| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Retinal pigment epithelial cells (RPE) has a variety of physiological functions to maintain homeostasis of the retina. In the age-related macular degeneration, homeostasis of the retina collapses by decreased function of the RPE associated with aging, and leads to visual disturbance. In this study, for the ARPE-19 and human iPS-derived RPE, we induced senescence of RPE by chronic oxidative stress, and revealed a change in the functions of the RPE associated with aging. In addition, using models of inflammation to induce epithelial-mesenchymal transition in the RPE, we revealed that the activation of AMPK inhibits epithelial-mesenchymal transformation in the RPE.
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