Candidate gene analysis of well-known genes in primary open-angle glaucoma patients utilizing custom-made gene chip

• Project/Area Number: 24592636
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: MORI Kazuhiko 京都府立医科大学, 医学(系)研究科(研究院), 講師 (40252001)
• Co-Investigator(Kenkyū-buntansha): MATSUDA Akira 順天堂大学, 医学(系)研究科(研究院), 准教授 (00312348) ; IKEDA Yoko 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (00433243) ; TASHIRO Kei 京都府立医科大学, 医学(系)研究科(研究院), 教授 (10263097) ; KINOSHITA Shigeru 京都府立医科大学, 医学(系)研究科(研究院), 教授 (30116024) ; UENO Morio 京都府立医科大学, 医学(系)研究科(研究院), 助教 (40426531) ; NAKANO Masakazu 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (70381944)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 眼遺伝学

Outline of Final Research Achievements

In this study, we performed a case-control analysis in 609 single nucleotide polymorphisms (SNPs), which are selected from our original clinical database collected for more than 15 years and from our genomic information of more than 4000 cases, between primary open-angle glaucoma (POAG) patients and normal controls, and found several new SNPs that related to Japanese POAG patients.

Research Products

• [Journal Article] Morphological analysis of age-related iridocorneal angle changes in normal and glaucomatous cases using anterior segment optical coherence tomography. (2014)
  • Author(s): 1.Maruyama Y, Mori K**, Ikeda Y, Ueno M, Kinoshita S.
  • Journal Title: Clin Ophthalmol Volume: 8 Pages: 113-118
  • Peer Reviewed / Open Access
• [Journal Article] Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population (2014)
  • Author(s): 5.Nakano M, Ikeda Y, Tokuda Y, Fuwa M, Ueno M, Imai K, Sato R, Omi N, Adachi H, Kageyama M, Mori K, Kinoshita S, Tashiro K
  • Journal Title: Sci Rep Volume: 4 Pages: 5340-5340
  • Peer Reviewed
• [Journal Article] Morphological analysis of age-related iridocorneal angle changes in normal and glaucomatous cases using anterior segment optical coherence tomography. (2014)
  • Author(s): Maruyama Y, Mori K, Ikeda Y, Ueno M, Kinoshita S.
  • Journal Title: Clinical Ophthalmology Volume: 8 Pages: 113-118
  • DOI: 10.2147/opth.s52370
  • Peer Reviewed
• [Journal Article] Changes in visual acuity and intra-ocular pressure following bleb-related infection: the Japan Glaucoma Society Survey of Bleb-related Infection Report 2 (2013)
  • Author(s): Yamamoto T, Kuwayama Y, Nomura E, Tanihara H, Mori K; Japan Glaucoma Society Survey of Bleb-related Infection
  • Journal Title: Acta Ophthalmologica Volume: 91 Issue: 6 Pages: 420-426
  • DOI: 10.1111/aos.12079
  • Peer Reviewed
• [Journal Article] Common variants in CDKN2B-AS1 associated with optic-nerve vulnerability of glaucoma identified by genome-wide association studies in Japanese (2012)
  • Author(s): Nakano M, Ikeda Y, Mori K, Kinoshita S, Tashiro K, 他
  • Journal Title: PLoS One Peer-Reviewed papers Volume: 7(3) Issue: 3 Pages: e33389-e33389
  • DOI: 10.1371/journal.pone.0033389
  • Peer Reviewed
• [Presentation] Genetics in normal tension glaucoma (2015)
  • Author(s): Kazuhiko Mori
  • Organizer: Asia ARVO
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2015-02-17
• [Presentation] Genome-wide association study of exfoliation syndrome/exfoliation glaucoma in a Japanese population. (2014)
  • Author(s): Nakano M, Ikeda Y, Tokuda Y, Adachi H, Ueno M, Imai K, Sato R, Omi N, Mori K, Kinoshita S, Tashiro K
  • Organizer: 64th Annual Meeting of the American Society of Human Genetics (ASHG)
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2014-10-18 – 2014-10-22
• [Presentation] Association analysis between CDKN2B-AS1 genotype and quantitative traits of primary open-angle glaucoma (2014)
