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The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa

Research Project

Project/Area Number 24592647
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionKeio University

Principal Investigator

OZAWA Yoko  慶應義塾大学, 医学部, 講師 (90265885)

Research Collaborator TETSU Yoshida  慶應義塾大学, 医学部, 特任助教
WADO Akamatsu  慶應義塾大学, 医学部, 講師 (60338184)
HARUNA Mabuchi  慶應義塾大学, 医学部, 特任研究員 (70465011)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords網膜 / 幹細胞 / iPS / 再生 / 神経保護
Outline of Final Research Achievements

We generated induced pluripotent stem cells (iPSCs) from an RP patient carrying a rhodopsin mutation (E181K). The cells were then subjected to retinal differentiation; the resulting rod photoreceptor cells were labeled with an Nrl promoter-driven enhanced EGFP-carrying adenovirus and purified using flow cytometry after 5 weeks of culture. Using this approach, we found a reduced survival rate in the photoreceptor cells with the E181K mutation, which was correlated with the increased expression of endoplasmic reticulum (ER) stress and apoptotic markers. The use of RP patient-derived iPSCs provided a system that can be used to explore candidate therapeutic approaches.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (65 results)

All 2015 2014 2013 2012 2011

All Journal Article (41 results) (of which Peer Reviewed: 41 results,  Open Access: 12 results,  Acknowledgement Compliant: 8 results) Presentation (24 results) (of which Invited: 8 results)

  • [Journal Article] Clinical and Molecular Characteristics of Childhood-onset Stargardt Disease.2015

    • Author(s)
      Fujinami K, Jana Zernant, Ravinder K Chana, Genevieve A Wright, Tsunoda K, Ozawa Y, Tsubota K, Anthony G Robson, Graham E Holder, Rando Allikmets, Michel Michaelides, FACS; Anthony T Moore.
    • Journal Title

      Ophthalmology.

      Volume: 122 Issue: 2 Pages: 326-334

    • DOI

      10.1016/j.ophtha.2014.08.012

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Wickerhamomyces anomalus Fungal Keratitis Responds to Topical Treatment with Antifungal Micafungin.2015

    • Author(s)
      Kamoshita M, Matsumoto Y, Nishimura K, Katono Y, Murata M, Ozawa Y, Shimmura S, Tsubota K.
    • Journal Title

      Journal of Infection and Chemotherapy.

      Volume: 21 Issue: 2 Pages: 141-143

    • DOI

      10.1016/j.jiac.2014.08.019

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phase II enzyme induction by a carotenoid, lutein, in a PC12D neuronal cell line.2014

    • Author(s)
      Miyake S, Kobayashi S, Tsubota K, Ozawa Y
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 446 Issue: 2 Pages: 535-540

    • DOI

      10.1016/j.bbrc.2014.02.135

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Angiotensin II type 1 receptor blockade suppresses light-induced neural damage in the mouse retina.2014

    • Author(s)
      Narimatsu T, Ozawa Y, Miyake S, Nagai N, Tsubota K.
    • Journal Title

      Free Radical Biol Med

      Volume: 71 Pages: 176-185

    • DOI

      10.1016/j.freeradbiomed.2014.03.020

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ozawa Predictive factors for non-responders to intravitreal ranibizumab treatment in age-related macular degeneration2014

    • Author(s)
      Suzuki M, Nagai N, Izumi-Nagai K, Shinoda H, Koto T, Uchida A, Mochimaru H, Yuki K, Sasaki M, Tsubota K
    • Journal Title

      Br J Ophthalmol

      Volume: 98 Issue: 9 Pages: 7-7

    • DOI

      10.1136/bjophthalmol-2013-304670

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Maternal Age to Development and Progression of Retinopathy of Prematurity in Infants of Gestational Age under 33 Weeks.2014

    • Author(s)
      Uchida A, Miwa M, Shinoda H, Koto T, Nagai N, Mochimaru H, Tomita Y, Sasaki M, Ikeda K, Tsubota K, Ozawa Y
    • Journal Title

      J Ophthalmol.

