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Production of soluble vascular adhesion protein-1 in diabetic retinopathy

Research Project

Project/Area Number 24592615
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionHokkaido University

Principal Investigator

NODA KOUSUKE  北海道大学, 医学(系)研究科(研究院), 准教授 (90296666)

Co-Investigator(Kenkyū-buntansha) KANDA Atsuhiro  北海道大学, 大学院医学研究科, 特任講師 (80342707)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords糖尿病網膜症 / 白血球接着分子 / 酸化ストレス / VAP-1 / MMPs
Outline of Final Research Achievements

Vascular adhesion protein (VAP)-1, a multifunctional molecule with adhesive and enzymatic properties, is expressed at the surface of vascular endothelial cells of mammals. It also exists as a soluble form (sVAP-1), which is implicated in oxidative stress via its enzymatic activity. This study explores a mechanistic components to form sVAP-1 in retinal endothelial cells. Retinal capillary endothelial cells released sVAP-1 when stimulated with high glucose or inflammatory cytokines such as tumor necrosis factor-α , interleukin-1β and vascular endothelial growth factor in vitro. Furthermore, matrix metalloproteinase -2 and -9, type IV collagenases, were the key molecules to mediate the protein cleavage of VAP-1 from retinal capillary endothelial cells. Our data for the first time provide the evidence on the sVAP-1 production mediated by inflammatory cytokines and type IV collagenases in the pathogenesis of diabetic retinopathy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (19 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (11 results) (of which Invited: 3 results) Book (1 results)

  • [Journal Article] Aqueous humor levels of placental growth factor in diabetic retinopathy2014

    • Author(s)
      Ando R, Noda K, Namba S, Saito W, Kanda A, Ishida S
    • Journal Title

      Acta Ophthalmol

      Volume: 92 Issue: 3 Pages: 245-246

    • DOI

      10.1111/aos.12251

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genistein attenuates choroidal neovascularization2014

    • Author(s)
      Kinoshita S, Noda K, Tagawa Y, Inafuku S, Dong Y, Fukuhara J, Dong Z, Ando R, Kanda A, Ishida S
    • Journal Title

      J Nutr Biochem

      Volume: 25 Issue: 11 Pages: 1177-1182

    • DOI

      10.1016/j.jnutbio.2014.06.004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retinopathy in a novel model of metabolic syndrome and type 2 diabetes: New insight on the inflammatory paradigm2014

    • Author(s)
      Noda K, Nakao S, Zandi S, Sun D, Hayes KC, Hafezi-Moghadam A
    • Journal Title

      FASEB J

      Volume: 28 Issue: 5 Pages: 2038-2046

    • DOI

      10.1096/fj.12-215715

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 糖尿病網膜症における炎症と酸化ストレスの関与2014

    • Author(s)
      野田航介
    • Journal Title

      日本の眼科

      Volume: 85 Pages: 142-145

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Blockade for vascular adhesion protein-1 suppresses pathological neovascularization in oxygen-induced retinopathy.2013

    • Author(s)
      Yoshikawa N, Noda K, Ozawa Y, Mashima Y, Ishida S.
    • Journal Title

      Acta Ophthalmologica

      Volume: 91 Pages: 409-410

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Soluble vascular adhesion protein-1 accumulates in proliferative diabetic retinopathy2012

    • Author(s)
      Murata M, Noda K, Fukuhara J, Kanda A, Kase S, Saito W, Ozawa Y, Mochizuki S, Kimura S, Mashima Y, Okada Y, Ishida S.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 Pages: 4055-4062

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Leukocyte Adhesion Molecules in Diabetic Retinopathy2011

    • Author(s)
      Noda K, Nakao S, Ishida S, Ishibashi T
    • Journal Title

      J Ophthalmol. J Ophthalmol

      Volume: 2012 ; 2012 : 279037 Pages: 279037-279037

    • DOI

      10.1155/2012/279037

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 増殖糖尿病網膜症における硝子体中VEGF-B濃度の検討2015

