Development of a new surgical viewing system and investigation of new efficacy based on a new surgical adjuvant we have already developed.
| Project/Area Number |
24592673
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Saga University (2013-2014)
Kyushu University (2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIBASHI Tatsuro 九州大学病院, 病院長 (30150428)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ブリリアントブルーG(BBG) / 神経保護作用 / P2X7アンタゴニスト / 手術用観察系 / マイクロ鑷子 / 硝子体手術 / 医師主導治験 / 補助剤 / ブリリアントブルーG / 医療器機開発 / 神経保護効果 / 薬理作用 / 開発研究 / 観察系 / 神経保護 / 抗炎症 / 安全性 |
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| Outline of Final Research Achievements |
It is important to secure visibility during microsurgery. In vitreous surgery, staining and peeling of the internal limiting membrane (ILM) with vital dyes have been widely performed. Recently we have developed Brilliant Blue G (BBG) as a new safety adjuvant for vitreous surgery. BBG was already approved and marketed in Europe Union. In this study, we found that BBG has a neuroprotective advantages. Our data showed that ATP and P2X7 receptor may induce retinal damage in experimental models, which is effectively inhibit by BBG.In this time, we have developed a new surgical viewing system was as a clinical prototype. This system improved intraoperative visibility under air infusion and the BBG staining intensity by sharp cut filter during vitrectomy.
Moreover, we developed a new and economical disposable micro forceps for a microincision vitrectomy surgery that has high performance and versatility from BBG stained ILM during surgery.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Ultrastructural Changes of the Vitreoretinal Interface During Long-Term Follow-up After Removal of the Internal Limiting Membrane.2014
Author(s)
Hisatomi T, Notomi S, Tachibana T, Sassa Y, Ikeda Y, Nakamura T, Ueno A, Enaida H, Murata T, Sakamoto T, Ishibashi T
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Journal Title
Am J Ophthalmol
Volume: 158
Issue: 3
Pages: 550-556
DOI
Related Report
Peer Reviewed
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[Journal Article] Dynamic increase in extracellular ATP accelerates photoreceptor cell apoptosis via ligation of P2RX7 in subretinal hemorrhage2013
Author(s)
Notomi S, Hisatomi T, Murakami Y, Terasaki H, Sonoda S, Asato R, Takeda A, Ikeda Y, Enaida H, Sakamoto T, Ishibashi T
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Journal Title
PLoS One
Volume: epub ahead
Issue: 1
Pages: e53338-e53338
DOI
Related Report
Peer Reviewed
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