| Project/Area Number |
24592617
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
GOTO Sakiko 山形大学, 医学部眼科学, 医員 (40444038)
ABE Sachi 山形大学, 医学部眼科学, 助教 (90550658)
NARUMI Mari 山形大学, 医学部眼科学, 医員 (00613069)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 糖尿病網膜症 / 炎天機転 / 樹状細胞 / サイトカイン / 共培養 / 硝子体由来細胞 / ステロイド薬 / 臨床研究 / 炎症機転 / ヒアルロナン / 硝子体糖濃度 / ぶた硝子体細胞 / 網膜硝子体疾患 / 炎症 / 糖尿病黄斑浮腫 / ステロイド / 抗VEGF薬 |
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| Outline of Final Research Achievements |
The molecular pathogenesis of diabetic retinopathy was investigated based on the inflammatory processes. The inflammatory processes included the interaction among dendritic cells, vitreo-retinal cells and vascular cells, and the inflammatory processes were regulated by inflammatory cytokines including VEGF, TNF-α and others. According to the results of this research, the effects of an anti-inflammatory agent, steroid, on diabetic retinopathy were investigated, and topical steroid treatment was shown to be effective to treat diabetic retinopathy clinically.
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