Building an prediction model for the fellow eye involvement of age-relate macular degeneration using genome information, and physiological or morphological feature of photo receptor

• Project/Area Number: 24592626
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: TAMURA HIROSHI 京都大学, 医学(系)研究科(研究院), 准教授 (40418760)
• Co-Investigator(Kenkyū-buntansha): OOTO Soutaro 京都大学, 医学研究科, 講師 (10511850) ; OGINO Ken 京都大学, 医学研究科, 助教 (70622629)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 加齢黄斑変性 / 予測モデル / 2眼目 / ゲノム / 国際情報交換 / 国際情報交換（アメリカ）

Outline of Final Research Achievements

In the research, we aimed to build a prediction model for the fellow eye involvement of age-relate macular degeneration using genome information, and physiological or morphological feature of photo receptor.
Throughout the 3-year research period, we corrected the general predicting factors, genotypes associated with AMD and images obtained with adaptive optics scanning laser ophthalmoscope. We analyzed the data comprehensively to make the prediction model.

Research Products

• [Journal Article] One-year result of aflibercept treatment in age-related macular degeneration and predictive factors for visual outcome. (2015)
  • Author(s): Oishi A, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Nakanishi H, Ueda-Arakawa N, Miyake M, Akagi-Kurashige Y, Hata M, Yoshikawa M, Kuroda Y, Takahashi A, Yoshimura N.
  • Journal Title: Am J Ophthalmol. Volume: 158 Issue: 5 Pages: 853-60
  • DOI: 10.1016/j.ajo.2015.01.018
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evaluating the Effect of Japan's 2004 Postgraduate Training Program on the Spatial Distribution of Physicians. (2015)
  • Author(s): Sakai R, Tamura H, Goto R, Kawachi I.
  • Journal Title: Human Resources for Health Volume: 13 Issue: 1 Pages: 5-5
  • DOI: 10.1186/1478-4491-13-5
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of Intravitreal Injection of Aflibercept in Neovascular Age-Related Macular Degeneration with or without Choroidal Vascular Hyperpermeability. (2014)
  • Author(s): Hata M, Oishi A, Tsujikawa A, Yamashiro K, Miyake M, Ooto S, Tamura H, Nakanishi H, Takahashi A, Yoshikawa M, Yoshimura N.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 55 Issue: 12 Pages: 7874-80
  • DOI: 10.1167/iovs.14-14610
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Assessment of vision-related quality of life among patients with cataracts and the outcomes of cataract surgery using a newly developed visual function questionnaire: the VFQ-J11. (2014)
  • Author(s): Hiratsuka Y, Yamada M, Akune Y, Murakami A, Okada AA, Yamashita H, Ohashi Y, Yamagishi N, Tamura H, Fukuhara S, Takura T.
  • Journal Title: Jpn J Ophthalmol. Volume: 58 Issue: 5 Pages: 415-422
  • DOI: 10.1007/s10384-014-0335-3
  • Peer Reviewed
• [Journal Article] Choroidal Neovascularization in Eyes with Choroidal Vascular Hyperpermeability. (2014)
  • Author(s): Miyake M, Tsujikawa A, Yamashiro K, Ooto S, Oishi A, Nakata I, Tamura H, Matsuda F, Yoshimura N.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 55 Issue: 5 Pages: 3223-30
  • DOI: 10.1167/iovs.14-14059
  • Peer Reviewed
• [Journal Article] Macular Choroidal Thickness and Volume of Eyes with Reticular Pseudodrusen Using Swept-Source Optical Coherence Tomography. (2014)
  • Author(s): Ueda-Arakawa N, Ooto S, Ellabban AA, Takahashi A, Oishi A, Tamura H, Yamashiro K, Tsujikawa A, Yoshimura N.
