Building an prediction model for the fellow eye involvement of age-relate macular degeneration using genome information, and physiological or morphological feature of photo receptor
| Project/Area Number |
24592626
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto University |
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Principal Investigator |
TAMURA HIROSHI 京都大学, 医学(系)研究科(研究院), 准教授 (40418760)
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| Co-Investigator(Kenkyū-buntansha) |
OOTO Soutaro 京都大学, 医学研究科, 講師 (10511850)
OGINO Ken 京都大学, 医学研究科, 助教 (70622629)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 加齢黄斑変性 / 予測モデル / 2眼目 / ゲノム / 国際情報交換 / 国際情報交換（アメリカ） |
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| Outline of Final Research Achievements |
In the research, we aimed to build a prediction model for the fellow eye involvement of age-relate macular degeneration using genome information, and physiological or morphological feature of photo receptor.
Throughout the 3-year research period, we corrected the general predicting factors, genotypes associated with AMD and images obtained with adaptive optics scanning laser ophthalmoscope. We analyzed the data comprehensively to make the prediction model.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] One-year result of aflibercept treatment in age-related macular degeneration and predictive factors for visual outcome.2015
Author(s)
Oishi A, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Nakanishi H, Ueda-Arakawa N, Miyake M, Akagi-Kurashige Y, Hata M, Yoshikawa M, Kuroda Y, Takahashi A, Yoshimura N.
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Journal Title
Am J Ophthalmol.
Volume: 158
Issue: 5
Pages: 853-60
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Efficacy of Intravitreal Injection of Aflibercept in Neovascular Age-Related Macular Degeneration with or without Choroidal Vascular Hyperpermeability.2014
Author(s)
Hata M, Oishi A, Tsujikawa A, Yamashiro K, Miyake M, Ooto S, Tamura H, Nakanishi H, Takahashi A, Yoshikawa M, Yoshimura N.
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 55
Issue: 12
Pages: 7874-80
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Assessment of vision-related quality of life among patients with cataracts and the outcomes of cataract surgery using a newly developed visual function questionnaire: the VFQ-J11.2014
Author(s)
Hiratsuka Y, Yamada M, Akune Y, Murakami A, Okada AA, Yamashita H, Ohashi Y, Yamagishi N, Tamura H, Fukuhara S, Takura T.
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Journal Title
Jpn J Ophthalmol.
Volume: 58
Issue: 5
Pages: 415-422
DOI
Related Report
Peer Reviewed
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[Presentation] Identification of ABCC6 gene mutations in the Japanese patients with pseudoxanthoma elasticum (PXE).2013
Author(s)
Iwanaga A, Yozaki M, Yagi Y, Maemura K, Tsuiki E, Kitaoka T, Tanioka M, Tamura H, Yamamoto Y, Hattori T, Isogai Z, Ogi T, Yoshiura K, Utani A.
Organizer
The 6th joint meeting of the European Society for Dermatological Research (ESDR), Japanese Society for Investigative Dermatology (JSID), Society for Investigative Dermatology (SID) 2013
Place of Presentation
Edinburgh, Scotland
Related Report
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