| Project/Area Number |
24592631
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nagasaki University |
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Principal Investigator |
SUZUMA Kiyoshi 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (80335265)
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| Co-Investigator(Kenkyū-buntansha) |
TSUIKI Eiko 長崎大学, 医歯薬学総合研究科(医学系), 講師 (30363493)
FUJIKAWA Azusa 長崎大学, 病院(医学系), 講師 (60363503)
MATSUMOTO Makiko 長崎大学, 医歯薬学総合研究科(医学系), 助教 (70437903)
KITAOKA Takashi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80234235)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | VEGF / 糖尿病網膜症 / エリスロポエチン / コハク酸 / インクレチン / exendin4 / 血管透過性 / 毛様体 / 神経節細胞 / iPS細胞 / 血管再生 |
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| Outline of Final Research Achievements |
Diabetic retinopathy is the leading cause of new onset blindness among working age individuals. Vascular endothelial growth factor (VEGF) has been strongly implicated as a primary mediator of ocular complications in diabetes and age-related macular degeneration. We reported that mechanical stretch induced expression of VEGF and its receptors in retinal vascular cells and demonstrated that retinal expression of VEGF and VEGF-R2 was increased during hypertension in vivo. It has recently been demonstrated that G protein-coupled receptor 91 (GPR91: a succinate receptor) plays a major role in both vasculature development and retinal angiogenesis. Recently, we have reported increases of succinate in vitreous from proliferative diabetic retinopathy patients and the signaling pathways involved in hypertension-dependent succinate release.
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