  • Journal Title: Am J Ophthalmol Volume: 157 Issue: 5 Pages: 994-1004
  • DOI: 10.1016/j.ajo.2014.01.018
  • Peer Reviewed
• [Journal Article] Calcification of the placenta in a woman with pseudoxanthoma elasticum with a mutation of the ABCC6 gene. (2014)
  • Author(s): Tanioka M, Utani A, Tamura H, Yoshimura N, Kashiwagi N, Kondo E, Konishi I, Miyachi Y.
  • Journal Title: The Journal of Dermatology. Volume: 41 Issue: 2 Pages: 189-91
  • DOI: 10.1111/1346-8138.12360
  • Peer Reviewed
• [Journal Article] The impact of Japan's 2004 postgraduate training program on intra-prefectural distribution of pediatricians in Japan. (2013)
  • Author(s): Sakai R, Wang W, Yamaguchi N, Tamura H, Goto R, Kawachi I
  • Journal Title: PLoS ONE Volume: 8 Issue: 10 Pages: e77045-e77045
  • DOI: 10.1371/journal.pone.0077045
  • Peer Reviewed
• [Journal Article] Reduction of Retinal Sensitivity in Eyes With Reticular Pseudodrusen (2013)
  • Author(s): Ooto S, Ellabban AA, Ueda-Arakawa N, Oishi A, Tamura H, Yamashiro K., Tsujikawa A, Yoshimura N.
  • Journal Title: Am J Ophthalmol Volume: 156 Issue: 6 Pages: 1184-1191
  • DOI: 10.1016/j.ajo.2013.06.036
  • Peer Reviewed
• [Journal Article] Economic Estimation of Nursing Services under the Diagnostic Procedure Combination/Per- Diem Payment System. (2013)
  • Author(s): Akiyama T, Akiyama N, Hayashida K, Tamura H.
  • Journal Title: J Nurs Care Volume: 8
  • DOI: 10.4172/2167-1168.s5-008
  • Peer Reviewed
• [Journal Article] Cost-utility analysis of cataract surgery in Japan: a probabilistic Markov modeling study. (2013)
  • Author(s): Hiratsuka Y, Akune Y, Yamada M, Eye Care Comparative Effectiveness Research Team (ECCERT).
  • Journal Title: Jpn J Ophthalmol Volume: 27 Issue: 4 Pages: 391-401
  • DOI: 10.1007/s10384-013-0238-8
  • Peer Reviewed
• [Journal Article] The Time Course Changes of Choroidal Neovascularization in Angioid Streaks (2013)
  • Author(s): Nakagawa S. Yamashiro K. Tsujikawa A. Otani A, Tamura H, Ooto S, Yoshimura N.
  • Journal Title: Retina Volume: 33 Issue: 4 Pages: 825-833
  • DOI: 10.1097/iae.0b013e31826b0bbe
  • Peer Reviewed
• [Journal Article] Long-term effect of intravitreal injection of anti-VEGF agent for visual acuity and chorioretinal atrophy progression in myopic choroidal neovascularization (2013)
  • Author(s): Oishi A, Yamashiro K, Tsujikawa A, Ooto S, Tamura H, Nakata I, Miyake M, Yoshimura N
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 251 Issue: 1 Pages: 1-7
  • DOI: 10.1007/s00417-012-2022-8
  • NAID: 120005241384
  • Peer Reviewed
• [Journal Article] Cost-utility analysis of cataract surgery in Japan: a probabilistic Markov modeling study. (2013)
  • Author(s): Eye Care Comparative Effectiveness Research Team (ECCERT).
  • Journal Title: Jpn J Ophthalmol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Relationship between retinal morphological findings and visual function in age-related macular degeneration. (2012)
  • Author(s): Akagi-Kurashige Y, Tsujikawa A, Oishi A, Ooto S, Yamashiro K, Tamura H, Nakata I, Ueda-Arakawa N, Yoshimura N.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 250 Pages: 129-36
  • NAID: 120004873995
  • Peer Reviewed
• [Journal Article] Factors Associated with the Response of Age-related Macular Degeneration to Intravitreal Ranibizumab Treatment (2012)
  • Author(s): Yamashiro K, Tomita K, Tsujikawa A, Nakata I, Akagi-Kurashige Y, Miyake M, Ooto S, Tamura H, Yoshimura N.