  • Author(s): Ikeda Y, Mori K, Ueno M, Nakano M, Tokuda Y, Omi N, Sato R, Yoshii K, Tashiro K, Kinoshita S
  • Organizer: 2014 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2014-05-04 – 2014-05-08
• [Presentation] Comparison of the systemic risk factors, including body mass index, between primary open-angle glaucoma and normal tension glaucoma. (2014)
  • Author(s): Sannohe C, Ikeda Y, Mori K, Yamada H, Tsuzaki S, Hasegawa S, Ueno M, Nakano M, Yoshii K, Kinoshita S
  • Organizer: 2014 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2014-05-04 – 2014-05-08
• [Presentation] Analysis of hematological and biochemical data in normal tension glaucoma patients (2014)
  • Author(s): Ueno M, Ikeda Y, Mori K, Tashiro K, Kinoshita S.
  • Organizer: World Ophthalmology Congress
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2014-04-02 – 2014-04-06
• [Presentation] Analysis of ophthalmic clinical data association for CDKN2BAS-1 genotype in normal subjects. (2013)
  • Author(s): 6. Ikeda Y, Mori K, M Ueno M, Nakano M, Tokuda Y, Omi N, Sato R, Yoshii K, Tashiro K, Kinoshita S
  • Organizer: 5th World Glaucoma Congress
  • Place of Presentation: Vancouver, Canada
• [Presentation] Evaluation of the age-related speed of anterior chamber reduction by 3D Scheimpflug camera in Japanese normal subjects (2013)
  • Author(s): 10. Ikeda Y, Mori K, Ueno M, Yoshikawa H, Maruyama Y, Yoshii K, Kinoshita S
  • Organizer: American Academy of Ophthalmology
  • Place of Presentation: New Orleans, Louisiana, USA
• [Presentation] Common genetic variants of primary open-angle glaucoma in Japanese population (2012)
  • Author(s): Nakano M, Ikeda Y, Tokuda Y, Fuwa M, Omi N, Adachi H, Ueno M, Mori K, Kinoshita S, and Tashiro K
  • Organizer: 62nd Annual Meeting of the American Society of Human Genetics
  • Place of Presentation: San Francisco, CA, USA
• [Presentation] Association of risk alleles of glaucoma marker SNPs with morphological characters of the optic disc (2012)
  • Author(s): Ikeda Y, Mori K, Ueno M, Imai K, Nakano M, Fuwa M, Yoshii K, Yagi Y, Tokuda Y, Tashiro K, and Kinoshita S
  • Organizer: 10th Congress of the European Glaucoma Society (EGS)
  • Place of Presentation: Copenhagen, Denmark
• [Presentation] Genome-wide association study on primary open-angle glaucoma with a 1000K gene chip (2012)
  • Author(s): Mori K, Ikeda Y, Ueno M, Imai K, Nakano M, Tokuda Y, Omi N, Adachi H, Tashiro K, and Kinoshita S
  • Organizer: Annual Meeting of the Association for Research in Vision and Ophthalmology
  • Place of Presentation: Fort Lauderdale, FL, USA
• [Presentation] Analysis of Hematological and Biochemical Data in Primary Open‐Angle Glaucoma Patients (2012)
  • Author(s): Maruyama Y, Mori K, Yoshii H, Yoshikawa H, Ikeda Y, Ueno M, Tashiro K, Kinoshita S
  • Organizer: Asia Pacific Glaucoma Congress
  • Place of Presentation: Bali, Indonesia
• [Presentation] Analysis of hematological and biochemical data in normal tension glaucoma patients
  • Author(s): 2. Ueno M, Ikeda Y, Yoshii K, Yoshikawa H, Maruyama Y, Yuko, Mori K, Tashiro K, Kinoshita S
  • Organizer: 2013 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
  • Place of Presentation: Seattle, Washington, USA
• [Presentation] Analysis of ophthalmic clinical data association for CDKN2B-AS1 genotype in normal subjects.
  • Author(s): 4. Ikeda Y, Mori K, Ueno M, Nakano M, Tokuda Y, Omi N, Sato R, Yoshii K, Tashiro K, Kinoshita S
  • Organizer: 2013 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
  • Place of Presentation: Seattle, Washington, USA