Research for new treatments for targeting photoreceptor protection
| Project/Area Number |
24592616
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Hirosaki University |
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Principal Investigator |
NAKAZAWA Mitsuru 弘前大学, 医学(系)研究科(研究院), 教授 (80180272)
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| Co-Investigator(Renkei-kenkyūsha) |
OZAKI Taku 弘前大学, 大学院医学研究科, 特任助教 (70621069)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 網膜色素変性 / カルパイン / 視細胞死 / 点眼療法 / RCSラット / ロドプシン / 神経細胞保護 / 神経細胞死 / 網膜変性疾患 / 国際情報交換 / 網膜疾患 / 視細胞変性 / アポトーシス |
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| Outline of Final Research Achievements |
Retinitis pigmentosa is a group of hereditary retinal degenerations that are primarily caused by mutations of retina-specific genes. Mutations of retina-specific genes eventually cause photoreceptor death, in which calpains play important roles. Among calpain family, I have clarified that mitochondria-specific calpain-1 activates apoptosis inducing factor and leads to apoptosis. In this study, I synthesized a peptide (10 amino acid fragment) that specifically inhibit mitochondrial calpain -1 and clarified that the peptide effectively suppressed the progression of photoreceptor apoptosis by instillation to retinitis pigments model rats as eye drop.
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Report
(4 results)
Research Products
(25 results)
