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A basic research for the development of corneal surgeries that considered the quality of vision and corneal biomechanics

Research Project

Project/Area Number 24592669
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionOsaka University

Principal Investigator

MAEDA Naoyuki  大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (00273623)

Co-Investigator(Kenkyū-buntansha) TSUJIKAWA Motokazu  大阪大学, 大学院医学系研究科, 寄附講座教授 (70419472)
KOH Shizuka  大阪大学, 大学院医学系研究科, 助教 (00570590)
SOMA Takeshi  大阪大学, 大学院医学系研究科, 特任助教(常勤) (70582401)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords視覚の質 / 生体力学 / 角膜形状 / 波面収差 / 手術 / 視機能 / 生体力学的特性 / 角膜 / 治療 / 円錐角膜
Outline of Final Research Achievements

To develop new corneal surgeries with good quality of vision, we created the methodology for evaluating higher-order aberrations due to donor and host cornea following keratoplasty. For the early detection of contraindication of LASIK, the characteristics of corneal topography in keratoconus and its related diseases were determined. In addition, the importance of the treatment of dry eye after corneal surgeries was suggested from the loss of visual function in dry eye patients with normal corneal shape. Also, corneal biomechanical analysis indicated the rigidity of the cornea following current keratoplasties were weaker than that in normal eye.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2014 2013 2012

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Acknowledgement Compliant: 5 results,  Open Access: 1 results)

  • [Journal Article] Efficacy of spherical aberration correction based on contact lens power.2014

    • Author(s)
      Shizuka Koh, Naoyuki Maeda, Tsunekazu Hamada, Kohji Nishida
    • Journal Title

      Cont Lens Anterior Eye

      Volume: 37 Issue: 4 Pages: 2014-2014

    • DOI

      10.1016/j.clae.2013.12.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher-order aberrations of anterior and posterior corneal surfaces in patients with keratectasia after LASIK.2014

    • Author(s)
      Naoyuki Maeda, Tomoya Nakagawa, Ryo Kosaki, Shizuka Koh, Makoto Saika, Takasih Fujikado, Kohji Nishida
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 55 Issue: 6 Pages: 3905-3911

    • DOI

      10.1167/iovs.14-14391

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Evaluation of corneal epithelial and stromal thickness in keratoconus using spectral-domain optical coherence tomography.2014

    • Author(s)
      Naoyuki Maeda, Tomoya Nakagawa, Ritsuko Higashiura, Mutsumi Fuchihata, Shizuka Koh, Kohji Nishida
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 58 Issue: 5 Pages: 389-395

    • DOI

      10.1007/s10384-014-0338-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Corneal biomechanical properties in 3 corneal transplantation techniques with a dynamic Scheimpflug analyzer.2014

    • Author(s)
      Naoyuki Maeda, Ryotaro Ueki, Mutsumi Fuchihata, Hisataka Fujimoto, Shizuka Koh, Kohji Nishida
    • Journal Title

      Jpn J Ophthalmol

      Volume: 58 Issue: 6 Pages: 483-489

    • DOI

      10.1007/s10384-014-0344-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ocular forward light scattering and corneal backward light scattering in patients with dry eye2014

    • Author(s)
      Shizuka Koh, Naoyuki Maeda, Chikako Ikeda, Sanae Asonuma, Hayato Mitamura, Yoshinori Oie, Takesh Soma, Motokazu Tsujikawa, Satoshi Kawasaki, Kohji Nishida
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 55 Issue: 10 Pages: 6601-6606

    • DOI

      10.1167/iovs.14-15125

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Corneal topographic analysis of patients with Mooren’s ulcer using 3-dimensional anterior segment optical coherence tomography.2014

    • Author(s)
      Masahito Yoshihara, Naoyuki Maeda, Takeshi Soma, Mutsumi Fuchihata, Asumi Hayashi, Shizuka Koh, Yoshinori Oie, Kohji Nishida
    • Journal Title

      Cornea

      Volume: 34 Issue: 1 Pages: 54-59

    • DOI

      10.1097/ico.0000000000000237

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Characteristics of corneal topographic and pachymetric patterns in patients with pellucid marginal corneal degeneration2014

    • Author(s)
      Fuchihata M, Maeda N, Toda R, Koh S, Fujikado T, Nishida K
    • Journal Title

      Jpn J Ophthalmol

      Volume: 58-2 Issue: 2 Pages: 131-138

    • DOI

      10.1007/s10384-013-0291-3

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of Rebamipide Ophthalmic Suspension on Optical Quality in the Short Break-up Time Type of Dry Eye2013

    • Author(s)
      146) Shizuka Koh, Yasushi Inoue, Toshiki Sugmimoto, Naoyuki Maeda, Kohji Nishida
    • Journal Title

      Cornea

      Volume: 32 Issue: 9 Pages: 1219-1223

    • DOI

      10.1097/ico.0b013e318294f97e

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of Instillation of Dry Eye Drops on Optical Quality.2013

    • Author(s)
      Koh S, Maeda N, Ikeda C, Takai Y, Fujimoto H, Oie Y, Soma T, Tsujikawa M, Nishida K.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: Epub Issue: 7 Pages: 4927-4933

    • DOI

      10.1167/iovs.13-12409

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Four discriminant models for detecting keratoconus pattern using Zernike coefficients of corneal aberrations2013

    • Author(s)
      Saika M, Maeda N, Hirohara Y, Mihashi T, Fujikado T, Nishida K
    • Journal Title

      Jpn J Ophthalmol

      Volume: 57 Issue: 6 Pages: 503

    • DOI

      10.1007/s10384-013-0269-1

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Corneal Topographic analysis by 3-dimensional anterior segment optical coherence tomography after endothelial keratoplasty.2012

    • Author(s)
      Higashiura R, Maeda N, Nakagawa T, Fuchihata M, Koh S, Hori Y, Inoue T, Nishida K
    • Journal Title

      Investigative ophthalmology & visual science

      Volume: 53(7) Issue: 7 Pages: 3286-3295

    • DOI

      10.1167/iovs.12-9602

    • Related Report
      2012 Research-status Report
    • Peer Reviewed

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Published: 2013-05-31   Modified: 2019-07-29  

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