      Volume: 2014 Pages: 187929-187929

    • DOI

      10.1155/2014/187929

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Early Signs of Exudative Age-related Macular Degeneration in Asians2014

    • Author(s)
      Sasaki M, Kawasaki R, Uchida A, Koto T, Shinoda H, Tsubota K, Tien Yin Wong, Ozawa Y
    • Journal Title

      Optometry and Vision Science.

      Volume: 91 Issue: 8 Pages: 849-853

    • DOI

      10.1097/opx.0000000000000317

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Resveratrol Prevents the Development of Choroidal Neovascularization by Modulating AMP-activated Protein Kinase in Macrophages and Other Cell Types.2014

    • Author(s)
      Nagai N, Kubota S, Tsubota K, Ozawa Y.
    • Journal Title

      J Nutr Biochem.

      Volume: 25 Issue: 11 Pages: 1218-1225

    • DOI

      10.1016/j.jnutbio.2014.05.015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa.2014

    • Author(s)
      Yoshida T, Ozawa Y, Suzuki K, Yuki K, Ohyama M, Akamatsu W, Matsuzaki Y, Shimmura S, Mitani K, Tsubota K, Okano H.
    • Journal Title

      Mol Brain.

      Volume: 7 Issue: 1 Pages: 45-45

    • DOI

      10.1186/1756-6606-7-45

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Decreased proteasomal activity causes photoreceptor degeneration in mice.2014

    • Author(s)
      Ando R, Noda K, Tomaru U, Kamoshita M, Ozawa Y, Notomi S, Hisatomi T, Noda M, Kanda A, Ishibashi T, Kasahara M, Ishida S.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 55 Issue: 7 Pages: 4682-4690

    • DOI

      10.1167/iovs.13-13272

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] AMPK-NF-κB Axis in the Photoreceptor Disorder during Retinal Inflammation.2014

    • Author(s)
      Kamoshita M, Ozawa Y, Kubota S, Miyake S, Tsuda C, Nagai N, Yuki K, Shimmura S, Umezawa K, Tsubota K.
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 7 Pages: 103013-103013

    • DOI

      10.1371/journal.pone.0103013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Intraoperative and fluorescein angiographic findings of a secondary macular hole associated with age-related macular degeneration treated by pars plana vitrectomy.2014

    • Author(s)
      Okamoto T, Shinoda H, Kurihara T, Nagai N Tsubota K, Ozawa Y.
    • Journal Title

      BMC Ophthalmology.

      Volume: 14 Issue: 1 Pages: 114-114

    • DOI

      10.1186/1471-2415-14-114

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Angiotensin II type 1 receptor blockade suppresses light-induced neural damage in the mouse retina.2014

    • Author(s)
      Narimatsu T, Ozawa Y, Miyake S, Nagai N, Tsubota K.
    • Journal Title

      Free Radical Biol Med.

      Volume: [Epub ahead of print] Pages: 1-10

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of Serum Lipids with Macular Thickness and Volume in Type 2 Diabetes without Diabetic Macular Edema.2014

    • Author(s)
      Sasaki M, Kawashima M, Kawasaki R, Uchida A, Koto T, Shinoda H, Tsubota K, Jie Jin Wang, Ozawa Y
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 55 Issue: 3 Pages: 1749-1753

    • DOI

      10.1167/iovs.13-13035

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Atp6ap2/(Pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice.2013

    • Author(s)
      Kanda A, Noda K, Yuki K, Ozawa Y, Furukawa T, Ichihara A & Ishida S
    • Journal Title

      J Neurosci.

