Investigation of pathogenesis and novel treatment for intraocular lymphoma
| Project/Area Number |
24592655
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Tokyo Medical University |
|---|
Principal Investigator |
GOTO Hiroshi 東京医科大学, 医学部, 教授 (10201500)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
USUI Yoshihiko 東京医科大学, 医学部, 講師 (50408142)
YAMAKAWA Naoyuki 東京医科大学, 医学部, 助教 (80599134)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 眼内悪性腫瘍 / 眼内リンパ腫 / ぶどう膜炎 / サイトカイン / ケモカイン / BCA-1 / IL-10 |
|---|
| Outline of Final Research Achievements |
Five year survival rate of primary intraocular lymphoma (PIOL) is approximately 60 %, because most the patients develop central nervous system lymphoma.
In this study, we detected new diagnostic marker including BCA-1 by analyzing multiple humoral factors in the vitreous of patients with PIOL. We also identified recurrent copy number gain regions in PIOL, most frequently on chromosome 1q. In addition, there was a correlation between gain of the IL-10 gene and intravitreal interleukin-10 concentration. We have reported that life prognosis of the patients with higher concentration of IL-10 in the vitreous is worse compared to those with lower. These data may contribute to understand pathogenesis of PIOL and develop a novel treatment for patients with PIOL.
|
Report
(4 results)
Research Products
(11 results)
-
-
[Journal Article] High-resolution genomic copy number profiling of primary intraocular lymphoma by single nucleotide polymorphism microarrays.2014
Author(s)
Wang L, Sato-Otsubo A, Sugita S, Takase H, Mochizuki M,Usui Y, Goto H, Koyama T , Akiyama H, Miura O, Ogawa S, Arai A.
-
Journal Title
Cancer Science
Volume: 未定
Issue: 5
Pages: 592-599
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Immune mediators in vitreous fluids from patients with vitreoretinal B cell lymphoma.2012
Author(s)
Usui Y, Wakabayashi Y, Okunuki Y, Kimura K, Tajima K, Matsuda R, Ueda S, Ma J, Nagai T, Mori H, Kezuka T, Nagao T, Goto H.
-
Journal Title
Invest Ophthalmol Vis Sci
Volume: 53
Issue: 9
Pages: 5395-402
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
