Rapid and accurate surveillance of adenoviral conjunctivitis
Project/Area Number |
24592662
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
FUJIMOTO Tsuguto 国立感染症研究所, その他部局等, その他 (60446771)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | サーベイランス / 検査 / 公衆衛生 / アデノウイルス / 組換え型 / 早期探知 / 組換え型ウイルス / 眼科 / 小児科 / 新型アデノウイルス / 国際研究者交流 マレーシア / 制限酵素切断解析 / 分子疫学 / 学校サーベイランス / 結膜炎 |
Outline of Final Research Achievements |
Since 2007, new genotypes of HAdVs had been reported and caused outbreaks in Japan. New genotypes were mainly designed by complete genome sequence (or plural important region). In this study we used syndromic surveillances of to detect outbreaks of HAdVs, rapidly. By using plural PCR applications, rapid typing was possible from 90 ocular samples and 300 respiratory samples. As the result, respiratory HAdVs were typed as HAdV-1 to -5, HAdV-56, and HAdV-57. Ocular HAdVs were typed as HAdV-1 to -5, HAdV-8, HAdV-11, HAdV-37, HAdV-53, HAdV-54, HAdV-56, HAdV-64, and HAdV-48 related recombinant strain. Novel HAdV-48 related recombinant strain isolated in two area. HAdV-3 was most frequently associated with outbreaks of pharyngoconjunctival fever. HAdV-4 caused respiratory infections among children.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] A Case of Atypical Hand-Foot-and-Mouth Disease Caused by Coxsackievirus A6: Differential Diagnosis from Varicella in a Pediatric Intensive Care Unit.2013
Author(s)
Yasui Y, Makino T, Hanaoka N, Owa K, Horikoshi A, Tanaka A, Suehiro Y, Shimizu H, Kanou K, Kobayashi M, Konagaya M, Fujimoto T.
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Journal Title
Jpn J Infect Dis.
Volume: 66(6)
Pages: 564-566
NAID
Related Report
Peer Reviewed
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[Journal Article] Clinical manifestations of coxsackievirus A6 infection associated with a major outbreak of hand, foot, and mouth disease in Japan.2013
Author(s)
Kobayashi M, Makino T, Hanaoka N, Shimizu H, Enomoto M, Okabe N, Kanou K, Konagaya M, Oishi K, Fujimoto T.
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Journal Title
Jpn J Infect Dis.
Volume: 66(3)
Pages: 260-261
NAID
Related Report
Peer Reviewed
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[Journal Article] Isolation of an intertypic recombinant human adenovirus (candidate type 56) from the pharyngeal swab of a patient with pharyngoconjunctival fever.2012
Author(s)
Enomoto M, Okafuji T, Okafuji T, Chikahira M, Konagaya M, Hanaoka N, Adhikary AK, Takai D, Sugawara T, Hayashi Y, Oishi K, Fujimoto T.
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Journal Title
Japanese Journal of Infectious Diseases
Volume: 65(5)
Pages: 457-459
NAID
Related Report
Peer Reviewed
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[Journal Article] Novel human adenovirus strains2012
Author(s)
Matsushima Y, Shimizu H, Kano A, Nakajima E, Ishimaru Y, Dey SK, Watanabe Y, Adachi F, Suzuki K, Mitani K, Fujimoto T, Phan TG, Ushijima H
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Journal Title
Bangladesh. Emerg Infect Dis
Volume: (in press)
Issue: 5
Pages: 846-848
DOI
Related Report
Peer Reviewed
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[Journal Article] Incidence and treatment strategy for disseminated adenovirus disease after haploidentical stem cell transplantation.2012
Author(s)
Taniguchi K, Yoshihara S, Tamaki H, Fujimoto T, Ikegame K, Kaida K, Nakata J, Inoue T, Kato R, Fujioka T, Okada M, Soma T, Ogawa H.
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Journal Title
Annals of Hematology
Volume: 91(8)
Issue: 8
Pages: 1305-1312
DOI
Related Report
Peer Reviewed
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[Book] 保育界2013
Author(s)
藤本嗣人、菅原民枝、小長谷昌未、花岡希、大日康史
Total Pages
6
Publisher
日本保育協会
Related Report
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