      Volume: 33 Issue: 49 Pages: 19341-19351

    • DOI

      10.1523/jneurosci.1362-13.2013

    • NAID

      120005438252

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Biological effects of blocking blue and other visible light on the mouse retina.2013

    • Author(s)
      Narimatsu T, Ozawa Y, Miyake S, Kubota S, Yuki K, Nagai N, Tsubota K.
    • Journal Title

      Clinical & Experimental Ophthalmology.

      Volume: [Epub ahead of print] Issue: 6 Pages: 1-9

    • DOI

      10.1111/ceo.12253

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] ABCA4 Gene Screening by Next-Generation Sequencing in a British Cohort2013

    • Author(s)
      Fujinami K, Zernant J, Tsunoda K et al.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 54(10) Issue: 10 Pages: 6662-74

    • DOI

      10.1167/iovs.13-12570

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective Role of VEGF Induced in Response to Photodynamic Therapy.2013

    • Author(s)
      Ozawa Y, Suzuki M, Niikura N, Kamoshita M, Nagai N, Tsubota K
    • Journal Title

      Advances in Neuroimmune Biology

      Volume: 4 Issue: 3 Pages: 161-165

    • DOI

      10.3233/nib-130062

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Association between Visual Field Defect Severity and Fear of Falling in Primary Open-Angle Glaucoma.2013

    • Author(s)
      Yuki K, Tanabe S, Kouyama K, Fukagawa K, Uchino M, Shimoyama M, Ozeki N, Shiba D, Ozawa Y, Abe T, Tsubota K.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 54 Issue: 12 Pages: 7739-7745

    • DOI

      10.1167/iovs.13-12079

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type 1 receptor antagonist attenuates lacrimal gland, lung, and liver fibrosis in a murine model of chronic graft-versus-host disease.2013

    • Author(s)
      Yaguchi S, Ogawa Y, Shimmura S, Kawakita T, Hatou S, Satofuka S, Nakamura S, Imada T, Miyashita H, Yoshida S, Yaguchi T, Ozawa Y, Mori T, Okamoto S, Kawakami Y, Ishida S, Tsubota K.
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 6 Pages: e64724-e64724

    • DOI

      10.1371/journal.pone.0064724

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders.2013

    • Author(s)
      Kawashima M, Ozawa Y, Shinmura K, Inaba T, Nakamura S, Kawakita T, Watanabe M, Tsubota K.
    • Journal Title

      Exp Gerontol

      Volume: 48 Issue: 10 Pages: 1096-1100

    • DOI

      10.1016/j.exger.2013.04.002

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Blockade for Vascular Adsion Protein-1 Suppresses Pathological Neovascularization in Oxygen-Induced Retinopathy.2013

    • Author(s)
      Yoshikawa N, Noda K, Ozawa Y, Mashima Y, Ishida S.
    • Journal Title

      Acta Ophthalmologica.

      Volume: 91 Issue: 5

    • DOI

      10.1111/aos.12128

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Light-dark condition regulates sirtuin mRNA levels in the retina2013

    • Author(s)
      Ban N, Ozawa Y, Inaba T, Miyake S, Watanabe M, Shinmura K, Tsubota K.
    • Journal Title

      Exp Gerontol.

      Volume: 48 Issue: 11 Pages: 1212-1217

    • DOI

      10.1016/j.exger.2013.04.010

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Disruption of cell-cell junctions and induction of pathological cytokines in the retinal pigment epithelium of light-exposed mice.2013

    • Author(s)
      Narimatsu T, Ozawa Y, Miyake S, Kubota S, Hirasawa M, Nagai N, Shimmura S, Tsubota K.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 54 Issue: 7 Pages: 4555-4562

    • DOI

      10.1167/iovs.12-11572

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular Characteristics of Four Japanese Cases with KCNV2-retinopathy: Report of Novel Disease-causing Variants.2013

    • Author(s)
      Fujinami K, Tsunoda K, Nakamura N, Kato Y, Noda T, Shinoda K, Tomita K, Hatase T, Usui T, Akahori M, Itabashi T, Iwata T, Ozawa Y, Tsubota K, Miyake Y.
    • Journal Title

      Molecular Vision.

