Regeneration of retinal vasculature in diabetic retinopathy with growth factors and signal transduction
| Project/Area Number |
24592631
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nagasaki University |
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Principal Investigator |
SUZUMA Kiyoshi 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (80335265)
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| Co-Investigator(Kenkyū-buntansha) |
TSUIKI Eiko 長崎大学, 医歯薬学総合研究科(医学系), 講師 (30363493)
FUJIKAWA Azusa 長崎大学, 病院(医学系), 講師 (60363503)
MATSUMOTO Makiko 長崎大学, 医歯薬学総合研究科(医学系), 助教 (70437903)
KITAOKA Takashi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80234235)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | VEGF / 糖尿病網膜症 / エリスロポエチン / コハク酸 / インクレチン / exendin4 / 血管透過性 / 毛様体 / 神経節細胞 / iPS細胞 / 血管再生 |
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| Outline of Final Research Achievements |
Diabetic retinopathy is the leading cause of new onset blindness among working age individuals. Vascular endothelial growth factor (VEGF) has been strongly implicated as a primary mediator of ocular complications in diabetes and age-related macular degeneration. We reported that mechanical stretch induced expression of VEGF and its receptors in retinal vascular cells and demonstrated that retinal expression of VEGF and VEGF-R2 was increased during hypertension in vivo. It has recently been demonstrated that G protein-coupled receptor 91 (GPR91: a succinate receptor) plays a major role in both vasculature development and retinal angiogenesis. Recently, we have reported increases of succinate in vitreous from proliferative diabetic retinopathy patients and the signaling pathways involved in hypertension-dependent succinate release.
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Report
(5 results)
Research Products
(32 results)
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[Journal Article] Optimized Culture System to Induce Neurite Outgrowth From Retinal Ganglion Cells in Three-Dimensional Retinal Aggregates Differentiated From Mouse and Human Embryonic Stem Cells.2016
Author(s)
Maekawa Y, Onishi A, Matsushita K, Koide N, Mandai M, Suzuma K, Kitaoka T, Kuwahara A, Ozone C, Nakano T, Eiraku M, Takahashi M
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Journal Title
Curr Eye Res
Volume: 19
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Systemic factors influence the prognosis of diabetic Ocular gene delivery systems using ternary complexes of plasmid DNA, polyethylenimine, and anionic polymers.2013
Author(s)
Kurosaki T, Uematsu M, Shimoda K, Suzuma K, Nakai M, Nakamura T, Kitahara T, Kitaoka T, Sasaki H
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Journal Title
Biol Pharm Bull
Volume: 36
Pages: 96-101
Related Report
Peer Reviewed
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[Presentation] NEURITE OUTGROWTH FROM RETINAL GANGLION CELLS IN SELF-ORGANIZING MOUSE AND HUMAN RETINAL TISSUES DIFFERENTIATED FROM EMBRYONIC STEM CELLS.2015
Author(s)
Maekawa Y, Onishi A, Matsushita K, Koide N, Mandai M, Suzuma K, Kitaoka T, Kuwahara A, Ozone C, Nakano T, Eiraku M, Takahashi M
Organizer
ISSCR 2015 Annual Meeting
Place of Presentation
Stockholmsmässan Exhibition and Convention Center（Ｓｔｏｃｋｈｏｌｍ・Ｓｗｅｄｅｎ）
Year and Date
2015-06-24
Related Report
Int'l Joint Research
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