Pathophysiological Analysis of Atopic Glaucoma

• Project/Area Number: 24592652
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Juntendo University
• Principal Investigator: MATSUDA Akira 順天堂大学, 医学(系)研究科(研究院), 准教授 (00312348)
• Co-Investigator(Kenkyū-buntansha): ONO Kouichi 順天堂大学, 医学部, 准教授 (10317399) ; MORI Kazuhiko 京都府立医科大学, 大学院医学研究科, 講師 (40252001)
• Co-Investigator(Renkei-kenkyūsha): NAKAE Susumu 東京大学, 医科学研究所, 准教授 (60450409)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: アトピー / 緑内障 / ステロイド / 組織瘢痕化 / アトピー性皮膚炎

Outline of Final Research Achievements

Open-angle glaucoma associated with severe atopic dermatitis (atopic glaucoma) tends to be severe and difficult to treat because of ocular surface/eye lid inflammation. Atopic glaucoma was often associated with atopic cataracts and retinal detachments. Surgical interventions are common because of advanced visual field defects and/or high intraocular pressures. Bleb-associated post-surgical infections were observed in 7 eyes. Ultrastructural analysis of trabecular meshwork tissues obtained from atopic
glaucoma patients showed abnormal accumulation of 10 to 30nm fibers in the corneoscleral meshwork.

Research Products

• [Journal Article] Atopic Glaucoma: Clinical and Pathophysiological Analysis (2015)
  • Author(s): Takakuwa K, Hamanaka T, Mori K, Chin S, Shinmei Y, Funaki T, Ebihara N, Ono K, Murakami A, Matsuda A.
  • Journal Title: J Glaucoma Volume: in press Issue: 9 Pages: 662-668
  • DOI: 10.1097/ijg.0000000000000069
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] DNA methylation analysis of human trabecular meshwork cells during dexamethasone stimulation (2015)
  • Author(s): Akira Matsuda, Yosuke Asada, Kanae Takakuwa, Jobu Sugita, Akira Murakami, Nobuyuki Ebihara
  • Journal Title: Invest Ophthalmol Vis Sci Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Vernal keratoconjunctivitis with giant papillae on the inferior tarsal conjunctiva. (2014)
  • Author(s): Asada Y, Ebihara N, Funaki T, Yokoi N, Murakami A, Matsuda A.
  • Journal Title: Cornea Volume: 33 Issue: 1 Pages: 32-34
  • DOI: 10.1097/ico.0000000000000009
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Atopic glaucoma―clinical and pathophysiological analysis. (2014)
  • Author(s): Takakuwa K, Hamanaka T, Mori K, Chin S, Shinmei Y, Funaki T, Ebihara N, Ono K, Murakami A, Matsuda A.
  • Journal Title: J Glaucoma Volume: in press
  • Peer Reviewed
• [Journal Article] IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation. (2013)
  • Author(s): Kamijo S, Takeda H, Tokura T, Suzuki1 M, Inui K, Hara M, Matsuda H, Matsuda A, Oboki K, Ohno T, Saito H, Nakae S, Sudo K, Suto H, Ichikawa S, Ogawa H, Okumura K, and Takai T
  • Journal Title: J Immunol Volume: In press
  • Peer Reviewed
• [Journal Article] Filaggrin mutations are not associated with chronic allergic keratoconjunctivitis. (2012)
  • Author(s): Iwamoto S, Ebihara N, Hori K, Funaki T, Asada Y, Yokoi N, Inatomi T, Kawasaki S, Murakami A, Matsuda A.
  • Journal Title: Br J Ophthalmol. Volume: 96 Pages: 1272-1273
  • Peer Reviewed
• [Presentation] 当院におけるBaerbeldt緑内障インプラント手術、術後６ヶ月成績 (2015)
  • Author(s): 本田理峰 大山祐佳里 春日俊光 松田彰 村上晶
  • Organizer: 第３８回日本眼科手術学会
  • Place of Presentation: 京都
  • Year and Date: 2015-01-30 – 2015-02-01
• [Presentation] Cornea and glaucoma surgery (2014)
  • Author(s): Akira Matsuda
  • Organizer: 7th International congress of Glaucoma Surgery
  • Place of Presentation: シンガポール
  • Invited
• [Presentation] Double ligation technique for GDI with corneal patch (2012)
  • Author(s): Akira Matsuda
  • Organizer: Refractory glaucoma conference
  • Place of Presentation: Gainesville, FL, USA
  • Invited