      Volume: 19 Pages: 1580-1590

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuroinflammation and Neurodegenerative Disorders of the Retina.2013

    • Author(s)
      Ozawa Y, Kamoshita M, Narimatsu T, Ban N, Toda E, Okamoto T, Yuki K, Miyake S Tsubota K
    • Journal Title

      Endocrinology & Metabolic Syndrome.

      Volume: 2 Issue: 01 Pages: 1-4

    • DOI

      10.4172/2161-1017.1000111

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vitrectomy for myopic foveoschisis with internal limiting membrane peeling and no gas tamponade.2013

    • Author(s)
      Uchida A, Shinoda H, Koto T, Mochimaru H, Nagai N, Tsubota K, Ozawa Y
    • Journal Title

      Retina.

      Volume: 34 Issue: 3 Pages: 455-460

    • DOI

      10.1097/iae.0b013e3182a0e477

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective Role of Superoxide Dismutase 1 in Retinal Ganglion Cells and Inner Nuclear layer Cells against N-methyl-D-aspartate -induced cytotoxicity2013

    • Author(s)
      Yuki K, Yoshida T, Miyake S, Tsubota K, Ozawa Y
    • Journal Title

      Exp. Eye Res

      Volume: 115 Pages: 230-238

    • DOI

      10.1016/j.exer.2013.07.002

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detection of Early Visual Impairment in Patients with Epiretinal Membrane.2013

    • Author(s)
      Nishi Y, Shinoda H, Uchida A, Koto T, Mochimaru H, Nagai N, Tsubota K, Ozawa Y.
    • Journal Title

      Acta Ophthalmologica

      Volume: Epub ahead of print Issue: 5 Pages: 1-5

    • DOI

      10.1111/aos.12060

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Renin-angiotensin system involvement in the oxidative stress-induced neurodegeneration of cultured retinal ganglion cells.2013

    • Author(s)
      Ozawa Y, Yuki K, Yamagishi R, Tsubota K, Aihara M.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 57 Issue: 1 Pages: 126-32

    • DOI

      10.1007/s10384-012-0204-x

    • NAID

      10031168368

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum vascular adhesion protein-1 correlates with vascular endothelial growth factor in patients with type II diabetes.2013

    • Author(s)
      Yoshikawa N, Noda K, Shinoda H, Uchida A, Ozawa Y, Tsubota K, Mashima Y, Ishida S.
    • Journal Title

      J Diabetes Complications.

      Volume: 27 Issue: 2 Pages: 162-6

    • DOI

      10.1016/j.jdiacomp.2012.09.001

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Presence and physiological function of Renin-Angiotensin System in mouse lacrimal gland.2012

    • Author(s)
      Yaguchi S, Ogawa Y, Shimmura S, Hatou S, Nakamura S, Inaba T, Imada T, Ozawa Y, Kawakami Y, Ishida S, Tsubota K.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 53 Issue: 9 Pages: 5416-25

    • DOI

      10.1167/iovs.12-9891

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Photo-damage mechanisms and anti-apoptotic effect of lutein in the mouse retina.2012

    • Author(s)
      Miyake S, Sasaki M, Takahashi N, Tsubota K, Ozawa Y.
    • Journal Title

      Inflammation and Regeneration.

      Volume: 32 Pages: 208-12

    • NAID

      130004482301

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Soluble Vascular Adhesion Protein-1 Accumulates in Proliferative Diabetic Retinopathy.2012

    • Author(s)
      Murata M, Noda K, Fukuhara J, Kanda A, Kase S, Saito W, Ozawa Y, Mochizuki S, Kimura S, Mashima Y, Okada Y, Ishida S.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 53 Issue: 7 Pages: 4055-62

    • DOI

      10.1167/iovs.12-9857

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Blockade of vascular adhesion protein-1 attenuates choroidal neovascularization.2012

    • Author(s)
      Yoshikawa N, Noda K, Ozawa Y, Tsubota K, Mashima Y, Ishida S.
    • Journal Title

      Mol Vis.