    • Author(s)
      木下哲志、野田航介、田川義晃、石塚タンエルダル、稲福沙織、董 陽子、齋藤 航、神田敦宏、石田 晋
    • Organizer
      第20回日本糖尿病眼学会総会
    • Place of Presentation
      ソラシティカンファレンスセンター(東京都千代田区)
    • Year and Date
      2015-03-06 – 2015-03-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Inflammation and oxidative stress in diabetic retinopathy. Symposium: Molecular mechanisms in diabetic retinopathy2015

    • Author(s)
      Noda K
    • Organizer
      Asia-ARVO 2015
    • Place of Presentation
      パシフィコ横浜(横浜市西区)
    • Year and Date
      2015-02-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Vascular endothelial growth factor increases soluble vascular adhesion protein-1 under high glucose condition2014

    • Author(s)
      Yoshida S, Noda K, Murata M, Kanda A, Ishida S
    • Organizer
      第79回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      北海道大学医学部フラテ会館(札幌市北区)
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Production of soluble vascular adhesion protein-1 by VEGF Stimulation under high glucose condition2014

    • Author(s)
      Noda K, Namba S, Murata M, Kanda A, Ishida S
    • Organizer
      World Ophtalmology Congress 2014 Tokyo
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2014-04-02 – 2014-04-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Shedding of vascular adhesion protein-1 by VEGF stimulation under high glucose condition2013

    • Author(s)
      Namba S, Noda K, Murata M, Kanda A, Ishida S.
    • Organizer
      ARVO (Association for Research in Vision and Ophthalmology) Annual Meeting
    • Place of Presentation
      Washington State Convention Center (Seattle, USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] Vascular endothelial growth factor increases soluble vascular adhesion protein-1 under high glucose condition2013

    • Author(s)
      Namba S, Noda K, Murata M, Kanda A, Ishida S.
    • Organizer
      The 8th Asia Pacific Vitreo-retina Society Congress/52nd Annual Meeting of Japanese Retina and Vitreous Society
    • Place of Presentation
      Nagoya Congress Center(Nagoya)
    • Related Report
      2013 Research-status Report
  • [Presentation] Impact of intravitreal bevacizumab on accumulation of vascular adhesion protein-1 in proliferative diabetic retinopathy2012

    • Author(s)
      Ando R, Noda K, Murata M, Namba S, Kinoshita S, Fukuhara J, Dong Z, Saito W, Kanda A, Ishida S.
    • Organizer
      ARVO(Association for Research in Vision and Ophthalmology) Annual Meeting
    • Place of Presentation
      Broward County convention Center(Fort Lauderdale、米国)
    • Related Report
      2012 Research-status Report
  • [Presentation] 糖負荷時におけるVEGF刺激による可溶型vascular adhesion protein-1産生2012

    • Author(s)
      難波志帆、野田航介、村田美幸、神田敦宏、石田 晋
    • Organizer
      第35回 日本分子生物学会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Research-status Report
  • [Presentation] 増殖糖尿病網膜症におけるVEGF阻害剤の硝子体内VAP-1濃度への影響2012

    • Author(s)
      安藤 亮、野田航介、村田美幸、難波志帆、木下哲志、福原淳一、董 震宇、Anton Lennikov、齋藤 航、神田敦宏、石田 晋.
    • Organizer
      第116回 日本眼科学会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] Recent advances in understanding the molecular mechanism of diabetic retinopathy

    • Author(s)
      Noda K.
    • Organizer
      The 10th Korea-Japan Joint Symposium on Vascular Biology
    • Place of Presentation
      あわぎんホール(徳島)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Soluble vascular adhesion protein-1 in proliferative diabetic retinopathy

    • Author(s)
      Noda K.
    • Organizer
      2012 Seoul National University-Hokkaido University Joint Symposium in Ophthalmology
    • Place of Presentation
      北海道大学医学研究科(札幌)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 酸化ストレスの医学 改訂第2版2014

    • Author(s)
      野田航介
    • Total Pages
      456
    • Publisher
      医学書出版 診断と治療社
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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