| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Retinitis pigmentosa is a group of hereditary retinal degenerations that are primarily caused by mutations of retina-specific genes. Mutations of retina-specific genes eventually cause photoreceptor death, in which calpains play important roles. Among calpain family, I have clarified that mitochondria-specific calpain-1 activates apoptosis inducing factor and leads to apoptosis. In this study, I synthesized a peptide (10 amino acid fragment) that specifically inhibit mitochondrial calpain -1 and clarified that the peptide effectively suppressed the progression of photoreceptor apoptosis by instillation to retinitis pigments model rats as eye drop.
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