      Volume: 18 Pages: 593-600

    • NAID

      120005372295

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract : cellular and molecular mechanism2012

    • Author(s)
      Miyake S, Takahashi N, Sasaki M, Kobayashi S, Tsubota K, Ozawa Y
    • Journal Title

      Lab Invest

      Volume: 92(1) Issue: 1 Pages: 102-9

    • DOI

      10.1038/labinvest.2011.132

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Biological role of lutein in the light-induced retinal degeneration2012

    • Author(s)
      Sasaki M, Yuki K, Kurihara T, Miyake S, Noda K, Kobayashi S, Ishida S, Tsubota K, Ozawa Y.
    • Journal Title

      J Nutr Biochem

      Volume: 23 Issue: 5 Pages: 423-429

    • DOI

      10.1016/j.jnutbio.2011.01.006

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Usage of micronutrient supplement for preventing advanced Age-related Macular Degeneration in Japan2012

    • Author(s)
      Sasaki M, Shinoda H, Koto T, Uchida A, Tsubota K, Ozawa Y
    • Journal Title

      Archives of Ophthalmology

      Volume: 130(2) Issue: 2 Pages: 254-5

    • DOI

      10.1001/archopthalmol.2011.1368

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute visual field defect following vitrectomy determined to originate from optic nerve by electrophysiological tests.2012

    • Author(s)
      Uchida A, Shinoda K, Matsumoto C.S, Kawai M, Kawai S, Ohde H, Ozawa Y, Ishida S, Inoue M, Mizota A, Tsubota K.
    • Journal Title

      Case Rep Ophthalmol.

      Volume: 3 Issue: 3 Pages: 396-405

    • DOI

      10.1159/000345507

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective Effects of Lutein in the Retina2012

    • Author(s)
      Ozawa Y, Sasaki M, Takahashi N, Kamoshita M, Miyake S, Tsubota K
    • Journal Title

      Current Pharmaceutical Design

      Volume: 18(2) Issue: 1 Pages: 51-6

    • DOI

      10.2174/138161212798919101

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner2011

    • Author(s)
      Nakamura-Ishizu A, Kurihara T, Okuno Y, Ozawa Y, Kishi K, Goda N, Tsubota K, Okano H, Suda T, Kubota Y
    • Journal Title

      Dev Biol

      Volume: 363 Issue: 1 Pages: 106-114

    • DOI

      10.1016/j.ydbio.2011.12.027

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Management of AMD; anti-VEGF and anti-oxidant approaches.2014

    • Author(s)
      Ozawa Y
    • Organizer
      Autumn meeting of Taiwan Ophthalmology Academy
    • Place of Presentation
      Chiayi, Taiwan
    • Year and Date
      2014-10-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Anti-VEGF therapy in DME2014

    • Author(s)
      Ozawa Y
    • Organizer
      Autumn meeting of Taiwan Ophthalmology Academy
    • Place of Presentation
      Chiayi, Taiwan
    • Year and Date
      2014-10-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Oxidative stress in the retina and the pathogenesis2014

    • Author(s)
      Ozawa Y
    • Organizer
      Inflammatory mechanisms/oxidative stress
    • Place of Presentation
      ISOHK-APGC, Hong Kong,
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Circadian Regulation of Sirtuins in the Eye. Education Course.2014

    • Author(s)
      Ozawa Y
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Orland, FL, USA
    • Year and Date
      2014-05-04 – 2014-05-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Management of ME secondary to CRVO Macular edema secondary to Central Retinal Vein Occlusion. CRVO.2014

    • Author(s)
      Ozawa Y
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Orland, FL, USA
    • Year and Date
      2014-05-04 – 2014-05-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Renin-Angiotensin System (RAS) involvement in the Oxidative Stress-Induced Impairment of Retinal Neuronal Cells.2013

