The screening of the inhibitory factor for neovascularization in lens and the establishment of new concept for the pathology of neovascular glaucoma

• Project/Area Number: 24592620
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: University of Fukui
• Principal Investigator: Takamura Yoshihiro 福井大学, 医学部, 准教授 (00283193)
• Co-Investigator(Kenkyū-buntansha): INATANI Masaru 福井大学, 医学部, 教授 (40335245)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 血管新生 / 水晶体 / クリスタリン / 糖尿病網膜症 / 血管新生抑制 / αクリスタリンB

Outline of Final Research Achievements

The result of western blotting and real time PCR indicates that α-crystallins may be derive from not only hyalocyte but leak or secretion from lens. Our study showed inhibitory effect of αB-crystalline on cell proliferation statistically and the effect were intensified with αA-crystalline in a synergistic manner. The disruption of homeostasis in eyes subsequent to lens removal causes the lower expression of α-crytallins and imbalance of crystalline and VEGF may induce the formation of abnormal capillary to vitreous cavity.

Research Products

• [Journal Article] Vitreous and Aqueous Concentrations of Brimonidine Following Topical Application of Brimonidine Tartrate 0.1% Ophthalmic Solution in Humans. (2015)
  • Author(s): Takamura Y, Tomomatsu T, Matsumura T, Takihara Y, Kozai S, Arimura S, Yokota S, Inatani M.
  • Journal Title: J Ocul Pharmacol Ther. Volume: In press
  • Peer Reviewed
• [Journal Article] Determinants of anterior chamber angle narrowing after mydriasis in the patients with cataract. (2015)
  • Author(s): Arimura S
  • Journal Title: Graefes Archives Clinical Experimental Ophthalmology Volume: 253 Issue: 2 Pages: 307-312
  • DOI: 10.1007/s00417-014-2817-x
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Changes of Matrix Metalloproteinases in Diabetes Patients’ Tears after Vitrectomy and the Relationship with Corneal Epithelial Disorder (2015)
  • Author(s): Takehiro Matsumura, Yoshihiro Takamura, Takeshi Tomomatsu, Shogo Arimura, Makoto Gozawa, Yuji Takihara, Masaru Inatani
  • Journal Title: Invest Ophthalmol Vis Sci Volume: In press
  • Peer Reviewed
• [Journal Article] Comparative study of combined bevacizumab/targeted photocoagulation vs bevacizumab alone for macular edema in ischemic branch retinal vein occlusions. (2015)
  • Author(s): Yoko Tomomatsu, Takeshi Tomomatsu, Yoshihiro Takamura, Takehiro Matsumura, Yuji Takihara, Masaru Inatani.
  • Journal Title: Acta ophthalmolgica Volume: In press
  • Peer Reviewed
• [Presentation] 血管新生抑制因子Tenomodulinの白内障における発現 (2014)
  • Author(s): 友松威
  • Organizer: 第53回白内障学会総会
  • Place of Presentation: TKPガーデンシティ品川
  • Year and Date: 2014-09-27 – 2014-09-28