Inhibition of RPE senescence by AMPK activation
| Project/Area Number |
24592630
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOSAKA Jun 国際医療福祉大学, 基礎医学研究センター, 教授 (40243216)
YONEZAWA Tomoko 岡山大学, 医歯(薬)学総合研究科, 助教 (30304299)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 加齢黄斑変性 / 網膜色素上皮細胞 / AMPK |
|---|
| Outline of Final Research Achievements |
Retinal pigment epithelial cells (RPE) has a variety of physiological functions to maintain homeostasis of the retina. In the age-related macular degeneration, homeostasis of the retina collapses by decreased function of the RPE associated with aging, and leads to visual disturbance. In this study, for the ARPE-19 and human iPS-derived RPE, we induced senescence of RPE by chronic oxidative stress, and revealed a change in the functions of the RPE associated with aging. In addition, using models of inflammation to induce epithelial-mesenchymal transition in the RPE, we revealed that the activation of AMPK inhibits epithelial-mesenchymal transformation in the RPE.
|
Report
(4 results)
Research Products
(3 results)