    • Author(s)
      Ozawa Y
    • Organizer
      3rd International Conference on Clinical & Experimental Ophthalmology,
    • Place of Presentation
      Chicago/Northbrook, USA
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Disruption of cell-cell junctions and induction of pathological cytokines in the retinal pigment epithelium of light-exposed mice.2013

    • Author(s)
      Ozawa Y,Narimatsu T, Kazuo T.
    • Organizer
      1st International Symposium of Blue Light Society
    • Place of Presentation
      JP TOWER Hall & Conference , Marunouchi, Chiyoda-ku, Tokyo
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Disruption of cell-cell junctions and induction of pathological cytokines in the retinal pigment epithelium of light-exposed mice.2013

    • Author(s)
      Ozawa Y
    • Organizer
      INTERNATIONAL RETINA SUMMIT
    • Place of Presentation
      Hong Kong
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Biological effects of blocking blue and over visible light on the mouse retina.2013

    • Author(s)
      Narimatsu T, Ozawa Y, Miyake S, Kubota S, Yuki K, Nagai N, Tsubota K.
    • Organizer
      1st International Symposium of Blue Light Society
    • Place of Presentation
      JP TOWER Hall & Conference , Marunouchi, Chiyoda-ku, Tokyo
    • Related Report
      2013 Research-status Report
  • [Presentation] Involvement of Angiopoietin-like 2 in Laser-induced Choroidal Neovascularization.2013

    • Author(s)
      Hirasawa M, Endo M, Kamoshita M, Miyake S, Narimatsu T, Nagai N, Tsubota K, Ozawa Y
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
    • Place of Presentation
      Washington State Convention & Trade Center Seattle
    • Related Report
      2013 Research-status Report
  • [Presentation] Associations of Serum Lipids with Macular Morphology in Patients without Diabetic Macular Edema.2013

    • Author(s)
      Sasaki M, Kawashima M, Kawasaki R, Kawai M, Uchida A, Koto T, Mochimaru H, Shinoda H, Jie Jin Wang, Tsubota K, Ozawa Y.
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
    • Place of Presentation
      Washington State Convention & Trade Center Seattle
    • Related Report
      2013 Research-status Report
  • [Presentation] Light-dark Condition Regulates Sirtuin Genes in the Retina.2013

    • Author(s)
      Ban N, Inaba T, Miyake S, Tsubota K, Ozawa Y.
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
    • Place of Presentation
      Washington State Convention & Trade Center Seattle
    • Related Report
      2013 Research-status Report
  • [Presentation] Baseline characteristics and response to intravitreal ranibizumab therapy for age-related macular degeneration.2013

    • Author(s)
      Suzuki M, Nagai N, Izumi-Nagai K, Shinoda H, Koto T, Uchida A, Mochimaru H, Yuki K, Tsubota K, Ozawa Y
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
    • Place of Presentation
      Washington State Convention & Trade Center Seattle
    • Related Report
      2013 Research-status Report
  • [Presentation] AMPK-NF-kB axis modulates visual function during inflammation.2013

    • Author(s)
      Kamoshita M, Kubota S, Yuki K, Miyake S, Nagai N, Umezawa K, Tsubota K, Ozawa Y.
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
    • Place of Presentation
      Washington State Convention & Trade Center Seattle
    • Related Report
      2013 Research-status Report
  • [Presentation] Disruption of cell-cell junctions and induction of pathological cytokines in the retinal pigment epithelium of light-exposed mice.2013

    • Author(s)
      Narimatsu T, Ozawa Y, Miyake S, Kubota S, Hirasawa M, Nagai N, Shimmura S, Tsubota K.
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
    • Place of Presentation
      Washington State Convention & Trade Center Seattle
    • Related Report
      2013 Research-status Report
  • [Presentation] Evaluation of functional visual acuity in advanced age-related macular degeneration with good visual acuity.2013

