HNSCC) stem cells remain poorly understood. We found that CD271+ population sorted from xenotransplanted HNSCC possesses an enhanced tumor-initiating capability in immunodeficient mice. Tumors generated from the CD271+ cells contained both CD271+- positive and -negative cells, indicating that the population could undergo differentiation. In accordance with these characteristics, a stemness marker, Nanog, and matrix metalloproteinases (MMPs), which are implicated in cancer invasion, were significantly up-regulated in the CD271-positive compared to the -negative cell population. Furthermore, using primary specimens, we found that high CD271 expression was correlated with a poor prognosis for patients. Together, the present findings indicate that CD271 is a novel marker for HNSCC stem-like cells and for the prognosis.
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