  • Journal Title: Am J Ophthalmol Volume: 154 Issue: 1 Pages: 125-36
  • DOI: 10.1016/j.ajo.2012.01.010
  • Peer Reviewed
• [Journal Article] Retinal Structural Alterations and Macular Sensitivity in Idiopathic Macular Telangiectasia Type (2012)
  • Author(s): Takayama K, Ooto S, Tamura H, Yamashiro K, Otani A, Tsujikawa A, Yoshimura N.
  • Journal Title: Retina Volume: 32 Pages: 1973-80
  • Peer Reviewed
• [Journal Article] Association of ARMS2 Genotype with Bilateral Involvement of Exudative Age-Related Macular Degeneration (2012)
  • Author(s): Tamura H, Tsujikawa A, Yamashiro K, Akagi-Kurashige Y, Nakata I, Nakanishi H, Hayashi H, Ooto S, Otani A, Yoshimura N.
  • Journal Title: Am J Ophthalmol Volume: 154 Issue: 3 Pages: 542-548
  • DOI: 10.1016/j.ajo.2012.03.042
  • NAID: 120004874011
  • Peer Reviewed
• [Journal Article] Visual prognosis of eyes with submacular hemorrhage associated with exudative age-related macular degeneration. (2012)
  • Author(s): Ueda-Arakawa N, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Yoshimura N.
  • Journal Title: Jpn J Ophthalmol Volume: 56 Issue: 6 Pages: 589-98
  • DOI: 10.1007/s10384-012-0191-y
  • NAID: 10031126907
  • Peer Reviewed
• [Journal Article] 弾性線維性仮性黄色腫診断基準 2012 (2012)
  • Author(s): 厚生労働省難治性疾患克服研究事業「弾性線維性仮性黄色腫の病態把握ならびに診断基準作成」班:宇谷厚志 北岡隆 前村浩二 荻朋男 谷岡未樹 田村寛 山本洋介 築城英子 服部友保
  • Journal Title: 日眼会誌 Volume: 116 Pages: 1156-1157
  • NAID: 130004708894
  • Peer Reviewed
• [Journal Article] 弾性線維性仮性黄色腫診断基準 2012 (2012)
  • Author(s): 厚生労働省難治性疾患克服研究事業「弾性線維性仮性黄色腫の病態把握ならびに診断基準作成」班：宇谷厚志 北岡隆 前村浩二 荻朋男 谷岡未樹 田村寛 山本洋介 築城英子 服部友保
  • Journal Title: 日皮会誌 Volume: 122 Pages: 2303-2304
  • NAID: 130004708894
  • Peer Reviewed
• [Presentation] Factors Associated With Retreatment After Ranibizumab Loading Treatment for Exudative AMD. (2014)
  • Author(s): Yamashiro K, Tsujikawa A, Ooto S, Tamura H, Oishi A, Nakanishi H, Miyake M, Yoshikawa M, Yoshimura N.
  • Organizer: American Academy of Ophthalmology 2014
  • Place of Presentation: Chicago
  • Year and Date: 2014-10-20
• [Presentation] Factors Associated With the Required Interval of Ranibizumab Treatment for Exudative AMD. (2014)
  • Author(s): Kuroda Y, Miyake M, Tsujikawa A, Ooto S, Tamura H, Oishi A, Nakanishi H, Yoshimura N.