    • Author(s)
      Tomita Y, Nagai N, Suzuki M, Sasaki M, Tsubota K, Ozawa Y
    • Organizer
      Asia Pacific Vitreo-retina Society Congress
    • Place of Presentation
      名古屋国際会議場 (愛知県名古屋市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 脈絡膜新生血管モデルにおける Angiopoietin-like 2の関与2013

    • Author(s)
      平沢学, 遠藤元誉, 鴨下衛, 成松俊雄, 三宅誠司, 永井紀博, 坪田一男, 尾池雄一, 小沢洋子
    • Organizer
      第117回 日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム (東京都千代田区)
    • Related Report
      2013 Research-status Report
  • [Presentation] AMP活性化プロテインキナーゼによる抗炎症作用と視機能維持2013

    • Author(s)
      鴨下衛, 久保田俊介, 三宅誠司, 結城賢弥, 永井紀博, 梅澤一夫, 坪田一男, 小沢洋子.
    • Organizer
      第117回 日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム (東京都千代田区)
    • Related Report
      2013 Research-status Report
  • [Presentation] AMP活性化プロテインキナーゼ経路を介した実験的脈絡膜新生血管の抑制2013

    • Author(s)
      永井紀博,久保田俊介,坪田一男,小澤洋子
    • Organizer
      第117回 日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム (東京都千代田区)
    • Related Report
      2013 Research-status Report
  • [Presentation] 狭義加齢黄斑変性に対するpro re nateによるラニビズマブ硝子体注射.2013

    • Author(s)
      鈴木美砂, 永井紀博, 永井香奈子, 篠田肇, 内田敦郎, 厚東隆志, 持丸博史, 富田洋平, 佐々木真理子, 坪田一男, 小沢洋子.
    • Organizer
      第67回日本臨床眼科学会
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 抗VEGF療法に反応不良の滲出型加齢黄斑変性に対するアフリベルセプトの作用.2013

    • Author(s)
      永井紀博,永井香奈子,鈴木美砂,持丸博史,富田洋平,内田敦郎,佐々木真理子,篠田肇,坪田一男,小沢洋子
    • Organizer
      第67回日本臨床眼科学会
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Related Report
      2013 Research-status Report
  • [Presentation] iPS細胞を用いた網膜色素変性症における視細胞の変性機構の解析2013

    • Author(s)
      吉田哲、小沢洋子、鈴木啓一郎、平林由香、鈴木禎史、小泉春菜、結城賢弥、小林哲郎、大山学、天谷雅行、岡田洋平、赤松和土、松崎有未、三谷幸之介、榛村重人、坪田一男、岡野栄之
    • Organizer
      第12回  日本再生医療学会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2012 Research-status Report
  • [Presentation] An analysis of the mechanisms of degradation of photoreceptor cells in a retinitis pigmentosa patient using iPS cells.2012

    • Author(s)
      Yoshida T, Ozawa Y, Hirabayashi Y, Suzuki K, Mitani K, Kobayashi T, Ohyama M, Amagai M, Okada Y, Akamatsu W, Tsubota K, Shimmura S, Okano H.
    • Organizer
      International Society for Stem Cell Research (ISSCR) 10th annual meeting,
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2012 Research-status Report
  • [Presentation] An analysis of the mechanisms of degradation of photoreceptor cells in a retinitis pigmentosa patient using iPS cells.2012

    • Author(s)
      Yoshida T, Ozawa Y, Suzuki K, Hirabayashi Y, Suzuki S, Koizumi H, Yuki K, Kobayashi T, Ohyama M, Amagai M, Okada Y, Akamatsu W, Matsuzaki Y, Mitani K, Shimmra S, Tsubota K, Okano H.
    • Organizer
      Global COE Final Symposium .Center for Integrated Medical Research,
    • Place of Presentation
      東京都新宿区
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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