HPV infection and cancer stem-cell in EGFR target therapy for head and neck cancer
| Project/Area Number |
24592614
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | 独立行政法人国立病院機構(東京医療センター臨床研究センター) |
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Principal Investigator |
Masato Fujii 独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚平衡覚研究部, 部長 (70129633)
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| Co-Investigator(Kenkyū-buntansha) |
HABU Noboru 独立行政法人国立病院機構東京医療センター, 臨床研究センター 聴覚平衡覚研究部, 研究員 (60365369)
SON Koui 岡山大学, 医歯(薬)学総合研究所, 研究員 (40425773)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 頭頸部癌 / 癌幹細胞 / ヒト乳頭腫ウイルス / 上皮成長因子 |
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| Outline of Final Research Achievements |
SP cells as cancer stem-cell were isolated in head and neck cancer lines examined. Expression levels of Oct3/4 and Nanog were higher in SP cells than MP cells. Additionally, cell migration and invasion abilities were higher in SP cells than MP cells, whereas there was no difference in proliferation. Univariate analysis showed that expression of Oct3/4 and Nanog, vascular and muscular invasion, and mode ofinvasion were significantly correlated with delayed neck metastasis. Regarding the diagnostic performance, These results suggest that Oct3/4 and Nanog represent probable cancer stem-cell markers in HNSCC, which contribute to resistant to EGFR targeted therapy in part by enhancing cell motility and invasiveness.HPV infection was positive in 62% of 94 head and neck cancer patients.And the effect of radiotherapy and chemotherapy was better and showed good prognosis. It was suggested that cancer stem-cell markers are down regulated in HPV positive patients.
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Report
(5 results)
Research Products
(13 results)