  • Organizer: American Academy of Ophthalmology 2014
  • Place of Presentation: Chicago
  • Year and Date: 2014-10-20
• [Presentation] Factor for Visual Outcomes Two-Years after Intravitreal ranibizumab for Myopic Choroidal Neovascularization. (2014)
  • Author(s): Nakanishi H, Tsujikawa A, Yamashiro K, Oishi A, Ooto S, Tamura H, Yoshimura N.
  • Organizer: Association for Research in Vision and Ophthalmology 2014
  • Place of Presentation: Orland
  • Year and Date: 2014-05-07
• [Presentation] Association of Age-related Macular Degeneration (AMD) Susceptible Genes with Second Eye Involvement of AMD. (2014)
  • Author(s): Miyake M, Yamashiro K, Kumagai K, Tamura H, Yoshikawa M, Nakata I, Nakanishi H, Gotoh N, Tsujikawa A, Yoshimura N.
  • Organizer: Association for Research in Vision and Ophthalmology 2014
  • Place of Presentation: Orland
  • Year and Date: 2014-05-07
• [Presentation] A case report of operation improvement in a significant academic hospital in Japan. (2013)
  • Author(s): Tamura H
  • Organizer: Koc University – Kyoto University International Symposium on “New Frontiers in Health Sciences &Technologies”
  • Place of Presentation: Kyoto
  • Invited
• [Presentation] Identification of ABCC6 gene mutations in the Japanese patients with pseudoxanthoma elasticum (PXE). (2013)
  • Author(s): Iwanaga A, Yozaki M, Yagi Y, Maemura K, Tsuiki E, Kitaoka T, Tanioka M, Tamura H, Yamamoto Y, Hattori T, Isogai Z, Ogi T, Yoshiura K, Utani A.
  • Organizer: The 6th joint meeting of the European Society for Dermatological Research (ESDR), Japanese Society for Investigative Dermatology (JSID), Society for Investigative Dermatology (SID) 2013
  • Place of Presentation: Edinburgh, Scotland
• [Presentation] 白内障早期診断のためのコントラスト感度評価システムの構築 (2013)
  • Author(s): 桜井理紗, 竹村匡正, 田村 寛, 黒田知宏, 堀尾裕幸, 山下和彦.
  • Organizer: 第40回Mテクノロジー学会大会
  • Place of Presentation: 神戸
• [Presentation] 眼科医療における費用対効果 加齢黄斑変性診療の費用対効果分析 (2013)
  • Author(s): 田村 寛
  • Organizer: 第117回日本眼科学会総会
  • Place of Presentation: 東京
  • Invited
• [Presentation] シンポジウム「眼科医療における費用対効果」 加齢黄斑変性診療の費用対効果分析 (2013)
  • Author(s): 田村 寛
  • Organizer: 第117回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] ポリープ状脈絡膜血管症に対するranibizumab投与の黄斑部局所網膜電図モニタリング(12ヵ月経過)。
  • Author(s): 荻野 顕, 辻川 明孝, 山城 健児, 大音 壮太郎, 田村 寛, 大石 明生, 仲田 勇夫, 赤木 由美子, 三宅 正裕, 吉村 長久.
  • Organizer: 京都眼科学会
  • Place of Presentation: 京都
• [Book] これからはじめる周術期口腔機能管理マニュアル (2013)
  • Author(s): 邑田悟、田村 寛.
  • Total Pages: 111
  • Publisher: 永松出版
• [Book] 「平成２４年度診療報酬改定の概要」（4-7）「医科歯科併設病院の経営に与える影響」（11-12）：これからはじめる周術期口腔機能管理マニュアル (2013)
  • Author(s): 邑田悟・田村寛
  • Publisher: 永末書店
• [Book] 弾性線維性仮性黄色腫診断基準作成：眼科領域 (2012)
  • Author(s): 田村寛、北岡隆、都築英子、宇谷厚志
  • Publisher: 厚生労働科学研究（難治性疾患克服研究事業）「弾性線維性仮性黄色腫の病態把握ならびに診断基準作成」平成23年度総括・分担研究報告書