The screening of the inhibitory factor for neovascularization in lens and the establishment of new concept for the pathology of neovascular glaucoma
| Project/Area Number |
24592620
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | University of Fukui |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
INATANI Masaru 福井大学, 医学部, 教授 (40335245)
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 血管新生 / 水晶体 / クリスタリン / 糖尿病網膜症 / 血管新生抑制 / αクリスタリンB |
|---|
| Outline of Final Research Achievements |
The result of western blotting and real time PCR indicates that α-crystallins may be derive from not only hyalocyte but leak or secretion from lens. Our study showed inhibitory effect of αB-crystalline on cell proliferation statistically and the effect were intensified with αA-crystalline in a synergistic manner. The disruption of homeostasis in eyes subsequent to lens removal causes the lower expression of α-crytallins and imbalance of crystalline and VEGF may induce the formation of abnormal capillary to vitreous cavity.
|
Report
(5 results)
Research Products
(5 results)
